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Invitrogen
CXCR2 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 2
CXCR2 Antibody (PA5-83213)
Relative expression in different tissues in IHC: Detection of differential expression levels of CXCR2 demonstrates antibody specificity. Immunohistochemical analysis of CXCR2 using anti-CXCR2 Polyclonal Antibody (Product # PA5-83213), shows significant staining of CXCR2 in spleen and shows minimal or weak staining in cerebral cortex tissues. The relative expression levels of CXCR2 within each tissue is show... View More
Product Details
PA5-83213
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CXCR2. Recombinant protein control fragment (Product #RP-102608).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790369
Product Specific Information
Immunogen sequence: DFNMESDSFE DFWKGEDLSN YSYSSTLPPF LLDAAPCEPE SLEINK
Target Information
CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Gene Aliases: CD182; CDw128b; CMKAR2; CXCR2; IL8R2; IL8RA; IL8RB
UniProt ID: (Human) P25025
Entrez Gene ID: (Human) 3579
dendritic cell chemotaxis
chemotaxis
inflammatory response
cellular defense response
signal transduction
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
neutrophil chemotaxis
receptor internalization
interleukin-8-mediated signaling pathway
neutrophil activation
chemokine-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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