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CYP17A1 Antibody (PA5-79124) in IHC (P)
Immunohistochemistry analysis of CYP17A1 on paraffin-embedded mouse testis tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CYP17A1 polyclonal antibody (Product# PA5-79124) with a dilution of 2 µg/mL (overnight at 4°C), followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Develop... View More
Product Details
PA5-79124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse Cyp17a1 recombinant protein (Position: Q80-R363).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2746240
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-alpha-hydroxyprogesterone aldolase; 17a-hydroxylase; CYPXVII; Cytochrome P450 17A1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; Cytochrome P450-C17; Cytochrome P450c17; HGNC:2593; P450-C17; P45017alpha; P450c17; steroid 17-alpha hydroxylase; Steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-monooxygenase
Gene Aliases: Cyp17; Cyp17a1; p450c17
UniProt ID: (Mouse) P27786, (Rat) P11715
Entrez Gene ID: (Mouse) 13074, (Rat) 25146
steroid biosynthetic process
glucocorticoid biosynthetic process
steroid metabolic process
hormone biosynthetic process
progesterone metabolic process
oxidation-reduction process
positive regulation of steroid hormone biosynthetic process
organic acid metabolic process
androgen biosynthetic process
male gonad development
response to herbicide
response to toxic substance
response to organic substance
response to acetate
response to ionizing radiation
response to organic cyclic compound
response to insecticide
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
hippocampus development
adrenal gland development
ovulation
response to nutrient levels
response to retinoic acid
Leydig cell differentiation
response to cytokine
response to gonadotropin
response to drug
response to steroid hormone
response to cAMP
response to methylmercury
response to fungicide
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to gonadotropin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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