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CHRM2 Antibody (MA5-52936) in WB
Western Blot analysis of CHRM2. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CHRM2 recombinant monoclonal antibody (Product # MA5-52936) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Product Details
MA5-52936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5875
Immunogen
A synthesized peptide derived from human ACM2 (152-180AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2 muscarinic acetylcholine receptor; M2-mAChR; m2AChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor; muscarinic receptor m2
Gene Aliases: AChR-M2; Acm2; Chrm-2; CHRM2; HM2; M2
UniProt ID: (Human) P08172, (Mouse) Q9ERZ4, (Rat) P10980
Entrez Gene ID: (Human) 1129, (Mouse) 243764, (Rat) 81645
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
regulation of heart contraction
response to virus
signal transduction
chemical synaptic transmission
sensory perception of chemical stimulus
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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