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CTHRC1 Antibody (A305-863A-T) in WB
Detection of human and mouse CTHRC1 by western blot. Samples: Whole cell lysate (50 µg) from UACC-62, Malme-3M, SR, and NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified Rabbit anti-CTHRC1 antibody A305-863A-M (lot A305-863A-M-1) used for WB at 1:1000. Detection: Chemiluminescence with an exposure time of 10 seconds.
Product Details
A305-863A-T
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
between 193 and 243
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Target Information
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagen triple helix repeat-containing protein 1
Gene Aliases: 1110014B07Rik; CTHRC1; UNQ762/PRO1550
UniProt ID: (Human) Q96CG8, (Mouse) Q9D1D6
Entrez Gene ID: (Human) 115908, (Mouse) 68588
cell migration
positive regulation of protein binding
positive regulation of osteoblast proliferation
ossification involved in bone remodeling
positive regulation of osteoblast differentiation
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor stereocilium organization
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
establishment of planar polarity involved in neural tube closure
Performance Guarantee
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