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Product Details
PA5-21007
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the amino terminus of human CRISP2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153782
Product Specific Information
A suggested positive control is human testis tissue lysate.
PA5-21007 can be used with blocking peptide PEP-1121.
Target Information
The cysteine-rich secretory proteins (CRISP) family is a group of four proteins that are strongly expressed in the male reproductive tract and have been implicated in having roles in male fertility. CRISP2, also known as TPX1, has been implicated in the adhesion between spermatids and Sertoli cells, and with CRISP1, is thought to be involved in sperm-egg fusion. CRISP2 has been shown to regulate the Ca2+ influx through ryanodine receptors (RYR) and may influence the acrosome reaction or sperm motility. CRISP2 has also been shown to bind to the mitogen-activated protein kinase kinase kinase 11 (MAP3K11) and localizes to the developing acrosome, suggesting this CRISP2-MAP3K11 complex may have a role in acrosome development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 36; CRISP-2; CT36; Cysteine-rich secretory protein 2; glyceraldehyde-3-phosphate dehydrogenase-like 5; MGC111136; OTTHUMP00000016589; testicular tissue protein Li 43; testis specific protein 1 (probe H4-1 p3-1); Testis-specific protein TPX-1
Gene Aliases: CRISP-2; CRISP2; CT36; GAPDL5; TPX1; TSP1
UniProt ID: (Human) P16562
Entrez Gene ID: (Human) 7180
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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