Proteintech

CXCR2 Polyclonal Antibody

CXCR2 Antibody in Immunocytochemistry (ICC/IF)

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CXCR2 Antibody (20634-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using IL8RB antibody 20634-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CXCR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CXCR2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20634-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CXCR2 Fusion Protein Ag14670 (1-57 aa encoded by BC037961)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEDFNMESD SFEDFWKGED LSNYSYSSTL PPFLLDAAPC EPESLEINKY FVVIIYAL (1-57 aa encoded by BC037961)

Target Information

CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.

Journal of extracellular vesicles

Wang X,Xu F,Kou H,Zheng Y,Yang J,Xu Z,Fang Y,Sun W,Zhu S,Jiang Q,Wei X,Xu Y

Sat Jul 01 00:00:00 EDT 2023

Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.

Journal of extracellular vesicles

Wang X,Xu F,Kou H,Zheng Y,Yang J,Xu Z,Fang Y,Sun W,Zhu S,Jiang Q,Wei X,Xu Y

Sat Jul 01 00:00:00 EDT 2023

Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.

Cellular and molecular life sciences : CMLS

Ye S,Huang H,Xiao Y,Han X,Shi F,Luo W,Chen J,Ye Y,Zhao X,Huang W,Wang Y,Lai D,Liang G,Fu G

Tue Jun 20 00:00:00 EDT 2023

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.

Journal of nanobiotechnology

Yang N,Li M,Wu L,Song Y,Yu S,Wan Y,Cheng W,Yang B,Mou X,Yu H,Zheng J,Li X,Yu X

Fri Jan 13 00:00:00 EST 2023

DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.

International immunopharmacology

Seto-Tetsuo F,Arioka M,Miura K,Inoue T,Igawa K,Tomooka K,Sasaguri T

Sat Apr 01 00:00:00 EDT 2023

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.

Cell reports

Luo S,Liao C,Zhang L,Ling C,Zhang X,Xie P,Su G,Chen Z,Zhang L,Lai T,Tang J

Tue Mar 28 00:00:00 EDT 2023

SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.

Medical oncology (Northwood, London, England)

Tang L,Peng L,Liu H,Xiao T,Gu W,Yang H,Wang H,Chen P

Thu Sep 29 00:00:00 EDT 2022

Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.

Journal of dermatological science

Yao YZ,Liao ZK,Jiang S,Dong BQ,Luo LF,Miao F,Lei TC

Tue Nov 01 00:00:00 EDT 2022

IL-8 exacerbates CCl₄-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.

Molecular immunology

Ma Y,Bao Y,Wu L,Ke Y,Tan L,Ren H,Song J,Zhang Q,Jin Y

Thu Dec 01 00:00:00 EST 2022

The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response.

Frontiers in physiology

Tang H,Yang M,Liu Y,Liu H,Sun L,Song P

Tue Jan 04 00:00:00 EST 2022

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.

International journal of molecular sciences

Ge S,Yang W,Chen H,Yuan Q,Liu S,Zhao Y,Zhang J

Wed Nov 17 00:00:00 EST 2021

IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.

Cytokine

Wang Z,Li B,Jiang H,Ma Y,Bao Y,Zhu X,Xia H,Jin Y

Mon Feb 01 00:00:00 EST 2021

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.

Frontiers in molecular biosciences

Xue Y,Zhou Y,Bao W,Fu Q,Hao H,Han L,Zhang X,Tian X,Zhang M

Fri Nov 12 00:00:00 EST 2021

CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.

Frontiers in immunology

Zhang S,Ding J,Wang J,Yin T,Zhang Y,Yang J

Mon Dec 20 00:00:00 EST 2021

XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.

Cell communication and signaling : CCS

Zheng Y,Wang N,Wang S,Yang B,Situ H,Zhong L,Lin Y,Wang Z

Thu Mar 26 00:00:00 EDT 2020

Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.

JCI insight

Dominguez C,McCampbell KK,David JM,Palena C

Thu Nov 02 00:00:00 EDT 2017

Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.

JCI insight

Dominguez C,McCampbell KK,David JM,Palena C

Thu Nov 02 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B

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Gene Aliases: CD182; CDw128b; CMKAR2; CXCR2; IL8R2; IL8RA; IL8RB

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UniProt ID: (Human) P25025

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Entrez Gene ID: (Human) 3579

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Function(s)

signal transducer activity interleukin-8 receptor activity protein binding C-X-C chemokine receptor activity interleukin-8 binding

Process(es)

dendritic cell chemotaxis chemotaxis inflammatory response cellular defense response signal transduction cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cell proliferation neutrophil chemotaxis receptor internalization interleukin-8-mediated signaling pathway neutrophil activation chemokine-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXCR2 Polyclonal Antibody

CXCR2 Antibody (20634-1-AP) in ICC/IF

Product Details

20634-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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