Invitrogen

CX3CL1 Monoclonal Antibody (4C5)

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

View all (29) CX3CL1 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA1-031

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

4C5

Immunogen

Non-glycosylated, polypeptide chain containing 76 amino acids of chemokine domain expressed in E. coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536715

Target Information

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABCD-3; C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1

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Gene Aliases: A-152E5.2; AB030188; ABCD-3; AI848747; C3Xkine; CX3C; CX3CL1; CXC3; CXC3C; D8Bwg0439e; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1

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UniProt ID: (Human) P78423, (Mouse) O35188

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Entrez Gene ID: (Human) 6376, (Mouse) 20312

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Function(s)
receptor binding integrin binding protein binding chemokine activity CX3C chemokine receptor binding CCR chemokine receptor binding cytokine activity cytokine intercellular signal molecule
Process(es)
response to hypoxia microglial cell activation positive regulation of neuroblast proliferation leukocyte migration involved in inflammatory response monocyte chemotaxis chemotaxis defense response immune response cell adhesion G-protein coupled receptor signaling pathway aging positive regulation of macrophage chemotaxis cytokine-mediated signaling pathway platelet activation neutrophil chemotaxis leukocyte chemotaxis positive regulation of transforming growth factor beta1 production integrin activation positive regulation of GTPase activity positive regulation of angiogenesis negative regulation of vasoconstriction macrophage chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation negative regulation of cytokine secretion positive regulation of inflammatory response leukocyte adhesive activation positive regulation of calcium-independent cell-cell adhesion angiogenesis involved in wound healing inhibitory postsynaptic potential chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cell migration wound healing positive regulation of cell adhesion cell chemotaxis
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