Proteintech

COQ5 Polyclonal Antibody

COQ5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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COQ5 Antibody (17453-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 17453-1-AP (COQ5 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

17453-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COQ5 Fusion Protein Ag10203 (1-327 aa encoded by BC107874)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAPGSCAL WSYCGRGWSR AMRGCQLLGL RSSWPGDLLS ARLLSQEKRA AETHFGFETV SEEEKGGKVY QVFESVAKKY DVMNDMMSLG IHRVWKDLLL WKMHPLPGTQ LLDVAGGTGD IAFRFLNYVQ SQHQRKQKRQ LRAQQNLSWE EIAKEYQNEE DSLGGSRVVV CDINKEMLKV GKQKALAQGY RAGLAWVLGD AEELPFDDDK FDIYTIAFGI RNVTHIDQAL QEAHRVLKPG GRFLCLEFSQ VNNPLISRLY DLYSFQVIPV LGEVIAGDWK SYQYLVESIR RFPSQEEFKD MIEDAGFHKV TYESLTSGIV AIHSGFKL (1-327 aa encoded by BC107874)

Target Information

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitochondrial dysfunction and calcium dysregulation in COQ8A-ataxia Purkinje neurons are rescued by CoQ10 treatment.

Brain : a journal of neurology

Manolaras I,Del Bondio A,Griso O,Reutenauer L,Eisenmann A,Habermann BH,Puccio H

Fri Sep 01 00:00:00 EDT 2023

Mitochondrial dysfunction and calcium dysregulation in COQ8A-ataxia Purkinje neurons are rescued by CoQ10 treatment.

Brain : a journal of neurology

Manolaras I,Del Bondio A,Griso O,Reutenauer L,Eisenmann A,Habermann BH,Puccio H

Fri Sep 01 00:00:00 EDT 2023

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.

Redox biology

González-García P,Díaz-Casado ME,Hidalgo-Gutiérrez A,Jiménez-Sánchez L,Bakkali M,Barriocanal-Casado E,Escames G,Chiozzi RZ,Völlmy F,Zaal EA,Berkers CR,Heck AJR,López LC

Thu Sep 01 00:00:00 EDT 2022

Implication of folate deficiency in CYP2U1 loss of function.

The Journal of experimental medicine

Pujol C,Legrand A,Parodi L,Thomas P,Mochel F,Saracino D,Coarelli G,Croon M,Popovic M,Valet M,Villain N,Elshafie S,Issa M,Zuily S,Renaud M,Marelli-Tosi C,Legendre M,Trimouille A,Kemlin I,Mathieu S,Gleeson JG,Lamari F,Galatolo D,Alkouri R,Tse C,Rodriguez D,Ewenczyk C,Fellmann F,Kuntzer T,Blond E,El Hachimi KH,Darios F,Seyer A,Gazi AD,Giavalisco P,Perin S,Boucher JL,Le Corre L,Santorelli FM,Goizet C,Zaki MS,Picaud S,Mourier A,Steculorum SM,Mignot C,Durr A,Trifunovic A,Stevanin G

Mon Nov 01 00:00:00 EDT 2021

ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment.

Journal of the American Society of Nephrology : JASN

Widmeier E,Yu S,Nag A,Chung YW,Nakayama M,Fernández-Del-Río L,Hugo H,Schapiro D,Buerger F,Choi WI,Helmstädter M,Kim JW,Ryu JH,Lee MG,Clarke CF,Hildebrandt F,Gee HY

Mon Jun 01 00:00:00 EDT 2020

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 EST 2019

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 EST 2019

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Scientific reports

Rodríguez-Hidalgo M,Luna-Sánchez M,Hidalgo-Gutiérrez A,Barriocanal-Casado E,Mascaraque C,Acuña-Castroviejo D,Rivera M,Escames G,López LC

Tue Sep 18 00:00:00 EDT 2018

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Scientific reports

Rodríguez-Hidalgo M,Luna-Sánchez M,Hidalgo-Gutiérrez A,Barriocanal-Casado E,Mascaraque C,Acuña-Castroviejo D,Rivera M,Escames G,López LC

Tue Sep 18 00:00:00 EDT 2018

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

EMBO molecular medicine

Luna-Sánchez M,Díaz-Casado E,Barca E,Tejada MÁ,Montilla-García Á,Cobos EJ,Escames G,Acuña-Castroviejo D,Quinzii CM,López LC

Fri May 01 00:00:00 EDT 2015

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

EMBO molecular medicine

Luna-Sánchez M,Díaz-Casado E,Barca E,Tejada MÁ,Montilla-García Á,Cobos EJ,Escames G,Acuña-Castroviejo D,Quinzii CM,López LC

Fri May 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; coenzyme Q5 homolog, methyltransferase; Ubiquinone biosynthesis methyltransferase COQ5; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial

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Gene Aliases: 1810014G04Rik; COQ5; D5Ertd33e

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UniProt ID: (Human) Q5HYK3, (Mouse) Q9CXI0

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Entrez Gene ID: (Human) 84274, (Mouse) 52064

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Function(s)

S-adenosylmethionine-dependent methyltransferase activity 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity methyltransferase activity transferase activity methyltransferase

Process(es)

ubiquinone biosynthetic process methylation biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COQ5 Polyclonal Antibody

COQ5 Antibody (17453-1-AP) in IHC (P)

Product Details

17453-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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