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Invitrogen
CTLA-4 Recombinant Mouse Monoclonal Antibody (13D6)
FIGURE: 1 / 3
CTLA-4 Antibody (MA5-50252) in ICC/IF
Immunocytochemistry analysis of HEPG2 cell with CTLA-4 monoclonal antibody (Product # MA5-50252) at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L).
Product Details
MA5-50252
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
13D6
Immunogen
Recombinant Human CTLA4 protein
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_3093687
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD152; CD152 antigen; CD152 isoform; celiac disease 3; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; ICOS; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Gene Aliases: ALPS5; CD; CD152; CELIAC3; CTLA-4; CTLA4; GRD4; GSE; IDDM12; Ly-56
UniProt ID: (Human) P16410, (Mouse) P09793
Entrez Gene ID: (Human) 1493, (Mouse) 12477
adaptive immune response
immune response
cellular response to DNA damage stimulus
negative regulation of B cell proliferation
T cell costimulation
positive regulation of apoptotic process
negative regulation of regulatory T cell differentiation
B cell receptor signaling pathway
immune system process
negative regulation of T cell proliferation
negative regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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