Proteintech

COX17 Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (7)

COX17 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

COX17 Antibody (11464-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HeLa cells using 11464-1-AP (COX17 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

COX17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

11464-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COX17 Fusion Protein Ag2032 (1-63 aa encoded by BC010933)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPGLVDSNP APPESQEKKP LKPCCACPET KKARDACIIE KGEEHCGHLI EAHKECMRAL GFKI (1-63 aa encoded by BC010933)

Target Information

Cytochrome c oxidase 17 (COX17) is a nuclear gene encoding an assembly protein necessary for proper COX apoenzyme-dependent mitochondrial respiration. The mammalian COX apoenzyme is a heteromer consisting of three mitochondrial genes that encode catalytic subunits and several nuclear genes that encode structural subunits. COX17 influences the recruitment of copper to the mitochondria for incorporation into the COX apoenzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitochondrial respiration reduces exposure of the nucleus to oxygen.

The Journal of biological chemistry

Mori MP,Penjweini R,Ma J,Alspaugh G,Andreoni A,Kim YC,Wang PY,Knutson JR,Hwang PM

Wed Mar 01 00:00:00 EST 2023

COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.

Acta pharmacologica Sinica

Zhu SY,Zhou WQ,Niu YY,Zheng C,Liu X,Zhang YY,Yu C

Sun Oct 01 00:00:00 EDT 2023

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.

Nucleic acids research

Jia Z,Meng F,Chen H,Zhu G,Li X,He Y,Zhang L,He X,Zhan H,Chen M,Ji Y,Wang M,Guan MX

Fri Sep 09 00:00:00 EDT 2022

Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Abdelsaid K,Sudhahar V,Harris RA,Das A,Youn SW,Liu Y,McMenamin M,Hou Y,Fulton D,Hamrick MW,Tang Y,Fukai T,Ushio-Fukai M

Tue Mar 01 00:00:00 EST 2022

Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.

Neurotoxicology

Goyal S,Tiwari S,Seth B,Tandon A,Shankar J,Sinha M,Singh SJ,Priya S,Chaturvedi RK

Thu Jul 01 00:00:00 EDT 2021

Discovery of bactericides as an acute mitochondrial membrane damage inducer.

Molecular biology of the cell

Houston R,Sekine Y,Larsen MB,Murakami K,Mullett SJ,Wendell SG,Narendra DP,Chen BB,Sekine S

Mon Nov 01 00:00:00 EDT 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 EDT 2021

Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy.

Frontiers in physiology

Liaghati A,Pileggi CA,Parmar G,Patten DA,Hadzimustafic N,Cuillerier A,Menzies KJ,Burelle Y,Harper ME

Fri Mar 26 00:00:00 EDT 2021

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.

Cell stem cell

Singh RP,Jeyaraju DV,Voisin V,Hurren R,Xu C,Hawley JR,Barghout SH,Khan DH,Gronda M,Wang X,Jitkova Y,Sharon D,Liyanagae S,MacLean N,Seneviratene AK,Mirali S,Borenstein A,Thomas GE,Soriano J,Orouji E,Minden MD,Arruda A,Chan SM,Bader GD,Lupien M,Schimmer AD

Thu Jun 04 00:00:00 EDT 2020

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.

Cell stem cell

Thu Jun 04 00:00:00 EDT 2020

Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.

American journal of physiology. Cell physiology

Das A,Sudhahar V,Ushio-Fukai M,Fukai T

Sun Dec 01 00:00:00 EST 2019

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

EMBO molecular medicine

Mohanraj K,Wasilewski M,Benincá C,Cysewski D,Poznanski J,Sakowska P,Bugajska Z,Deckers M,Dennerlein S,Fernandez-Vizarra E,Rehling P,Dadlez M,Zeviani M,Chacinska A

Wed May 01 00:00:00 EDT 2019

Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.

Molecular medicine (Cambridge, Mass.)

Song G,Napoli E,Wong S,Hagerman R,Liu S,Tassone F,Giulivi C

Sat Oct 01 00:00:00 EDT 2016

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

American journal of human genetics

Di Fonzo A,Ronchi D,Lodi T,Fassone E,Tigano M,Lamperti C,Corti S,Bordoni A,Fortunato F,Nizzardo M,Napoli L,Donadoni C,Salani S,Saladino F,Moggio M,Bresolin N,Ferrero I,Comi GP

Fri May 01 00:00:00 EDT 2009

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

American journal of human genetics

Di Fonzo A,Ronchi D,Lodi T,Fassone E,Tigano M,Lamperti C,Corti S,Bordoni A,Fortunato F,Nizzardo M,Napoli L,Donadoni C,Salani S,Saladino F,Moggio M,Bresolin N,Ferrero I,Comi GP

Fri May 01 00:00:00 EDT 2009

Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.

Toxicology and applied pharmacology

Miyayama T,Suzuki KT,Ogra Y

Mon Jun 01 00:00:00 EDT 2009

Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.

Toxicology and applied pharmacology

Miyayama T,Suzuki KT,Ogra Y

Mon Jun 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: COX17 cytochrome c oxidase assembly homolog; COX17 cytochrome c oxidase copper chaperone; COX17 homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase 17 copper chaperone; cytochrome c oxidase assembly homolog 17; Cytochrome c oxidase copper chaperone; cytochrome c oxidase subunit XVII assembly protein homolog; cytochrome c oxidase, subunit XVII assembly protein homolog; human homolog of yeast mitochondrial copper recruitment

View more View less

Gene Aliases: AI037035; COX17; Cox17a

View more View less

UniProt ID: (Human) Q14061, (Mouse) P56394

View more View less

Entrez Gene ID: (Human) 10063, (Rat) 89786, (Mouse) 12856

View more View less

Function(s)

copper ion binding protein binding copper chaperone activity molecular_function enzyme activator activity chaperone

Process(es)

generation of precursor metabolites and energy copper ion transport brain development heart development mitochondrial respiratory chain complex IV assembly positive regulation of catalytic activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

COX17 Polyclonal Antibody

COX17 Antibody (11464-1-AP) in ICC/IF

Product Details

11464-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!