Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Dog, Orangutan, Monkey, Gorilla, Chimpanzee, Greater horseshoe bat, Small-eared galago and Gray short-tailed opossum
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CCR4-NOT transcription complex, subunit 3; Leukocyte receptor cluster member 2; NOT3 (negative regulator of transcription 3, yeast) homolog
Gene Aliases: CNOT3; KIAA0691; LENG2; NOT3; NOT3H
UniProt ID: (Human) O75175
Entrez Gene ID: (Human) 4849
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