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Invitrogen
CSF1R Recombinant Rabbit Monoclonal Antibody (PD00-45)
FIGURE: 1 / 2
CSF1R Antibody (MA5-50710) in IHC (P)
Immunohistochemistry of CSF1R in paraffin-embedded human colon carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with CSF1R recombinant monoclonal antibody (Product # MA5-50710) with a dilution of 1:10,000 for 1 hou... View More
Product Details
MA5-50710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PD00-45
Immunogen
Recombinant protein within human CSF1R aa 539-972/972 (Cytoplasmic)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3092985
Product Specific Information
Positive control: Human tonsil tissue, human colon carcinoma tissue.
Predicted band size: 108 kDa
Subcellular Location: Cell membrane.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms
Gene Aliases: C-FMS; CD115; CSF-1R; CSF1R; CSFR; FIM2; FMS; HDLS; M-CSF-R
UniProt ID: (Human) P07333
Entrez Gene ID: (Human) 1436
positive regulation of protein phosphorylation
inflammatory response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
axon guidance
skeletal muscle tissue development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
olfactory bulb development
forebrain neuron differentiation
hemopoiesis
monocyte differentiation
macrophage differentiation
osteoclast differentiation
positive regulation of cell migration
ruffle organization
cellular response to macrophage colony-stimulating factor stimulus
macrophage colony-stimulating factor signaling pathway
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
innate immune response
regulation of bone resorption
cell-cell junction maintenance
positive regulation of osteoclast differentiation
phosphatidylinositol metabolic process
protein autophosphorylation
phosphatidylinositol-mediated signaling
mammary gland duct morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
positive regulation of protein serine/threonine kinase activity
positive regulation of chemokine secretion
positive regulation of cell motility
regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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