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CRP Antibody (600-980) in WB
Western Blot: The recombinant protein of full length human CRP was blotted by Rabbit anti CRP (IN) (Cat#600-980) at 1:500. An immunoreactive band was observed at ~25 kDa. The whole lysate derived from Hela (20 µg/lane) immunoblotted by Rabbit anti – p53 (Cat# ) at 1:500. Observed a major immunoreactive band at molecular weight kDa.
Product Details
600-980
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the N-terminus of human CRP protein (from 32aa-41aa)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: CRP full length recombinant protein
Cellular location: Cytoplasmic.
Target Information
CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c reactive; C-reactive protein; C-reactive protein, petaxin related; CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; pentraxin 1; RP11-419N10.4
Gene Aliases: AI255847; CRP; PTX1
UniProt ID: (Human) P02741, (Mouse) P14847
Entrez Gene ID: (Human) 1401, (Mouse) 12944
acute-phase response
complement activation, classical pathway
positive regulation of gene expression
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
regulation of low-density lipoprotein particle clearance
negative regulation of superoxide anion generation
positive regulation of superoxide anion generation
wound healing
positive regulation of nitric oxide biosynthetic process
negative regulation of vasodilation
protein polymerization
cellular response to calcium ion
positive regulation of dendrite development
regulation of interleukin-8 secretion
inflammatory response
opsonization
defense response to Gram-positive bacterium
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