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FIGURE: 1 / 1
CYP2D6 Antibody (PA5-86925) in WB
Western blot analysis of CYP2D6 in Lane 1: brain tissue lysate of mouse (40 µg), Lane 2: brain tissue lysate of rat (40 µg), Lane 3: MCF-7 whole cell lysate (40 µg), Lane 4: HepG2 whole cell lysate (40 µg). Sample was incubated with CYP2D6 polyclonal antibody (Product # PA5-86925) using a 1:500 dilution.
Product Details
PA5-86925
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human CYP2D6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803683
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Cytochrome p450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cholesterol 25-hydroxylase; CYPIID18; CYPIID3; CYPIID4; CYPIID6; Cytochrome P450 2D-29; Cytochrome P450 2D-35; Cytochrome P450 2D18; Cytochrome P450 2D3; Cytochrome P450 2D4; Cytochrome P450 2D6; cytochrome P450, family 2, subfamily d, polypeptide 13; cytochrome P450, family 2, subfamily d, polypeptide 22; cytochrome P450, family 2, subfamily d, polypeptide 4; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily 2D, polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID, polypeptide 6; Cytochrome P450, subfamily IID3; Cytochrome P450, subfamily IID4; Cytochrome P450-CMF3; Cytochrome P450-DB1; Cytochrome P450-DB3; Cytochrome P450-DB4; Debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; P450 2D-29/2D-35; P450-CMF3; P450-DB3; P450-DB4; xenobiotic monooxygenase
Gene Aliases: CPD6; CYP2D; Cyp2d-18; Cyp2d-3; Cyp2d-4; Cyp2d13; Cyp2d18; Cyp2d22; Cyp2d3; Cyp2d4; Cyp2d4v1; Cyp2d4v2; CYP2D6; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
UniProt ID: (Human) P10635, (Rat) P12938, (Rat) Q64680
Entrez Gene ID: (Human) 1565, (Rat) 24303, (Rat) 171522
monooxygenase activity
iron ion binding
drug binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
aromatase activity
steroid 21-monooxygenase activity
arachidonic acid monooxygenase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
xenobiotic metabolic process
steroid metabolic process
coumarin metabolic process
alkaloid metabolic process
alkaloid catabolic process
monoterpenoid metabolic process
drug metabolic process
arachidonic acid metabolic process
isoquinoline alkaloid metabolic process
drug catabolic process
heterocycle metabolic process
negative regulation of binding
oxidation-reduction process
oxidative demethylation
negative regulation of cellular organofluorine metabolic process
liver development
exogenous drug catabolic process
female pregnancy
response to organic substance
dopamine biosynthetic process
dopamine metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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