Proteintech

COX2/ Cyclooxygenase 2 Monoclonal Antibody (3G2B9)

COX2/ Cyclooxygenase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

COX2/ Cyclooxygenase 2 Antibody (66351-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66351-1-IG ( COX2/ Cyclooxygenase 2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

COX2/ Cyclooxygenase 2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

COX2/ Cyclooxygenase 2 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

66351-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 78 publications 78 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3G2B9

Immunogen

COX2/ Cyclooxygenase 2 Fusion Protein Ag24721 (20-370 aa encoded by BC013734)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PCCSHPCQN RGVCMSVGFD QYKCDCTRTG FYGENCSTPE FLTRIKLFLK PTPNTVHYIL THFKGFWNVV NNIPFLRNAI MSYVLTSRSH LIDSPPTYNA DYGYKSWEAF SNLSYYTRAL PPVPDDCPTP LGVKGKKQLP DSNEIVEKLL LRRKFIPDPQ GSNMMFAFFA QHFTHQFFKT DHKRGPAFTN GLGHGVDLNH IYGETLARQR KLRLFKDGKM KYQIIDGEMY PPTVKDTQAE MIYPPQVPEH LRFAVGQEVF GLVPGLMMYA TIWLREHNRV CDVLKQEHPE WGDEQLFQTS RLILIGETIK IVIEDYVQHL SGYHFKLKFD PELLFNKQFQ YQNRIAAEFN TL (20-370 aa encoded by BC013734)

Target Information

COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins. The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). It is constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and is up-regulated under pathological conditions, such as in cancer and inflammation (in contrast to the iso-enzyme PTGS1, which is expressed ubiquitously). Up-regulation of COX2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX2 is naturally inhibited by calcitriol (the active form of Vitamin D). Glucocorticoids chronically trans-repress PTGS2 gene activity in vivo in part by interfering with transcription initiation and elongation. COX2 is a target of NSAID such as aspirin, which can reduce pain and swelling from inflammation driven by COX2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.

Journal of natural products

Zhang R,Zhang Y,Xin X,Huang G,Zhang N,Zeng Q,Tang L,Attaribo T,Lee KS,Jin BR,Gui Z

Fri May 28 00:00:00 EDT 2021

Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Yin L,Shi C,Zhang Z,Wang W,Li M

Wed Sep 01 00:00:00 EDT 2021

Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice.

Frontiers in nutrition

Huang F,Liu X,Xu S,Hu S,Wang S,Shi D,Wang K,Wang Z,Lin Q,Li S,Zhao S,Jin K,Wang C,Chen L,Wang F

Sun May 01 00:00:00 EDT 2022

Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β.

Journal of natural products

Gao X,Shen X,Zheng Y,Yang L,Zhang X,Hu G,Jia J,Wang A

Fri Nov 26 00:00:00 EST 2021

Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.

Journal of inflammation research

Hu X,Li R,Sun M,Kong Y,Zhu H,Wang F,Wan Q

Fri Apr 22 00:00:00 EDT 2022

Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.

Biochemical pharmacology

Ma ZY,Song XQ,Hu JJ,Wang DB,Ding XJ,Liu RP,Dai ML,Meng FY,Xu JY

Tue Jun 01 00:00:00 EDT 2021

Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 264.7 macrophages.

International journal of biological macromolecules

Hong S,Dia VP,Zhong Q

Wed Dec 15 00:00:00 EST 2021

Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO.

Oxidative medicine and cellular longevity

Su Y,Zhao D,Jin C,Li Z,Sun S,Xia S,Zhang Y,Zhang Z,Zhang F,Xu X,Shao J,Zhang B,Zheng S

Mon Feb 28 00:00:00 EST 2022

Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO.

Oxidative medicine and cellular longevity

Su Y,Zhao D,Jin C,Li Z,Sun S,Xia S,Zhang Y,Zhang Z,Zhang F,Xu X,Shao J,Zhang B,Zheng S

Mon Feb 28 00:00:00 EST 2022

Multifunctional MnO₂-based nanoplatform-induced ferroptosis and apoptosis for synergetic chemoradiotherapy.

Nanomedicine (London, England)

Li X,Wang Q,Yu S,Zhang M,Liu X,Deng G,Liu Y,Wu S

Mon Nov 01 00:00:00 EDT 2021

Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor: A case report.

World journal of clinical cases

Mo LC,Piao SZ,Zheng HH,Hong T,Feng Q,Ke M

Wed Jun 16 00:00:00 EDT 2021

H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.

Technology and health care : official journal of the European Society for Engineering and Medicine

Li Y,Chandra TP,Song X,Nie L,Liu M,Yi J,Zheng X,Chu C,Yang J

Wed Aug 18 00:00:00 EDT 2021

Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.

The Annals of thoracic surgery

Sakaue T,Hamaguchi M,Aono J,Nakashiro KI,Shikata F,Kawakami N,Oshima Y,Kurata M,Nanba D,Masumoto J,Yamaguchi O,Higashiyama S,Izutani H

Wed Jul 01 00:00:00 EDT 2020

Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β-catenin translocation to the nucleus through activating PI3K/Akt pathway.

Environmental toxicology

Zhao Q,Sun P,Qin S,Liu J

Tue Dec 01 00:00:00 EST 2020

Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.

Food & function

Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X

Tue Dec 01 00:00:00 EST 2020

Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.

Inflammation

Wang W,Yang R,Zhang M,Li J,Peng J,Xu M,Zhao Y,Li H,Pan X

Sat Aug 01 00:00:00 EDT 2020

Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.

BioMed research international

Li R,Liu W,Ou L,Gao F,Li M,Wang L,Wei P,Miao F

Fri Apr 23 00:00:00 EDT 2021

Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.

Neurochemical research

Li W,Goshima Y,Ohshima T

Thu Oct 01 00:00:00 EDT 2020

Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein.

Regenerative therapy

Wu CC,Chen YR,Lu DH,Hsu LH,Yang KC,Sumi S

Mon Jun 01 00:00:00 EDT 2020

Geniposide attenuates Aβ_25-35-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells.

RSC advances

Huang XF,Li JJ,Tao YG,Wang XQ,Zhang RL,Zhang JL,Su ZQ,Huang QH,Deng YH

Tue May 22 00:00:00 EDT 2018

Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Cell metabolism

Pacheu-Grau D,Bareth B,Dudek J,Juris L,Vögtle FN,Wissel M,Leary SC,Dennerlein S,Rehling P,Deckers M

Tue Jun 02 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: COX-2; cyclooxygenase; cyclooxygenase 2; cyclooxygenase 2b; Cyclooxygenase-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PGH synthase 2; PHS II; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); TIS10 protein

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Gene Aliases: COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; Pghs-b; Pghs2; PHS-2; PTGS2; TIS10

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UniProt ID: (Human) P35354, (Mouse) Q05769

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Entrez Gene ID: (Human) 5743, (Mouse) 19225

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Function(s)

peroxidase activity prostaglandin-endoperoxide synthase activity protein binding lipid binding enzyme binding heme binding protein homodimerization activity metal ion binding arachidonate 15-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen dioxygenase activity oxygenase

Process(es)

Performance Guarantee

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COX2/ Cyclooxygenase 2 Monoclonal Antibody (3G2B9)

COX2/ Cyclooxygenase 2 Antibody (66351-1-IG) in IHC (P)

Product Details

66351-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

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Published species

Host/Isotype

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Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

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Target Information

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