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Invitrogen
CTH Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 8
CTH Antibody (PA5-29725) in IHC (P)
CTH Polyclonal Antibody detects CTH protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma tissue. CTH Polyclonal Antibody (Product # PA5-29725) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29725
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 194 and 405 of Human CTH
Conjugate
Form
Liquid
Concentration
1.02 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547199
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, mouse liver, rat liver.
Predicted reactivity: Mouse (84%), Rat (85%), Pig (86%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CGL; CTL target antigen; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471; PRB-RA; Probasin-related antigen
Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3; H
UniProt ID: (Human) P32929, (Rat) P18757, (Mouse) Q8VCN5
Entrez Gene ID: (Human) 1491, (Rat) 24962, (Mouse) 107869
cystathionine gamma-synthase activity
cystathionine gamma-lyase activity
protein binding
calmodulin binding
carbon-sulfur lyase activity
pyridoxal phosphate binding
L-cystine L-cysteine-lyase (deaminating)
homocysteine desulfhydrase activity
L-cysteine desulfhydrase activity
cystathionine beta-lyase activity
catalytic activity
lyase activity
lyase
sulfur amino acid catabolic process
cysteine metabolic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
endoplasmic reticulum unfolded protein response
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein sulfhydration
positive regulation of NF-kappaB transcription factor activity
protein homotetramerization
hydrogen sulfide biosynthetic process
'de novo' L-methionine biosynthetic process
positive regulation of aortic smooth muscle cell differentiation
negative regulation of apoptotic signaling pathway
glutathione metabolic process
negative regulation of cell proliferation
negative regulation of cell growth
negative regulation of apoptotic process
homocysteine metabolic process
cellular amino acid biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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