Proteintech

CYP2C8 Polyclonal Antibody

CYP2C8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CYP2C8 Antibody (16546-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 16546-1-AP) (CYP2C8/9/18/19 antibody) at dilution of 1:600 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

16546-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYP2C8 Fusion Protein Ag9898 (142-490 aa encoded by BC020596)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV (142-490 aa encoded by BC020596)

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Xenobiotica; the fate of foreign compounds in biological systems

Li SC,Zhang M,Wang B,Li XT,Liang G

Wed Mar 01 00:00:00 EST 2023

Differentiation of umbilical cord mesenchymal stem cells into hepatocytes with CYP450 metabolic enzyme activity induced by a liver injury microenvironment.

Biochemical and biophysical research communications

Xue G,Zhang J,Wu L,Sun S,Wu H,Hou Y,Wang J

Sun Mar 05 00:00:00 EST 2023

Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.

Frontiers in oncology

Ye T,Lin L,Cao L,Huang W,Wei S,Shan Y,Zhang Z

Sat Jul 16 00:00:00 EDT 2022

3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis.

Cell chemical biology

Shao C,Liu Y,Chen Z,Qin Y,Wang X,Wang X,Yan C,Zhu HL,Zhao J,Qian Y

Thu Jan 20 00:00:00 EST 2022

A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma.

Bioengineered

Shen H,Wu H,Sun F,Qi J,Zhu Q

Wed Dec 01 00:00:00 EST 2021

Prognostic Value and Correlation With Tumor Immune Infiltration of a Novel Metabolism-Related Gene Signature in Pancreatic Cancer.

Frontiers in oncology

Chen H,Zu F,Zeng T,Chen Z,Wei J,Liu P,Li Z,Zhou L,Wang H,Tan H,Tan X

Sun May 01 00:00:00 EDT 2022

Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology.

Frontiers in pharmacology

Chen L,Zhao X,Wei S,Ma X,Liu H,Li J,Jing M,Wang M,Zhao Y

Fri Sep 17 00:00:00 EDT 2021

Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.

Pharmaceutics

Wen C,Hu H,Zhang W,Liu X,Jiang X,Wang L

Fri Sep 17 00:00:00 EDT 2021

Comparative Analysis of Immunohistochemical Staining Intensity Determined by Light Microscopy, ImageJ and QuPath in Placental Hofbauer Cells.

Acta histochemica et cytochemica

Cizkova K,Foltynkova T,Gachechiladze M,Tauber Z

Thu Feb 25 00:00:00 EST 2021

Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells.

Xenobiotica; the fate of foreign compounds in biological systems

Chen M,Zhou C,Zhang T,Wu B

Tue Sep 01 00:00:00 EDT 2020

Time-dependent expression pattern of cytochrome P450 epoxygenases and soluble epoxide hydrolase in normal human placenta.

Acta histochemica

Cizkova K,Tauber Z

Wed Aug 01 00:00:00 EDT 2018

Time-dependent expression pattern of cytochrome P450 epoxygenases and soluble epoxide hydrolase in normal human placenta.

Acta histochemica

Cizkova K,Tauber Z

Wed Aug 01 00:00:00 EDT 2018

Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.

Oncotarget

Zhang D,Lou J,Zhang X,Zhang L,Wang F,Xu D,Niu N,Wang Y,Wu Y,Cui W

Tue Feb 28 00:00:00 EST 2017

Time-dependent expression of cytochrome p450 epoxygenases during human prenatal development.

Organogenesis

Cizkova K,Konieczna A,Erdosova B,Ehrmann J

Wed Jan 01 00:00:00 EST 2014

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.

BMC cancer

Wei X,Zhang D,Dou X,Niu N,Huang W,Bai J,Zhang G

Tue Nov 18 00:00:00 EST 2014

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.

BMC cancer

Wei X,Zhang D,Dou X,Niu N,Huang W,Bai J,Zhang G

Tue Nov 18 00:00:00 EST 2014

Bioinformatics

Protein Aliases: CYPIIC8; Cytochrome P450 2C8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450 form 1; P450 IIC2; P450 MP-12/MP-20; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase

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Gene Aliases: CPC8; CYP2C8; CYPIIC8; MP-12/MP-20

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UniProt ID: (Human) P10632

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Entrez Gene ID: (Human) 1558

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Function(s)

monooxygenase activity iron ion binding arachidonic acid epoxygenase activity steroid hydroxylase activity oxygen binding heme binding caffeine oxidase activity aromatase activity oxidoreductase oxygenase metabolite interconversion enzyme

Process(es)

organic acid metabolic process xenobiotic metabolic process drug metabolic process epoxygenase P450 pathway exogenous drug catabolic process oxidation-reduction process oxidative demethylation omega-hydroxylase P450 pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CYP2C8 Polyclonal Antibody

CYP2C8 Antibody (16546-1-AP) in IHC (P)

Product Details

16546-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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