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CXCL12 Antibody (MA5-23547) in Flow
Flow cytometry of CXCL12 in MG‚63 human osteosarcoma cell line. Samples were incubated in CXCL12 monoclonal antibody (Product # MA5-23547) or isotype control. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Product Details
MA5-23547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
79018
Immunogen
E. coli-derived recombinant human CXCL12/SDF-1 alpha Lys22-Lys89
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608710
Target Information
CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12; CXC; CXC motif chemokine; CXCL; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; SDF-1a; SDF-1b; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; Thymic lymphoma cell-stimulating factor; TLSF; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1
Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1
UniProt ID: (Human) Q5IT36, (Mouse) P40224
Entrez Gene ID: (Human) 6387, (Mouse) 20315
patterning of blood vessels
ameboidal-type cell migration
neuron migration
positive regulation of endothelial cell proliferation
chemotaxis
immune response
germ cell development
brain development
motor neuron axon guidance
positive regulation of cell proliferation
adult locomotory behavior
germ cell migration
telencephalon cell migration
regulation of cell migration
positive regulation of cell migration
organ regeneration
positive regulation of dopamine secretion
T cell proliferation
positive regulation of neuron differentiation
positive regulation of cell adhesion
positive regulation of axon extension involved in axon guidance
induction of positive chemotaxis
regulation of calcium ion transport
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of monocyte chemotaxis
positive regulation of myoblast fusion
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte apoptotic process
positive regulation of T cell migration
response to hypoxia
cellular calcium ion homeostasis
cell adhesion
signal transduction
G-protein coupled receptor signaling pathway
axon guidance
blood circulation
regulation of actin polymerization or depolymerization
response to radiation
response to heat
response to mechanical stimulus
response to virus
response to peptide hormone
positive chemotaxis
positive regulation of calcium ion import
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