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CXCL11 Antibody (PA5-116353) in WB
Western Blot analysis of CXCL11 using the CXCL11 Polyclonal Antibody (Product # PA5-116353) at a 1:2000 dilution. Lane 1: human liver lysates, Lane 2: human spleen lysates, Lane 3: rat liver lysates. Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution Predicted band size : 10 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-116353
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
recombinant protein of human CXCL11
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900987
Target Information
Interferon-inducible T-cell alpha chemoattractant ( I-TAC), belonging to the CXC chemokine family, is expressed in peripheral blood leukocytes, pancreas and liver, thymus, spleen, lung, small intestine, placenta and prostate. Its molecular weight is 8-11 kD. I-TAC is also known as CXCL-11 and IP-9. The cytokine is involved in regulating calcium release and inducing a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. It is upregulated in patients with AIDS, dementia and in patients with multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-R1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 11; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 11; CXC; CXC motif chemokine; CXCL; H174; I-TAC; Interferon gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; IP-9; MGC102770; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; Small-inducible cytokine B11
Gene Aliases: b-R1; CXCL11; H174; I-TAC; IP-9; IP9; ITAC; SCYB11; SCYB9B
UniProt ID: (Human) O14625
Entrez Gene ID: (Human) 6373, (Rat) 305236
positive regulation of leukocyte chemotaxis
chemotaxis
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
cell-cell signaling
T cell chemotaxis
positive regulation of cAMP metabolic process
response to lipopolysaccharide
regulation of cell proliferation
positive regulation of cAMP-mediated signaling
positive regulation of release of sequestered calcium ion into cytosol
chemokine-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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