Proteintech

CXCL13/BCA1 Polyclonal Antibody

CXCL13/BCA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CXCL13/BCA1 Antibody (10927-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 10927-1-AP) (CXCL13/BCA1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CXCL13/BCA1 Antibody in Western Blot (WB)

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Product Details

10927-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CXCL13/BCA1 Fusion Protein Ag1358 (1-109 aa encoded by BC012589)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKFISTSLL LMLLVSSLSP VQGVLEVYYT SLRCRCVQES SVFIPRRFID RIQILPRGNG CPRKEIIVWK KNKSIVCVDP QAEWIQRMME VLRKRSSSTL PVPVFKRKIP (1-109 aa encoded by BC012589)

Target Information

CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt’s Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in triple negative breast cancer.

Clinical and experimental medicine

Zhang J,Zhang M,Tian Q,Yang J

Wed Nov 01 00:00:00 EDT 2023

Identification of a novel immune gene panel in tongue squamous cell carcinoma.

American journal of translational research

Sun J,Guo F,Tang Q,Chen G,Peng J,Shen Y,Zhang J,Hu J,Yang C

Sat Jul 16 00:00:00 EDT 2022

MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.

Genomics

Shi Y,He W,Zhong M,Yu M

Thu Jul 01 00:00:00 EDT 2021

Single-Cell RNA-seq Reveals Characteristics of Malignant Cells and Immune Microenvironment in Subcutaneous Panniculitis-Like T-Cell Lymphoma.

Frontiers in oncology

Li Z,Wang H,Dong R,Man J,Sun L,Qian X,Zhu X,Cao P,Yu Y,Le J,Fu Y,Wang P,Jiang W,Shen C,Ma Y,Chen L,Xu Y,Shi J,Zhang H,Qian M,Zhai X

Thu Apr 21 00:00:00 EDT 2022

A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration.

Frontiers in immunology

Werner F,Wagner C,Simon M,Glatz K,Mertz KD,Läubli H,Griss J,Wagner SN

Tue Oct 26 00:00:00 EDT 2021

A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration.

Frontiers in immunology

Werner F,Wagner C,Simon M,Glatz K,Mertz KD,Läubli H,Griss J,Wagner SN

Tue Oct 26 00:00:00 EDT 2021

Defined lifestyle and germline factors predispose Asian populations to gastric cancer.

Science advances

Suzuki A,Katoh H,Komura D,Kakiuchi M,Tagashira A,Yamamoto S,Tatsuno K,Ueda H,Nagae G,Fukuda S,Umeda T,Totoki Y,Abe H,Ushiku T,Matsuura T,Sakai E,Ohshima T,Nomura S,Seto Y,Shibata T,Rino Y,Nakajima A,Fukayama M,Ishikawa S,Aburatani H

Fri May 01 00:00:00 EDT 2020

Immune profiling reveals prognostic genes in high-grade serous ovarian cancer.

Aging

Wu Y,Xia L,Zhao P,Deng Y,Guo Q,Zhu J,Chen X,Ju X,Wu X

Tue Jun 16 00:00:00 EDT 2020

The role of high serum CXCL13 level in Waldenström macroglobulinemia.

Leukemia research

Wu YY,Cai H,Zhao AL,Zhang L,Zhou DB,Cao XX,Li J

Sat Jun 01 00:00:00 EDT 2019

Identification of CXCL13 as a potential biomarker in clear cell renal cell carcinoma via comprehensive bioinformatics analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Xu T,Ruan H,Song Z,Cao Q,Wang K,Bao L,Liu D,Tong J,Yang H,Chen K,Zhang X

Tue Oct 01 00:00:00 EDT 2019

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.

Nature communications

Griss J,Bauer W,Wagner C,Simon M,Chen M,Grabmeier-Pfistershammer K,Maurer-Granofszky M,Roka F,Penz T,Bock C,Zhang G,Herlyn M,Glatz K,Läubli H,Mertz KD,Petzelbauer P,Wiesner T,Hartl M,Pickl WF,Somasundaram R,Steinberger P,Wagner SN

Fri Sep 13 00:00:00 EDT 2019

MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.

Molecular medicine reports

Xu W,Li J,Tian H,Wang R,Feng Y,Tang J,Jia J

Fri Nov 01 00:00:00 EDT 2019

Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Kim MJ,Romero R,Kim CJ,Tarca AL,Chhauy S,LaJeunesse C,Lee DC,Draghici S,Gotsch F,Kusanovic JP,Hassan SS,Kim JS

Sun Mar 15 00:00:00 EDT 2009

Journal of immunology (Baltimore, Md. : 1950)

Kim MJ,Romero R,Kim CJ,Tarca AL,Chhauy S,LaJeunesse C,Lee DC,Draghici S,Gotsch F,Kusanovic JP,Hassan SS,Kim JS

Sun Mar 15 00:00:00 EDT 2009

Journal of immunology (Baltimore, Md. : 1950)

Kim MJ,Romero R,Kim CJ,Tarca AL,Chhauy S,LaJeunesse C,Lee DC,Draghici S,Gotsch F,Kusanovic JP,Hassan SS,Kim JS

Sun Mar 15 00:00:00 EDT 2009

A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Nhan-Chang CL,Romero R,Kusanovic JP,Gotsch F,Edwin SS,Erez O,Mittal P,Kim CJ,Kim MJ,Espinoza J,Friel LA,Vaisbuch E,Than NG,Mazaki-Tovi S,Hassan SS

Sat Nov 01 00:00:00 EDT 2008

A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation.

Nhan-Chang CL,Romero R,Kusanovic JP,Gotsch F,Edwin SS,Erez O,Mittal P,Kim CJ,Kim MJ,Espinoza J,Friel LA,Vaisbuch E,Than NG,Mazaki-Tovi S,Hassan SS

Sat Nov 01 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: Angie; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; BCA-1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 13; CC motif chemokine; CCmotif chemokine; chem; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); CXC; CXC chemokine BLC; CXC motif chemokine; CXC motif chemokine 13; CXCL; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); Small-inducible cytokine B13

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Gene Aliases: ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; CXCL13; SCYB13

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UniProt ID: (Human) O43927

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Entrez Gene ID: (Human) 10563

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Function(s)

chemokine activity heparin binding fibroblast growth factor binding CXCR5 chemokine receptor binding CCR10 chemokine receptor binding protein heterodimerization activity receptor agonist activity CXCR3 chemokine receptor binding chemokine

Process(es)

germinal center formation lymphocyte chemotaxis across high endothelial venule chronic inflammatory response regulation of humoral immune response inflammatory response immune response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling positive regulation of T cell chemotaxis response to lipopolysaccharide positive regulation of integrin activation positive regulation of cell-cell adhesion mediated by integrin B cell chemotaxis endothelial cell chemotaxis to fibroblast growth factor B cell chemotaxis across high endothelial venule regulation of cell proliferation defense response to bacterium regulation of angiogenesis lymph node development chemokine-mediated signaling pathway activation of GTPase activity negative regulation of endothelial cell chemotaxis to fibroblast growth factor

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXCL13/BCA1 Polyclonal Antibody

CXCL13/BCA1 Antibody (10927-1-AP) in IHC (P)

Product Details

10927-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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