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CXCL5 Antibody (MA5-23839) in Neu
Neutralization of CXCL5 in BaF3 mouse pro‚B cell line transfected with human CXCR2. Samples were incubated in CXCL5 monoclonal antibody (Product # MA5-23839). Recombinant Mouse LIX chemoattracts the BaF3 mouse pro‚B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse LIX (0.2 µg/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse LIX Monoclonal ... View More
Product Details
MA5-23839
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2B
Class
Monoclonal
Type
Antibody
Clone
61905
Immunogen
E. coli-derived recombinant mouse LIX Val45-Ala118
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608638
Product Specific Information
In Western blots, no cross-reactivity with recombinant human CXCL1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12/SDF-1 alpha, 12/SDF-1 beta, 13, recombinant mouse CXCL1, 2, 6, 9, 10, 12/SDF-1 alpha, 13, recombinant rat CXCL1, 3/CINC-2 alpha, 3/CINC-2 beta, or recombinant porcine CXCL8 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 5; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; Cytokine LIX; granulocyte chemotactic protein-2; small inducible cytokine B subfamily, member 5; small inducible cytokine subfamily B, member 15; Small-inducible cytokine B5
Gene Aliases: AMCF-II; Cxcl5; ENA-78; GCP-2; LIX; Scyb5; Scyb6
UniProt ID: (Mouse) P50228
Entrez Gene ID: (Mouse) 20311
leukocyte homeostasis
cytokine production
positive regulation of leukocyte chemotaxis
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of neuron projection development
organ regeneration
response to lipopolysaccharide
regulation of chemokine production
regulation of cell proliferation
positive regulation of JAK-STAT cascade
cell chemotaxis
chemokine-mediated signaling pathway
regulation of neutrophil mediated killing of gram-negative bacterium
Performance Guarantee
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