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Proteintech
NRF2/NFE2L2 Recombinant Rabbit Monoclonal Antibody (1I21), CoraLite® Plus 488
FIGURE: 1 / 1
NRF2/NFE2L2 Antibody (CL488-80593) in Flow
1X10^6 MCF-7 cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human NRF2, NFE2L2 (CL488-80593, Clone:1I21) (red), or 0.8 µg Isotype Control. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-80593
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1I21
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SILSTEDPNQ LTVNSLNSDA TVNTDFGDEF YSAFIAEPSI SNSMPSPATL SHSLSELLNG PIDVSDLSLC KAFNQNHPES TAEFNDSDSG ISLNTSPSVA SPEHSVESSS YGDTLLGLSD SEVEELDSAP GSVKQNGPKT PVHSSGDMVQ PLSPSQGQST HVHDAQCENT PEKELPVSPG HRKTPFTKDK HSSRLEAHLT RDELRAKALH IPFPVEKIIN LPVVDFNEMM SKEQFNEAQL ALIRDIRRRG KNKVAAQNCR KRKLENIVEL EQDLDHLKDE KEKLLKEKGE NDKSLHLLKK QLSTLYLEVF SMLRDEDGKP YSPSEYSLQQ TRDGNVFLVP KSKKPDVKKN
Target Information
Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E4TF1-60; E4TF1A; NF-E2-related factor 2; NFE2-related factor 2; NFT2; NRF2A; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2-like 2; Nuclear factor, erythroid derived 2, like 2
Gene Aliases: AI194320; HEBP1; NFE2L2; NRF2
UniProt ID: (Human) Q16236, (Mouse) Q60795
Entrez Gene ID: (Human) 4780, (Mouse) 18024
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
transcription regulatory region DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
transcription from RNA polymerase II promoter
inflammatory response
proteasomal ubiquitin-independent protein catabolic process
positive regulation of gene expression
protein ubiquitination
positive regulation of blood coagulation
endoplasmic reticulum unfolded protein response
cellular response to oxidative stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
cell redox homeostasis
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
positive regulation of glucose import
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
negative regulation of hematopoietic stem cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of hydrogen peroxide-induced cell death
positive regulation of glutathione biosynthetic process
regulation of removal of superoxide radicals
negative regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
response to endoplasmic reticulum stress
positive regulation of transcription, DNA-templated
negative regulation of cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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