Proteintech

NR4A2 Monoclonal Antibody (1H5B4), CoraLite® Plus 488

View all (44) Nurr1 antibodies
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Datasheet
Protocols
Questions & Answers

Product Details

CL488-66878

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.8 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1H5B4

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Purification

Protein G

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: SPPSRGSPSN EGLCAVCGDN AACQHYGVRT CEGCKGFFKR TVQKNAKYVC LANKNCPVDK RRRNRCQYCR FQKCLAVGMV KEVVRTDSLK GRRGRLPSKP KSPQEPSPPS PPVSLISALV RAHVDSNPAM TSLDYSRFQA NPDYQMSGDD TQHIQQFYDL LTGSMEIIRG WAEKIPGFAD LPKADQDLLF ESAFLELFVL RLAYRSNPVE GKLIFCNGVV LHRLQCVRGF GEWIDSIVEF SSNLQNMNID ISAFSCIAAL AMVTERHGLK EPKRVEELQN KIVNCLKDHV TFNNGGLNRP NYLSKLLGKL PELRTLCTQG LQRIFYLKLE DLVPPPAIID KLFLDTLPF

Target Information

The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HZF3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B beta; NGFI-B/nur77 beta-type transcription factor homolog; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4, group A, member 2; nur related protein 1; nur related protein-1, human homolog of; NUR-related factor 1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor

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Gene Aliases: HZF-3; NOT; NR4A2; NURR1; RNR-1; RNR1; TINOR; TINUR

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UniProt ID: (Human) P43354, (Mouse) Q06219

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Entrez Gene ID: (Human) 4929, (Mouse) 18227

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding beta-catenin binding zinc ion binding glucocorticoid receptor binding protein homodimerization activity retinoid X receptor binding protein heterodimerization activity RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia neuron migration response to amphetamine transcription, DNA-templated transcription initiation from RNA polymerase II promoter signal transduction adult locomotory behavior post-embryonic development central nervous system projection neuron axonogenesis habenula development intracellular receptor signaling pathway cellular response to extracellular stimulus cellular response to oxidative stress regulation of dopamine metabolic process dopamine biosynthetic process neuron maturation positive regulation of catalytic activity steroid hormone mediated signaling pathway negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange fat cell differentiation positive regulation of transcription from RNA polymerase II promoter general adaptation syndrome canonical Wnt signaling pathway cellular response to corticotropin-releasing hormone stimulus dopaminergic neuron differentiation midbrain dopaminergic neuron differentiation negative regulation of apoptotic signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter nervous system development response to inorganic substance gene expression regulation of gene expression obsolete death response to insecticide central nervous system neuron differentiation neuron differentiation dopamine metabolic process positive regulation of transcription, DNA-templated
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