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RAB11A Antibody (CL488-67902) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human RAB11A (CL488-67902, Clone:4A4C9) (red), or 0.4 µg Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-67902
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4A4C9
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24KG; RAB 11A, member oncogene family; Rab-11; Ras-related protein Rab-11A; YL8
Gene Aliases: RAB11; RAB11A; YL8
UniProt ID: (Pig) Q52NJ1, (Human) P62491, (Rat) P62494, (Mouse) P62492
Entrez Gene ID: (Pig) 595117, (Human) 8766, (Rat) 81830, (Mouse) 53869
intracellular protein transport
exocytosis
mitotic metaphase plate congression
metabolic process
positive regulation of epithelial cell migration
regulation of multivesicular body size
positive regulation of G2/M transition of mitotic cell cycle
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
Rab protein signal transduction
multivesicular body assembly
positive regulation of axon extension
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
exosomal secretion
intracellular cholesterol transport
regulation of cytokinesis
amyloid-beta clearance by transcytosis
cytokinesis
renal water homeostasis
small GTPase mediated signal transduction
protein transport
plasma membrane to endosome transport
transport
cell cycle
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