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Product Details
H00001491-M03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
S51
Immunogen
CTH (AAH15807, 1 a.a. approximately 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGRSDV VMGLVSVNCE SLHNRLRFLQ NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS
Target Information
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGL; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471
Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3
UniProt ID: (Human) P32929, (Mouse) Q8VCN5
Entrez Gene ID: (Human) 1491, (Mouse) 107869
cystathionine gamma-synthase activity
cystathionine gamma-lyase activity
protein binding
calmodulin binding
carbon-sulfur lyase activity
pyridoxal phosphate binding
L-cystine L-cysteine-lyase (deaminating)
homocysteine desulfhydrase activity
L-cysteine desulfhydrase activity
catalytic activity
cystathionine beta-lyase activity
lyase activity
lyase
sulfur amino acid catabolic process
cysteine metabolic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
endoplasmic reticulum unfolded protein response
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein sulfhydration
positive regulation of NF-kappaB transcription factor activity
protein homotetramerization
hydrogen sulfide biosynthetic process
'de novo' L-methionine biosynthetic process
positive regulation of aortic smooth muscle cell differentiation
negative regulation of apoptotic signaling pathway
glutathione metabolic process
negative regulation of cell proliferation
cellular amino acid biosynthetic process
negative regulation of cell growth
negative regulation of apoptotic process
homocysteine metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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