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Product Details
CL594-66885
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1F1B9
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ESLTDKVILD VGCGTGIISL FCAHYARPRA VYAVEASEMA QHTGQLVLQN GFADIITVYQ QKVEDVVLPE KVDVLVSEWM GTCLLFEFMI ESILYARDAW LKEDGVIWPT MAALHLVPCS ADKDYRSKVL FWDNAYEFNL SALKSLAVKE FFSKPKYNHI LKPEDCLSEP CTILQLDMRT VQISDLETLR GELRFDIRKA GTLHGFTAWF SVHFQSLQEG QPPQVLSTGP FHPTTHWKQT LFMMDDPVPV HTGDVVTGSV VLQRNPVWIR HMSVALSWAV TSRQDPTSQK VGEKVFPIWR
Target Information
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; Protein arginine N-methyltransferase 2
Gene Aliases: AI504737; HMT1; HRMT1L1; PRMT2
UniProt ID: (Human) P55345
Entrez Gene ID: (Human) 3275, (Mouse) 15468, (Rat) 499420
transcription coactivator activity
signal transducer activity
protein binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
androgen receptor binding
molecular_function
cytokine activity
tumor necrosis factor receptor binding
beta-catenin binding
protein modifying enzyme
protein methylation
signal transduction
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
negative regulation of NF-kappaB transcription factor activity
histone arginine methylation
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
developmental cell growth
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
response to hypoxia
immune response
biological_process
peptidyl-arginine N-methylation
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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