Proteintech

CYP24A1 Polyclonal Antibody

CYP24A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CYP24A1 Antibody (21582-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human kidney using 21582-1-AP (CYP24A1 antibody) at dilution of 1:50 (under 40x lens).

CYP24A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21582-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50

Immunoprecipitation (IP)

1:300

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYP24A1 Fusion Protein Ag16134

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

400 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway.

Current medical science

Chen XQ,Mao JY,Wang CS,Li WB,Han TT,Lv K,Li JN

Sat Oct 01 00:00:00 EDT 2022

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.

Cancer communications (London, England)

He L,Li H,Pan C,Hua Y,Peng J,Zhou Z,Zhao Y,Lin M

Sun Aug 01 00:00:00 EDT 2021

1,25(OH)₂ vitamin D₃ stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine.

The Journal of physiology

Hernando N,Pastor-Arroyo EM,Marks J,Schnitzbauer U,Knöpfel T,Bürki M,Bettoni C,Wagner CA

Mon Feb 01 00:00:00 EST 2021

Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo.

American journal of physiology. Renal physiology

Küng CJ,Haykir B,Schnitzbauer U,Egli-Spichtig D,Hernando N,Wagner CA

Wed Dec 01 00:00:00 EST 2021

The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma.

Translational cancer research

Gao W,Wang TF,Yi W,Tong WM

Sat Aug 01 00:00:00 EDT 2020

The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma.

Translational cancer research

Gao W,Wang TF,Yi W,Tong WM

Sat Aug 01 00:00:00 EDT 2020

Intestinal epithelial ablation of Pit-2/Slc20a2 in mice leads to sustained elevation of vitamin D₃ upon dietary restriction of phosphate.

Acta physiologica (Oxford, England)

Pastor-Arroyo EM,Knöpfel T,Imenez Silva PH,Schnitzbauer U,Poncet N,Biber J,Wagner CA,Hernando N

Thu Oct 01 00:00:00 EDT 2020

Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Debruin DA,Timpani CA,Lalunio H,Rybalka E,Goodman CA,Hayes A

Mon Jun 01 00:00:00 EDT 2020

MAPK inhibition and growth hormone: a promising therapy in XLH.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Fuente R,Gil-Peña H,Claramunt-Taberner D,Hernández-Frías O,Fernández-Iglesias Á,Alonso-Durán L,Rodríguez-Rubio E,Hermida-Prado F,Anes-González G,Rubio-Aliaga I,Wagner C,Santos F

Mon Jul 01 00:00:00 EDT 2019

Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice.

Scientific reports

Daryadel A,Natale L,Seebeck P,Bettoni C,Schnitzbauer U,Gassmann M,Wagner CA

Fri Oct 18 00:00:00 EDT 2019

Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3.

PloS one

Kägi L,Bettoni C,Pastor-Arroyo EM,Schnitzbauer U,Hernando N,Wagner CA

Fri Jul 27 00:00:00 EDT 2018

The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction.

Scientific reports

Knöpfel T,Pastor-Arroyo EM,Schnitzbauer U,Kratschmar DV,Odermatt A,Pellegrini G,Hernando N,Wagner CA

Fri Sep 08 00:00:00 EDT 2017

TAZ regulates cell proliferation and sensitivity to vitamin D3 in intrahepatic cholangiocarcinoma.

Cancer letters

Xiao H,Tong R,Yang B,Lv Z,Du C,Peng C,Ding C,Cheng S,Zhou L,Xie H,Wu J,Zheng S

Fri Oct 28 00:00:00 EDT 2016

TAZ regulates cell proliferation and sensitivity to vitamin D3 in intrahepatic cholangiocarcinoma.

Cancer letters

Xiao H,Tong R,Yang B,Lv Z,Du C,Peng C,Ding C,Cheng S,Zhou L,Xie H,Wu J,Zheng S

Fri Oct 28 00:00:00 EDT 2016

Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.

The Journal of steroid biochemistry and molecular biology

Shintani T,Rosli SNZ,Takatsu F,Choon YF,Hayashido Y,Toratani S,Usui E,Okamoto T

Tue Nov 01 00:00:00 EDT 2016

Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.

The Journal of steroid biochemistry and molecular biology

Shintani T,Rosli SNZ,Takatsu F,Choon YF,Hayashido Y,Toratani S,Usui E,Okamoto T

Tue Nov 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: 1,25-@dihydroxyvitamin D3 24-hydroxylase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; 24R-Ohase; 25-hydroxyvitamin D-24-hydroxylase; 25-hydroxyvitamin D3 24-hydroxylase; Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase); Cytochrome P450 24A1; cytochrome P450, 24; cytochrome P450, 24a1; cytochrome P450, family 24, subfamily A, polypeptide 1; cytochrome P450, subfamily 24; cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; exo-mitochondrial protein; MGC126273; MGC126274; P450-CC24; vitamin D 24-hydroxylase; vitamin D(3) 24-hydroxylase

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Gene Aliases: 24-OHase; 25-hydroxyvitaminD324-hydroxylase; CP24; Cyp-24; CYP24; CYP24A1; HCAI; HCINF1; P450-CC24; VITD12

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UniProt ID: (Human) Q07973, (Mouse) Q64441, (Rat) Q09128

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Entrez Gene ID: (Human) 1591, (Mouse) 13081, (Rat) 25279

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Function(s)

iron ion binding 25-hydroxycholecalciferol-24-hydroxylase activity oxidoreductase activity heme binding 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding oxygenase

Process(es)

osteoblast differentiation vitamin metabolic process response to vitamin D vitamin D metabolic process vitamin D catabolic process oxidation-reduction process vitamin D receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CYP24A1 Polyclonal Antibody

CYP24A1 Antibody (21582-1-AP) in IHC (P)

Product Details

21582-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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