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Antibody detects endogenous levels of total CNGB3.
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
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Protein Aliases: cng channel; CNG channel beta-3; cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor cGMP-gated channel subunit beta; cyclic nucleotide gated channel beta 6; Cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; Cyclic nucleotide-gated channel subunit CNG6
Gene Aliases: ACHM1; CCNC2; CNG6; CNGB3; Cngbeta2
UniProt ID: (Human) Q9NQW8, (Mouse) Q9JJZ9
Entrez Gene ID: (Human) 54714, (Mouse) 30952
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