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Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 ).
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Protein Aliases: bifurcated 2; Chronic lymphocytic leukemia deletion region gene 8 protein; CLLL8 protein; DKFZp586I0123; DKFZp761J1217; Histone-lysine N-methyltransferase SETDB2; Lysine N-methyltransferase 1F; SET domain; SET domain bifurcated 2; Setdb2-Phf11-1-Phf11-2 fusion
Gene Aliases: C13orf4; CLLD8; CLLL8; Gm293; KMT1F; SETDB2
UniProt ID: (Human) Q96T68
Entrez Gene ID: (Human) 83852, (Mouse) 239122
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