Product References
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
bioRxiv : the preprint server for biology
Dreishpoon MB,Bick NR,Petrova B,Warui DM,Cameron A,Booker SJ,Kanarek N,Golub TR,Tsvetkov P
Sat Feb 04 00:00:00 EST 2023
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.
The Journal of biological chemistry
Hayashida R,Kikuchi R,Imai K,Kojima W,Yamada T,Iijima M,Sesaki H,Tanaka K,Matsuda N,Yamano K
Wed Feb 01 00:00:00 EST 2023
Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress.
Cell death & disease
Lee S,Seok BG,Lee SJ,Chung SW
Tue Feb 08 00:00:00 EST 2022
PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity.
Journal of biomedical science
Chen JY,Wu YP,Li CY,Jheng HF,Kao LZ,Yang CC,Leu SY,Lien IC,Weng WT,Tai HC,Chiou YW,Tang MJ,Tsai PJ,Tsai YS
Mon Mar 29 00:00:00 EDT 2021
Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy.
International journal of biological sciences
Li L,Yu S,Hu Q,Hai Y,Li Y
Fri Mar 18 00:00:00 EDT 2022
Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy.
International journal of biological sciences
Li L,Yu S,Hu Q,Hai Y,Li Y
Fri Mar 18 00:00:00 EDT 2022
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Science advances
Antico O,Ordureau A,Stevens M,Singh F,Nirujogi RS,Gierlinski M,Barini E,Rickwood ML,Prescott A,Toth R,Ganley IG,Harper JW,Muqit MMK
Fri Nov 12 00:00:00 EST 2021
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy.
Science advances
Hung CM,Lombardo PS,Malik N,Brun SN,Hellberg K,Van Nostrand JL,Garcia D,Baumgart J,Diffenderfer K,Asara JM,Shaw RJ
Thu Apr 01 00:00:00 EDT 2021
Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.
Molecular cell
Ordureau A,Paulo JA,Zhang J,An H,Swatek KN,Cannon JR,Wan Q,Komander D,Harper JW
Thu Mar 05 00:00:00 EST 2020
Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma.
Biochimica et biophysica acta. Molecular basis of disease
Roche ME,Lin Z,Whitaker-Menezes D,Zhan T,Szuhai K,Bovee JVMG,Abraham JA,Jiang W,Martinez-Outschoorn U,Basu-Mallick A
Tue Dec 01 00:00:00 EST 2020
Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury.
Experimental neurology
Yonutas HM,Hubbard WB,Pandya JD,Vekaria HJ,Geldenhuys WJ,Sullivan PG
Fri May 01 00:00:00 EDT 2020
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Communications biology
Watanabe M,Saeki Y,Takahashi H,Ohtake F,Yoshida Y,Kasuga Y,Kondo T,Yaguchi H,Suzuki M,Ishida H,Tanaka K,Hatakeyama S
Tue Oct 20 00:00:00 EDT 2020
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics.
EMBO reports
Molino D,Pila-Castellanos I,Marjault HB,Dias Amoedo N,Kopp K,Rochin L,Karmi O,Sohn YS,Lines L,Hamaï A,Joly S,Radreau P,Vonderscher J,Codogno P,Giordano F,Machin P,Rossignol R,Meldrum E,Arnoult D,Ruggieri A,Nechushtai R,de Chassey B,Morel E
Thu Dec 03 00:00:00 EST 2020
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
The Journal of biological chemistry
Koyano F,Yamano K,Kosako H,Tanaka K,Matsuda N
Fri Jun 28 00:00:00 EDT 2019
Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.
Science advances
Heo JM,Harper NJ,Paulo JA,Li M,Xu Q,Coughlin M,Elledge SJ,Harper JW
Fri Nov 01 00:00:00 EDT 2019
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand.
Communications chemistry
Geldenhuys WJ,Long TE,Saralkar P,Iwasaki T,Nuñez RAA,Nair RR,Konkle ME,Menze MA,Pinti MV,Hollander JM,Hazlehurst LA,Robart AR
Wed Feb 23 00:00:00 EST 2022
Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
EMBO reports
Koyano F,Yamano K,Kosako H,Kimura Y,Kimura M,Fujiki Y,Tanaka K,Matsuda N
Thu Dec 05 00:00:00 EST 2019
Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development.
Developmental neurobiology
Stauch KL,Villeneuve LM,Totusek S,Lamberty B,Ciborowski P,Fox HS
Mon Apr 01 00:00:00 EDT 2019
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
Cell metabolism
McWilliams TG,Prescott AR,Montava-Garriga L,Ball G,Singh F,Barini E,Muqit MMK,Brooks SP,Ganley IG
Tue Feb 06 00:00:00 EST 2018
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
Cell metabolism
McWilliams TG,Prescott AR,Montava-Garriga L,Ball G,Singh F,Barini E,Muqit MMK,Brooks SP,Ganley IG
Tue Feb 06 00:00:00 EST 2018
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
Molecular cell
Ordureau A,Paulo JA,Zhang W,Ahfeldt T,Zhang J,Cohn EF,Hou Z,Heo JM,Rubin LL,Sidhu SS,Gygi SP,Harper JW
Thu Apr 19 00:00:00 EDT 2018
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
Molecular cell
Ordureau A,Paulo JA,Zhang W,Ahfeldt T,Zhang J,Cohn EF,Hou Z,Heo JM,Rubin LL,Sidhu SS,Gygi SP,Harper JW
Thu Apr 19 00:00:00 EDT 2018
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.
Anticancer research
Meram AT,Chen J,Patel S,Kim DD,Shirley B,Covello P,Coppola D,Wei EX,Ghali G,Kevil CG,Shackelford RE
Sun Jul 01 00:00:00 EDT 2018
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.
Anticancer research
Meram AT,Chen J,Patel S,Kim DD,Shirley B,Covello P,Coppola D,Wei EX,Ghali G,Kevil CG,Shackelford RE
Sun Jul 01 00:00:00 EDT 2018
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Open biology
McWilliams TG,Barini E,Pohjolan-Pirhonen R,Brooks SP,Singh F,Burel S,Balk K,Kumar A,Montava-Garriga L,Prescott AR,Hassoun SM,Mouton-Liger F,Ball G,Hills R,Knebel A,Ulusoy A,Di Monte DA,Tamjar J,Antico O,Fears K,Smith L,Brambilla R,Palin E,Valori M,Eerola-Rautio J,Tienari P,Corti O,Dunnett SB,Ganley IG,Suomalainen A,Muqit MMK
Wed Nov 07 00:00:00 EST 2018
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Open biology
McWilliams TG,Barini E,Pohjolan-Pirhonen R,Brooks SP,Singh F,Burel S,Balk K,Kumar A,Montava-Garriga L,Prescott AR,Hassoun SM,Mouton-Liger F,Ball G,Hills R,Knebel A,Ulusoy A,Di Monte DA,Tamjar J,Antico O,Fears K,Smith L,Brambilla R,Palin E,Valori M,Eerola-Rautio J,Tienari P,Corti O,Dunnett SB,Ganley IG,Suomalainen A,Muqit MMK
Wed Nov 07 00:00:00 EST 2018
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway.
Science advances
Heo JM,Ordureau A,Swarup S,Paulo JA,Shen K,Sabatini DM,Harper JW
Thu Nov 01 00:00:00 EDT 2018
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nature structural & molecular biology
Gersch M,Gladkova C,Schubert AF,Michel MA,Maslen S,Komander D
Wed Nov 01 00:00:00 EDT 2017
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
ACS chemical neuroscience
Geldenhuys WJ,Benkovic SA,Lin L,Yonutas HM,Crish SD,Sullivan PG,Darvesh AS,Brown CM,Richardson JR
Wed Dec 20 00:00:00 EST 2017
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
ACS chemical neuroscience
Geldenhuys WJ,Benkovic SA,Lin L,Yonutas HM,Crish SD,Sullivan PG,Darvesh AS,Brown CM,Richardson JR
Wed Dec 20 00:00:00 EST 2017
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
ACS chemical neuroscience
Geldenhuys WJ,Benkovic SA,Lin L,Yonutas HM,Crish SD,Sullivan PG,Darvesh AS,Brown CM,Richardson JR
Wed Dec 20 00:00:00 EST 2017
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
ACS chemical neuroscience
Geldenhuys WJ,Benkovic SA,Lin L,Yonutas HM,Crish SD,Sullivan PG,Darvesh AS,Brown CM,Richardson JR
Wed Dec 20 00:00:00 EST 2017
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
ACS chemical neuroscience
Geldenhuys WJ,Benkovic SA,Lin L,Yonutas HM,Crish SD,Sullivan PG,Darvesh AS,Brown CM,Richardson JR
Wed Dec 20 00:00:00 EST 2017
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in mice.
World journal of gastrointestinal pathophysiology
Heritage M,Jaskowski L,Bridle K,Campbell C,Briskey D,Britton L,Fletcher L,Vitetta L,Subramaniam VN,Crawford D
Mon May 15 00:00:00 EDT 2017
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in mice.
World journal of gastrointestinal pathophysiology
Heritage M,Jaskowski L,Bridle K,Campbell C,Briskey D,Britton L,Fletcher L,Vitetta L,Subramaniam VN,Crawford D
Mon May 15 00:00:00 EDT 2017
MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
The Journal of biological chemistry
Hu X,Jogasuria A,Wang J,Kim C,Han Y,Shen H,Wu J,You M
Fri Oct 21 00:00:00 EDT 2016
MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
The Journal of biological chemistry
Hu X,Jogasuria A,Wang J,Kim C,Han Y,Shen H,Wu J,You M
Fri Oct 21 00:00:00 EDT 2016
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.
The Journal of biological chemistry
Ko YH,Domingo-Vidal M,Roche M,Lin Z,Whitaker-Menezes D,Seifert E,Capparelli C,Tuluc M,Birbe RC,Tassone P,Curry JM,Navarro-Sabaté À,Manzano A,Bartrons R,Caro J,Martinez-Outschoorn U
Fri Dec 16 00:00:00 EST 2016
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.
The Journal of biological chemistry
Ko YH,Domingo-Vidal M,Roche M,Lin Z,Whitaker-Menezes D,Seifert E,Capparelli C,Tuluc M,Birbe RC,Tassone P,Curry JM,Navarro-Sabaté À,Manzano A,Bartrons R,Caro J,Martinez-Outschoorn U
Fri Dec 16 00:00:00 EST 2016
Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
The EMBO journal
Lai YC,Kondapalli C,Lehneck R,Procter JB,Dill BD,Woodroof HI,Gourlay R,Peggie M,Macartney TJ,Corti O,Corvol JC,Campbell DG,Itzen A,Trost M,Muqit MM
Thu Nov 12 00:00:00 EST 2015
Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
The EMBO journal
Lai YC,Kondapalli C,Lehneck R,Procter JB,Dill BD,Woodroof HI,Gourlay R,Peggie M,Macartney TJ,Corti O,Corvol JC,Campbell DG,Itzen A,Trost M,Muqit MM
Thu Nov 12 00:00:00 EST 2015
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.
Proceedings of the National Academy of Sciences of the United States of America
Ordureau A,Heo JM,Duda DM,Paulo JA,Olszewski JL,Yanishevski D,Rinehart J,Schulman BA,Harper JW
Tue May 26 00:00:00 EDT 2015
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.
Proceedings of the National Academy of Sciences of the United States of America
Ordureau A,Heo JM,Duda DM,Paulo JA,Olszewski JL,Yanishevski D,Rinehart J,Schulman BA,Harper JW
Tue May 26 00:00:00 EDT 2015
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
EMBO reports
Kazlauskaite A,Martínez-Torres RJ,Wilkie S,Kumar A,Peltier J,Gonzalez A,Johnson C,Zhang J,Hope AG,Peggie M,Trost M,van Aalten DM,Alessi DR,Prescott AR,Knebel A,Walden H,Muqit MM
Sat Aug 01 00:00:00 EDT 2015
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
EMBO reports
Kazlauskaite A,Martínez-Torres RJ,Wilkie S,Kumar A,Peltier J,Gonzalez A,Johnson C,Zhang J,Hope AG,Peggie M,Trost M,van Aalten DM,Alessi DR,Prescott AR,Knebel A,Walden H,Muqit MM
Sat Aug 01 00:00:00 EDT 2015
Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shabalina IG,Landreh L,Edgar D,Hou M,Gibanova N,Atanassova N,Petrovic N,Hultenby K,Söder O,Nedergaard J,Svechnikov K
Sat Aug 01 00:00:00 EDT 2015
Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shabalina IG,Landreh L,Edgar D,Hou M,Gibanova N,Atanassova N,Petrovic N,Hultenby K,Söder O,Nedergaard J,Svechnikov K
Sat Aug 01 00:00:00 EDT 2015
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Molecular cell
Ordureau A,Sarraf SA,Duda DM,Heo JM,Jedrychowski MP,Sviderskiy VO,Olszewski JL,Koerber JT,Xie T,Beausoleil SA,Wells JA,Gygi SP,Schulman BA,Harper JW
Thu Nov 06 00:00:00 EST 2014
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Molecular cell
Ordureau A,Sarraf SA,Duda DM,Heo JM,Jedrychowski MP,Sviderskiy VO,Olszewski JL,Koerber JT,Xie T,Beausoleil SA,Wells JA,Gygi SP,Schulman BA,Harper JW
Thu Nov 06 00:00:00 EST 2014
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
The Journal of cell biology
Lazarou M,Narendra DP,Jin SM,Tekle E,Banerjee S,Youle RJ
Mon Jan 21 00:00:00 EST 2013
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
The Journal of cell biology
Lazarou M,Narendra DP,Jin SM,Tekle E,Banerjee S,Youle RJ
Mon Jan 21 00:00:00 EST 2013
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
The Journal of cell biology
Lazarou M,Narendra DP,Jin SM,Tekle E,Banerjee S,Youle RJ
Mon Jan 21 00:00:00 EST 2013
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
The Journal of cell biology
Lazarou M,Narendra DP,Jin SM,Tekle E,Banerjee S,Youle RJ
Mon Jan 21 00:00:00 EST 2013
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Human molecular genetics
Narendra DP,Wang C,Youle RJ,Walker JE
Mon Jul 01 00:00:00 EDT 2013
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Human molecular genetics
Narendra DP,Wang C,Youle RJ,Walker JE
Mon Jul 01 00:00:00 EDT 2013
Isolation of sarcolemmal plasma membranes by mechanically skinning rat skeletal muscle fibers for phospholipid analysis.
Lipids
Fajardo VA,McMeekin L,Basic A,Lamb GD,Murphy RM,LeBlanc PJ
Mon Apr 01 00:00:00 EDT 2013
Isolation of sarcolemmal plasma membranes by mechanically skinning rat skeletal muscle fibers for phospholipid analysis.
Lipids
Fajardo VA,McMeekin L,Basic A,Lamb GD,Murphy RM,LeBlanc PJ
Mon Apr 01 00:00:00 EDT 2013