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Product Details
14402-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLCNKA Fusion Protein Ag5647 (515-687 aa encoded by BC048282)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CQPSFYDGT IIVKKLPYLP RILGRNIGSH HVRVEHFMNH SITTLAKDTP LEEVVKVVTS TDVTEYPLVE STESQILVGI VQRAQLVQAL QAEPPSRAPG HQQCLQDILA RGCPTEPVTL TLFSETTLHQ AQNLFKLLNL QSLFVTSRGR AVGCVSWVEM KKAISNLTNP PAPK (515-687 aa encoded by B C048282)
Target Information
CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel K1; Chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; ClC-K1; CLC-KA; CLCKA; putative basolateral cTAL chloride channel ClC-Ka
Gene Aliases: C75963; CLC-K1; CLCK1; Clcnk1; CLCNKA; hClC-Ka
UniProt ID: (Human) P51800, (Mouse) Q9WUB7, (Rat) Q06393
Entrez Gene ID: (Human) 1187, (Mouse) 12733, (Rat) 79425
transport
excretion
ion transmembrane transport
chloride transmembrane transport
regulation of anion transmembrane transport
ion transport
chloride transport
regulation of ion transmembrane transport
regulation of body fluid levels
transmembrane transport
renal inner medulla development
kidney development
body fluid secretion
response to pH
response to water deprivation
regulation of anion transport
response to calcium ion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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