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CGRP Antibody (OSC00190W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse spinal cord. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 200 mL 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chrom... View More
Product Details
OSC00190W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse CGRP conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: CGRP.
Target Information
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-type CGRP; Calcitonin; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; MGC126648; RAT calcitonin
Gene Aliases: CA; Cal1; CAL6; Calc; Calc1; Calca; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6
UniProt ID: (Rat) P01257, (Mouse) P70160
Entrez Gene ID: (Rat) 24241, (Mouse) 12310
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
G-protein coupled receptor internalization
monocyte chemotaxis
protein phosphorylation
cellular calcium ion homeostasis
inflammatory response
leukocyte cell-cell adhesion
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
neuromuscular junction development
embryo implantation
aging
feeding behavior
regulation of heart contraction
regulation of blood pressure
response to heat
negative regulation of calcium ion transport into cytosol
negative regulation of ossification
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of neurological system process
activation of protein kinase activity
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
positive regulation of adenylate cyclase activity
negative regulation of blood pressure
positive regulation of ossification
negative regulation of bone resorption
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of smooth muscle contraction
response to pain
detection of temperature stimulus involved in sensory perception of pain
regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cellular response to tumor necrosis factor
cellular response to nerve growth factor stimulus
sperm capacitation
mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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