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Product Details
OSC00061W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the n-terminal of human CHMP4B, C conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in many other species including rat, mouse, zebrafish and xenopus.
Specificity of this antibody: CHMP4B, C.
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP4b; CHMP4c; chromatin modifying protein 4B; chromatin modifying protein 4C; Chromatin-modifying protein 4b; Chromatin-modifying protein 4c; hSnf7-2; hSnf7-3; hVps32-2; hVps32-3; SNF7 homolog associated with Alix 1; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 1; Snf7 homologue associated with Alix 3; SNF7-2; SNF7-3; Vacuolar protein sorting-associated protein 32-2; Vacuolar protein sorting-associated protein 32-3; vacuolar protein-sorting-associated protein 32-2; Vps32-2; Vps32-3
Gene Aliases: 2010012F05Rik; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; C20orf178; C76846; CHMP4A; CHMP4B; CHMP4C; CTPP3; CTRCT31; dJ553F4.4; RGD1309846; RGD1565889; SHAX1; SHAX3; SNF7; SNF7-2; SNF7-3; Vps32-2; VPS32B; VPS32C
UniProt ID: (Human) Q9H444, (Human) Q96CF2, (Mouse) Q9D8B3, (Mouse) Q9D7F7, (Rat) Q569C1
Entrez Gene ID: (Human) 128866, (Human) 92421, (Mouse) 75608, (Rat) 100359642, (Mouse) 66371, (Rat) 361916
mitotic cytokinesis
cell separation after cytokinesis
posttranslational protein targeting to membrane
autophagy
nucleus organization
mitotic metaphase plate congression
exit from mitosis
regulation of centrosome duplication
endosomal transport
viral life cycle
nuclear envelope reassembly
multivesicular body assembly
maintenance of lens transparency
viral budding via host ESCRT complex
viral budding
regulation of viral process
protein homooligomerization
negative regulation of cell death
membrane fission
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
cell-cell adhesion
negative regulation of neuron death
regulation of mitotic spindle assembly
positive regulation of viral release from host cell
negative regulation of autophagosome assembly
abscission
protein transport
negative regulation of cytokinesis
transport
vacuolar transport
bioluminescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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