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COG2 Antibody (PA5-76872) in IHC (P)
Immunohistochemistry analysis of COG2 in paraffin-embedded mouse kidney. Samples were incubated with COG2 polyclonal antibody (Product # PA5-76872) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-76872
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human COG2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2720599
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brefeldin A-sensitive, peripheral Golgi protein; COG 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; conserved oligomeric Golgi complex protein 2; Conserved oligomeric Golgi complex subunit 2; low density lipoprotein receptor defect C complementing; Low density lipoprotein receptor defect C-complementing protein; Transcript ch4822
Gene Aliases: 1190002B08Rik; 2700012E02Rik; C86089; COG2; LDLC
UniProt ID: (Human) Q14746, (Mouse) Q921L5
Entrez Gene ID: (Human) 22796, (Mouse) 76332, (Rat) 690961
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