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Product Details
10752-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CNOT8 Fusion Protein Ag1201 (1-292 aa encoded by BC017366)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against the full-length human CNOT8.
Immunogen sequence: MPAALVENS QVICEVWASN LEEEMRKIRE IVLSYSYIAM DTEFPGVVVR PIGEFRSSID YQYQLLRCNV DLLKIIQLGL TFTNEKGEYP SGINTWQFNF KFNLTEDMYS QDSIDLLANS GLQFQKHEEE GIDTLHFAEL LMTSGVVLCD NVKWLSFHSG YDFGYMVKLL TDSRLPEEEH EFFHILNLFF PSIYDVKYLM KSCKNLKGGL QEVADQLDLQ RIGRQHQAGS DSLLTGMAFF RMKELFFEDS IDDAKYCGRL YGLGTGVAQK QNEDVDSAQE KMSILAIINN MQQ (1-292 aa encoded by BC017366)
Target Information
CNOT8 (CCR4-NOT transcription complex subunit 8), also known as CALIF or POP2, is a 292 amino acid protein that localizes to both the nucleus and the cytoplasm and functions as part of the CCR-NOT complex. Expressed ubiquitously, CNOT8 plays a role in transcriptional regulation for a diverse set of processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CAF1-like protein; Caf1b; CAF2; CALIFp; CCR4-associated factor 8; CCR4-NOT transcription complex subunit 8; CCR4-NOT transcription complex, subunit 8; h CAF1-like protein; PGK promoter directed over production
Gene Aliases: 1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059; CAF1; Caf1b; CALIF; CNOT8; hCAF1; POP2
UniProt ID: (Human) Q9UFF9, (Mouse) Q9D8X5
Entrez Gene ID: (Human) 9337, (Mouse) 69125, (Rat) 363603
3'-5'-exoribonuclease activity
transcription factor activity, sequence-specific DNA binding
RNA binding
poly(A)-specific ribonuclease activity
protein binding
metal ion binding
nucleic acid binding
nuclease activity
exonuclease activity
hydrolase activity
molecular_function
mRNA polyadenylation factor
nuclear-transcribed mRNA poly(A) tail shortening
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cell proliferation
negative regulation of cell proliferation
gene silencing by miRNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
positive regulation of mRNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of translation
gene silencing by RNA
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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