Proteintech

CNOT7 Polyclonal Antibody

FIGURE: 1 / 3

CNOT7 Antibody (14102-1-AP) in WB

Mouse testis tissue were subjected to SDS PAGE followed by western blot with 14102-1-AP (CNOT7 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

CNOT7 Antibody in Immunoprecipitation (IP)

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Product Details

14102-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CNOT7 Fusion Protein Ag5235 (1-285 aa encoded by BC060852)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPAATVDHS QRICEVWACN LDEEMKKIRQ VIRKYNYVAM DTEFPGVVAR PIGEFRSNAD YQYQLLRCNV DLLKIIQLGL TFMNEQGEYP PGTSTWQFNF KFNLTEDMYA QDSIELLTTS GIQFKKHEEE GIETQYFAEL LMTSGVVLCE GVKWLSFHSG YDFGYLIKIL TNSNLPEEEL DFFEILRLFF PVIYDVKYLM KSCKNLKGGL QEVAEQLELE RIGPQHQAGS DSLLTGMAFF KMREMFFEDH IDDAKYCGHL YGLGSGSSYV QNGTGNAYEE EANKQS (1-285 aa encoded by B C060852)

Target Information

CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BESST: a novel LncRNA knockout strategy with less genome perturbance.

Nucleic acids research

Zhang S,Chen Y,Dong K,Zhao Y,Wang Y,Wang S,Qu C,Xu N,Xie W,Zeng C,Lyu QR,Zhang Y

Mon May 22 00:00:00 EDT 2023

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.

Nature communications

Matkovic R,Morel M,Lanciano S,Larrous P,Martin B,Bejjani F,Vauthier V,Hansen MMK,Emiliani S,Cristofari G,Gallois-Montbrun S,Margottin-Goguet F

Mon Jan 10 00:00:00 EST 2022

The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain.

Journal of inflammation (London, England)

Hsieh HH,Chen YA,Chang YJ,Wang HH,Yu YH,Lin SW,Huang YJ,Lin S,Chang CJ

Sat Jun 05 00:00:00 EDT 2021

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).

Cells

Duan TL,Jiao H,He GJ,Yan YB

Thu Jan 09 00:00:00 EST 2020

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Nature

Yamaji M,Jishage M,Meyer C,Suryawanshi H,Der E,Yamaji M,Garzia A,Morozov P,Manickavel S,McFarland HL,Roeder RG,Hafner M,Tuschl T

Thu Mar 23 00:00:00 EDT 2017

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Nature

Yamaji M,Jishage M,Meyer C,Suryawanshi H,Der E,Yamaji M,Garzia A,Morozov P,Manickavel S,McFarland HL,Roeder RG,Hafner M,Tuschl T

Thu Mar 23 00:00:00 EDT 2017

B cell translocation gene 1 reduces the biological outcome of kidney cancer through induction of cell proliferation, cell cycle arrest, cell apoptosis and cell metastasis.

International journal of molecular medicine

Sun G,Liu Q,Cheng Y,Hu W

Sun Mar 01 00:00:00 EST 2015

B cell translocation gene 1 reduces the biological outcome of kidney cancer through induction of cell proliferation, cell cycle arrest, cell apoptosis and cell metastasis.

International journal of molecular medicine

Sun G,Liu Q,Cheng Y,Hu W

Sun Mar 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: BTG1-binding factor 1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; POP2 homolog

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Gene Aliases: AU022737; CAF-1; CAF1; Caf1a; CNOT7; hCAF-1; Pop2

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UniProt ID: (Human) Q9UIV1, (Mouse) Q60809

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Entrez Gene ID: (Human) 29883, (Mouse) 18983, (Rat) 306492

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Function(s)

3'-5'-exoribonuclease activity transcription factor activity, sequence-specific DNA binding RNA binding exoribonuclease activity poly(A)-specific ribonuclease activity signal transducer activity protein binding metal ion binding nucleic acid binding nuclease activity exonuclease activity hydrolase activity mRNA polyadenylation factor

Process(es)

nuclear-transcribed mRNA poly(A) tail shortening deadenylation-dependent decapping of nuclear-transcribed mRNA carbohydrate metabolic process transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of gene expression gene silencing by RNA cytoplasmic mRNA processing body assembly gene silencing by miRNA exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay positive regulation of transcription from RNA polymerase II promoter positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of mRNA catabolic process RNA phosphodiester bond hydrolysis, exonucleolytic positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription, DNA-templated regulation of translation nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CNOT7 Polyclonal Antibody

CNOT7 Antibody (14102-1-AP) in WB

Product Details

14102-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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