Proteintech

COX2/ Cyclooxygenase 2 Monoclonal Antibody (3G2B9)

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Antibody Testing Data (7)

COX2/ Cyclooxygenase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

COX2/ Cyclooxygenase 2 Antibody (66351-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66351-1-IG ( COX2/ Cyclooxygenase 2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

COX2/ Cyclooxygenase 2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

COX2/ Cyclooxygenase 2 Antibody in Western Blot (WB)

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Product Details

66351-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 78 publications 78 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3G2B9

Immunogen

COX2/ Cyclooxygenase 2 Fusion Protein Ag24721 (20-370 aa encoded by BC013734)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PCCSHPCQN RGVCMSVGFD QYKCDCTRTG FYGENCSTPE FLTRIKLFLK PTPNTVHYIL THFKGFWNVV NNIPFLRNAI MSYVLTSRSH LIDSPPTYNA DYGYKSWEAF SNLSYYTRAL PPVPDDCPTP LGVKGKKQLP DSNEIVEKLL LRRKFIPDPQ GSNMMFAFFA QHFTHQFFKT DHKRGPAFTN GLGHGVDLNH IYGETLARQR KLRLFKDGKM KYQIIDGEMY PPTVKDTQAE MIYPPQVPEH LRFAVGQEVF GLVPGLMMYA TIWLREHNRV CDVLKQEHPE WGDEQLFQTS RLILIGETIK IVIEDYVQHL SGYHFKLKFD PELLFNKQFQ YQNRIAAEFN TL (20-370 aa encoded by BC013734)

Target Information

COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins. The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). It is constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and is up-regulated under pathological conditions, such as in cancer and inflammation (in contrast to the iso-enzyme PTGS1, which is expressed ubiquitously). Up-regulation of COX2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX2 is naturally inhibited by calcitriol (the active form of Vitamin D). Glucocorticoids chronically trans-repress PTGS2 gene activity in vivo in part by interfering with transcription initiation and elongation. COX2 is a target of NSAID such as aspirin, which can reduce pain and swelling from inflammation driven by COX2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Fri May 28 00:00:00 EDT 2021

Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Yin L,Shi C,Zhang Z,Wang W,Li M

Wed Sep 01 00:00:00 EDT 2021

Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice.

Frontiers in nutrition

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Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β.

Journal of natural products

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Fri Nov 26 00:00:00 EST 2021

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Journal of inflammation research

Hu X,Li R,Sun M,Kong Y,Zhu H,Wang F,Wan Q

Fri Apr 22 00:00:00 EDT 2022

Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.

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International journal of biological macromolecules

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Cell metabolism

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Bioinformatics

Protein Aliases: COX-2; cyclooxygenase; cyclooxygenase 2; cyclooxygenase 2b; Cyclooxygenase-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PGH synthase 2; PHS II; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); TIS10 protein

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Gene Aliases: COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; Pghs-b; Pghs2; PHS-2; PTGS2; TIS10

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UniProt ID: (Human) P35354, (Mouse) Q05769

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Entrez Gene ID: (Human) 5743, (Mouse) 19225

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Function(s)

peroxidase activity prostaglandin-endoperoxide synthase activity protein binding lipid binding enzyme binding heme binding protein homodimerization activity metal ion binding arachidonate 15-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen dioxygenase activity oxygenase

Process(es)

Performance Guarantee

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COX2/ Cyclooxygenase 2 Monoclonal Antibody (3G2B9)

COX2/ Cyclooxygenase 2 Antibody (66351-1-IG) in IHC (P)

Product Details

66351-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

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Product Specific Information

Target Information

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