Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: LEWQLQACE DQQCCPEMGG WSGWGPWEPC SVTCSKGTRT RRRACNHPAP KCGGHCPGQA QESEACDTQQ VCPTHGAWAT WGPWTPCSAS CHGGPHEPKE TRSRKCSAPE PSQKPPGKPC PGLAYEQRRC TGLPPCPVAG GWGPWGPVSP CPVTCGLGQT MEQRTCNHPV PQHGGPFCAG DATRTHICNT AVPCPVDGEW DSWGEWSPCI RRNMKSISCQ EIPGQQSRGR TCRGRKFDGH RCAGQQQDIR HCYSIQHCPL KGSWSEWSTW GLCMPPCGPN PTRARQRLCT PLLPKYPPTV SMVEGQGEKN VTFWGRPLPR CEELQGQKLV VEEKRPCLHV PACKDPEEEE L (120-469 aa encoded by BC015756)
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bf; C3 Proaccelerator; cfb; Complement factor P; H2-Bf; Properdin; properdin factor, complement; Properdin P factor, complement
Gene Aliases: BFD; CFP; PFC; PFD; PROPERDIN
UniProt ID: (Human) P27918
Entrez Gene ID: (Pig) 100522293, (Human) 5199, (Rat) 299314
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