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Product Details
H00001487-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2G7
Immunogen
CTBP1 (AAH53320, 1 a.a. approximately 429 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSGVRPPIMN GPLHPRPLVA LLDGRDCTVE MPILKDVATV AFCDAQSTQE IHEKVLNEAV GALMYHTITL TREDLEKFKA LRIIVRIGSG FDNIDIKSAG DLGIAVCNVP AASVEETADS TLCHILNLYR RATWLHQALR EGTRVQSVEQ IREVASGAAR IRGETLGIIG LGRVGQAVAL RAKAFGFNVL FYDPYLSDGV ERALGLQRVS TLQDLLFHSD CVTLHCGLNE HNHHLINDFT VKQMRQGAFL VNTARGGLVD EKALAQALKE GRIRGAALDV HESEPFSFSQ GPLKDAPNLI CTPHAAWYSE QASIEMREEA AREIRRAITG RIPDSLKNCV NKDHLTAATH WASMDPAVVH PELNGAAYRY PPGVVGVAPT GIPAAVEGIV PSAMSLSHGL PPVAHPPHAP SPGQTVKPEA DRDHASDQL
Target Information
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684
Gene Aliases: BARS; CTBP; CTBP1
UniProt ID: (Human) Q13363
Entrez Gene ID: (Human) 1487
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
transcription factor binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein domain specific binding
protein homodimerization activity
NAD binding
repressing transcription factor binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of cell proliferation
viral genome replication
positive regulation of histone deacetylation
negative regulation of histone acetylation
negative regulation of transcription, DNA-templated
white fat cell differentiation
regulation of cell cycle
oxidation-reduction process
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter by histone modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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