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COXIV Monoclonal Antibody (2A7B2)

COXIV Antibody in Immunocytochemistry (ICC/IF)

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COXIV Antibody (66110-1-IG) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using 66110-1-Ig (COXIV antibody, 1:100) at dilution of 1:100 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Mouse IgG (H+L); Red is the staining with alpha Tubulin antibody (11224-1-AP, 1:100).

COXIV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

66110-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:8,000

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2A7B2

Immunogen

COXIV Fusion Protein Ag20551 (1-169 aa encoded by BC021236)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.53 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to COX4I1 and do not cross reacts with COX4I2.

Immunogen sequence: MLATRVFSL VGKRAISTSV CVRAHESVVK SEDFSLPAYM DRRDHPLPEV AHVKHLSASQ KALKEKEKAS WSSLSMDEKV ELYRIKFKES FAEMNRGSNE WKTVVGGAMF FIGFTALVIM WQKHYVYGPL PQSFDKEWVA KQTKRMLDMK VNPIQGLASK WDYEKNEWKK (1-169 aa encoded by BC021236)

Target Information

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX4 (COX4I1) is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1.

Oncogene

Han L,Zhang C,Wang D,Zhang J,Tang Q,Li MJ,Sack MN,Wang L,Zhu L

Wed Mar 01 00:00:00 EST 2023

Mitophagy disorder mediates cardiac deterioration induced by severe hypoglycemia in diabetic mice.

Molecular and cellular endocrinology

Huang C,Huang L,Huang Q,Lin L,Wang L,Wu Y,Wu K,Gao R,Liu X,Liu X,Qi L,Liu L

Fri Sep 15 00:00:00 EDT 2023

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.

Journal of translational medicine

Wang W,Zhang Y,Huang W,Yuan Y,Hong Q,Xie Z,Li L,Chen Y,Li X,Meng Y

Fri Jan 13 00:00:00 EST 2023

Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue.

Journal of oncology

Wu Y,Zhou S,Pi D,Dong Y,Wang W,Ye H,Yi Z,Chen Y,Lin L,Ouyang M

Fri Feb 24 00:00:00 EST 2023

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.

bioRxiv : the preprint server for biology

Wu J,Subbaiah KCV,Hedaya O,Chen S,Munger J,Tang WHW,Yan C,Yao P

Mon May 22 00:00:00 EDT 2023

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.

Nucleic acids research

Jia Z,Meng F,Chen H,Zhu G,Li X,He Y,Zhang L,He X,Zhan H,Chen M,Ji Y,Wang M,Guan MX

Fri Sep 09 00:00:00 EDT 2022

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.

ACS nano

Jin J,Yuan P,Yu W,Lin J,Xu A,Xu X,Lou J,Yu T,Qian C,Liu B,Song J,Li L,Piao Y,Xie T,Shen Y,Tao H,Tang J

Tue Jul 26 00:00:00 EDT 2022

Insulin induces insulin receptor degradation in the liver through EphB4.

Nature metabolism

Liu X,Wang K,Hou S,Jiang Q,Ma C,Zhao Q,Kong L,Chen J,Wang Z,Zhang H,Yuan T,Li Y,Huan Y,Shen Z,Hu Z,Huang Z,Cui B,Li P

Thu Sep 01 00:00:00 EDT 2022

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.

Molecular cell

Schäfer JA,Bozkurt S,Michaelis JB,Klann K,Münch C

Thu Jan 20 00:00:00 EST 2022

Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.

Frontiers in cell and developmental biology

Zhang H,Yan M,Liu T,Wei P,Chai N,Li L,Wang J,Yu X,Lin Y,Qiu B,Zhao Y

Tue Apr 05 00:00:00 EDT 2022

The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.

Microbiome

Xiao W,Su J,Gao X,Yang H,Weng R,Ni W,Gu Y

Sun Apr 17 00:00:00 EDT 2022

A dual Keap1 and p47^phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.

Cell death & disease

Wang ZC,Niu KM,Wu YJ,Du KR,Qi LW,Zhou YB,Sun HJ

Mon Sep 26 00:00:00 EDT 2022

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.

Cell death & disease

Li Q,Chu Y,Li S,Yu L,Deng H,Liao C,Liao X,Yang C,Qi M,Cheng J,Chen G,Huang L

Wed Oct 26 00:00:00 EDT 2022

Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.

Chemico-biological interactions

Zhong Y,Sun D,Yao Y,Liu Q,Guo T,Wang X,Peng X

Tue Mar 01 00:00:00 EST 2022

Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.

Frontiers in cardiovascular medicine

Wang X,Yu S,Jian Y,Pan H,Guo J,Wu J,Guo W

Fri Nov 18 00:00:00 EST 2022

Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.

Science (New York, N.Y.)

Wang Q,Guan Z,Qi L,Zhuang J,Wang C,Hong S,Yan L,Wu Y,Cao X,Cao J,Yan J,Zou T,Liu Z,Zhang D,Yan C,Yin P

Fri Sep 17 00:00:00 EDT 2021

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.

Toxicology and applied pharmacology

Wang X,Gong Q,Song C,Fang J,Yang Y,Liang X,Huang X,Liu J

Sat May 01 00:00:00 EDT 2021

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.

eLife

Le Vasseur M,Friedman J,Jost M,Xu J,Yamada J,Kampmann M,Horlbeck MA,Salemi MR,Phinney BS,Weissman JS,Nunnari J

Wed May 26 00:00:00 EDT 2021

Jianpi Qushi Heluo Formula alleviates renal damages in Passive Hemann nephritis in rats by upregulating Parkin-mediated mitochondrial autophagy.

Scientific reports

Wang XH,Lang R,Zeng Q,Liang Y,Chen N,Ma ZZ,Yu RH

Wed Sep 15 00:00:00 EDT 2021

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.

Nature communications

Guo L,Cui C,Wang J,Yuan J,Yang Q,Zhang P,Su W,Bao R,Ran J,Wu C

Thu Oct 01 00:00:00 EDT 2020

Hypoxia induces tumor cell growth and angiogenesis in non-small cell lung carcinoma via the Akt-PDK1-HIF1α-YKL-40 pathway.

Translational cancer research

Miao Y,Wang W,Dong Y,Hu J,Wei K,Yang S,Lai X,Tang H

Wed Apr 01 00:00:00 EDT 2020

Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.

Nature cell biology

Wang Y,Yuan S,Jia X,Ge Y,Ling T,Nie M,Lan X,Chen S,Xu A

Fri Nov 01 00:00:00 EDT 2019

Prohibitin, relocated to the front ends, can control the migration directionality of colorectal cancer cells.

Oncotarget

Ma LL,Shen L,Tong GH,Tang N,Luo Y,Guo LL,Hu CT,Huang YX,Huang G,Jing FY,Liu C,Li ZY,Zhou N,Yan QW,Lei Y,Zhu SJ,Cheng ZQ,Cao GW,Deng YJ,Ding YQ

Fri Sep 29 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: cox iv; COX IV-1; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; cytochrome c oxidase subunit IV; Cytochrome c oxidase subunit IV isoform 1; FLJ23483; MGC72016

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Gene Aliases: COX IV-1; COX4; COX4-1; COX4I1; COXIV; COXIV-1

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UniProt ID: (Human) P13073

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Entrez Gene ID: (Human) 1327

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Function(s)

cytochrome-c oxidase activity protein binding oxidase

Process(es)

generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen response to nutrient hydrogen ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COXIV Monoclonal Antibody (2A7B2)

COXIV Antibody (66110-1-IG) in ICC/IF

Product Details

66110-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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