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CXCL17 Antibody (MA5-24157) in ICC/IF
Immunocytochemistry analysis of CXCL17 in immersion fixed A549 human lung carcinoma cell line. Samples were incubated in CXCL17 monoclonal antibody (Product # MA5-24157) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red) and counterstained with DAPI(blue). Specific staining was localized to cytoplasm.
Product Details
MA5-24157
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2B
Class
Monoclonal
Type
Antibody
Clone
422208
Immunogen
E. coli-derived recombinant human CXCL17/VCC-1 Leu24-Leu119
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607196
Product Specific Information
In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant mouse CXCL17 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CXCL17 is a chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. In particular, CXCL17 is a mucosal chemokine that attracts dendritic cells and blood monocytes to the lungs. CXCL17 plays a role in angiogenesis and possibly in the development of tumors. Further, CXCL17 acts as an anti-inflammatory in the stomach and may play a role in the innate defense against infections. CXCL17 also activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. 4-Cys CXCL17 seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. Diseases associated with CXCL17 dysfunction include cholera.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 6-Cys CXCL17; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 17; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 17; CXC; CXC motif chemokine; CXCL; Dendritic cell and monocyte chemokine-like protein; DMC; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1
Gene Aliases: CXCL17; Dcip1; DMC; UNQ473; UNQ473/PRO842; VCC-1; VCC1
UniProt ID: (Human) Q6UXB2
Entrez Gene ID: (Human) 284340
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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