Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-143081
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-DSQESVDSVTDSQK.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933720
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_004370.1; NP_604391.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein
Gene Aliases: 2310001E10Rik; 3526402H21Rik; AV083133; CREB; CREB-1; CREB1
UniProt ID: (Human) P16220, (Mouse) Q01147
Entrez Gene ID: (Human) 1385, (Mouse) 12912
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor activity
protein binding
enzyme binding
Hsp70 protein binding
histone acetyltransferase binding
cAMP response element binding
identical protein binding
arrestin family protein binding
DNA binding
double-stranded DNA binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
transforming growth factor beta receptor signaling pathway
axonogenesis
lactation
memory
circadian rhythm
regulation of cell size
response to organic substance
negative regulation of transcription by competitive promoter binding
pituitary gland development
cell differentiation
mammary gland development
positive regulation of transforming growth factor beta3 production
secretory granule organization
response to glucagon
positive regulation of multicellular organism growth
response to drug
regulation of circadian rhythm
regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
positive regulation of lipid biosynthetic process
rhythmic process
protein stabilization
lung epithelium development
lung saccule development
Type I pneumocyte differentiation
cellular response to zinc ion
cellular response to growth factor stimulus
response to hypoxia
signal transduction
axon guidance
aging
visual learning
response to activity
viral process
chemotaxis to arachidonic acid
response to nicotine
cellular response to hepatocyte growth factor stimulus
cellular response to platelet-derived growth factor stimulus
response to antidepressant
positive regulation of apoptotic process
regulation of fibroblast proliferation
regulation of glial cell proliferation
cellular response to fatty acid
positive regulation of long-term synaptic potentiation
negative regulation of neuron death
response to L-glutamate
cellular response to nerve growth factor stimulus
cellular response to insulin-like growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support