Product References
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.
Xenobiotica; the fate of foreign compounds in biological systems
Li SC,Zhang M,Wang B,Li XT,Liang G
Wed Mar 01 00:00:00 EST 2023
Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.
iScience
Chen Y,Cui T,Xiao S,Li T,Zhong Y,Tang K,Guo J,Huang S,Chen J,Li J,Wang Q,Huang J,Pan H,Gao Y
Fri Apr 21 00:00:00 EDT 2023
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
Nature communications
Fan S,Yan Y,Xia Y,Zhou Z,Luo L,Zhu M,Han Y,Yao D,Zhang L,Fang M,Peng L,Yu J,Liu Y,Gao X,Guan H,Li H,Wang C,Wu X,Zhu H,Cao Y,Huang C
Thu Jun 08 00:00:00 EDT 2023
Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem.
Microsystems & nanoengineering
Li S,Li C,Khan MI,Liu J,Shi Z,Gao D,Qiu B,Ding W
Thu Sep 28 00:00:00 EDT 2023
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
Xenobiotica; the fate of foreign compounds in biological systems
Uehara S,Murayama N,Higuchi Y,Yoneda N,Yamazaki H,Suemizu H
Tue Mar 01 00:00:00 EST 2022
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Cells
Qin M,Xin Y,Bian Y,Yang X,Xi T,Xiong J
Thu Jan 13 00:00:00 EST 2022
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
BMC medicine
Zhan Y,Zhang Z,Liu Y,Fang Y,Xie Y,Zheng Y,Li G,Liang L,Ding Y
Wed Oct 19 00:00:00 EDT 2022
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
British journal of pharmacology
Jiang LP,Ji JZ,Ge PX,Zhu T,Mi QY,Tai T,Li YF,Xie HG
Sat Jan 01 00:00:00 EST 2022
Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes.
Molecules (Basel, Switzerland)
Su S,Wu H,Zhou J,Yuan G,Wang H,Feng J
Thu Jul 14 00:00:00 EDT 2022
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease.
Journal of experimental & clinical cancer research : CR
Cigliano A,Zhang S,Ribback S,Steinmann S,Sini M,Ament CE,Utpatel K,Song X,Wang J,Pilo MG,Berger F,Wang H,Tao J,Li X,Pes GM,Mancarella S,Giannelli G,Dombrowski F,Evert M,Calvisi DF,Chen X,Evert K
Fri Jun 03 00:00:00 EDT 2022
Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering.
Frontiers in bioengineering and biotechnology
Guo L,Zhu Z,Gao C,Chen K,Lu S,Yan H,Liu W,Wang M,Ding Y,Huang L,Wang X
Sat Jul 16 00:00:00 EDT 2022
The polyol pathway is an evolutionarily conserved system for sensing glucose uptake.
PLoS biology
Sano H,Nakamura A,Yamane M,Niwa H,Nishimura T,Araki K,Takemoto K,Ishiguro KI,Aoki H,Kato Y,Kojima M
Wed Jun 01 00:00:00 EDT 2022
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhang L,Yan J,Liu J,Meng C,Liu F,Xia C
Fri Jul 01 00:00:00 EDT 2022
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
iScience
Zeidler JD,Chini CCS,Kanamori KS,Kashyap S,Espindola-Netto JM,Thompson K,Warner G,Cabral FS,Peclat TR,Gomez LS,Lopez SA,Wandersee MK,Schoon RA,Reid K,Menzies K,Beckedorff F,Reid JM,Brachs S,Meyer RG,Meyer-Ficca ML,Chini EN
Fri Nov 18 00:00:00 EST 2022
Network Analysis of the Herb-Drug Interactions of Citrus Herbs Inspired by the "Grapefruit Juice Effect".
ACS omega
Lü J,Zhang D,Zhang X,Sa R,Wang X,Wu H,Lin Z,Zhang B
Tue Oct 11 00:00:00 EDT 2022
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
Epilepsy research
Wang J,Fu J,Sun W,Yin X,Lv K,Zhang J
Sat Oct 01 00:00:00 EDT 2022
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug.
Journal of advanced research
Guo J,Xu Y,Chen LJ,Zhang SX,Liou YL,Chen XP,Tan ZR,Zhou HH,Zhang W,Chen Y
Fri Jul 01 00:00:00 EDT 2022
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy.
Frontiers in bioengineering and biotechnology
Liu WM,Zhou X,Chen CY,Lv DD,Huang WJ,Peng Y,Wu HP,Chen Y,Tang D,Guo LN,Wang XL,Zhang HD,Liu XH,Yang LQ,Yu WF,Yan HX
Sat Dec 04 00:00:00 EST 2021
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy.
Frontiers in bioengineering and biotechnology
Liu WM,Zhou X,Chen CY,Lv DD,Huang WJ,Peng Y,Wu HP,Chen Y,Tang D,Guo LN,Wang XL,Zhang HD,Liu XH,Yang LQ,Yu WF,Yan HX
Sat Dec 04 00:00:00 EST 2021
Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply.
Acta biomaterialia
Du K,Li S,Li C,Li P,Miao C,Luo T,Qiu B,Ding W
Fri Oct 15 00:00:00 EDT 2021
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Life sciences
Ge PX,Jiang LP,Tai T,Zhu T,Ji JZ,Li YF,Mi QY,Xie HG
Sun Aug 15 00:00:00 EDT 2021
Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor.
Annals of translational medicine
Qiao EQ,Yang HJ,Yu XF,Gong LJ,Zhang XP,Chen DB
Wed Sep 01 00:00:00 EDT 2021
Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor.
Annals of translational medicine
Qiao EQ,Yang HJ,Yu XF,Gong LJ,Zhang XP,Chen DB
Wed Sep 01 00:00:00 EDT 2021
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Xenobiotica; the fate of foreign compounds in biological systems
Li H,Wang YG,Ma ZC,Yun-Hang G,Ling S,Teng-Fei C,Guang-Ping Z,Gao Y
Thu Jul 01 00:00:00 EDT 2021
Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.
Pharmaceutics
Wen C,Hu H,Zhang W,Liu X,Jiang X,Wang L
Fri Sep 17 00:00:00 EDT 2021
Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro.
Archives of toxicology
Chen Y,Tang D,Wu H,Wu Y,Yuan T,Zhang H,Jiao Y,Yu W,Yan H
Thu Jul 01 00:00:00 EDT 2021
Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study.
Basic & clinical pharmacology & toxicology
Li H,Tang Y,Wei W,Yin C,Tang F
Sat May 01 00:00:00 EDT 2021
The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Hu N,Liu X,Mu Q,Yu M,Wang H,Jiang Y,Chen R,Wang L
Thu Jul 01 00:00:00 EDT 2021
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Molecular and cellular endocrinology
Watanabe LM,Hashimoto AC,Torres DJ,Alfulaij N,Peres R,Sultana R,Maunakea AK,Berry MJ,Seale LA
Sun Aug 01 00:00:00 EDT 2021
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice.
Xenobiotica; the fate of foreign compounds in biological systems
Guo L,Zhang L,Xu H,Yu P,Wang Z,Lu D,Chen M,Wu B
Wed Sep 01 00:00:00 EDT 2021
CYP3A4 and microRNA-122 are involved in the apoptosis of HepG2 cells induced by ILs 1-decyl-3-methylimidazolium bromide.
Journal of biochemical and molecular toxicology
Li AL,Gao SS,Guo ML,Jing CQ
Wed Jan 01 00:00:00 EST 2020
Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Die Pharmazie
Yu C,Pan L,Wang G,Cai Z,Zhou Y,Zheng X,Chen C,Zhang X
Fri May 01 00:00:00 EDT 2020
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice.
Biopharmaceutics & drug disposition
Kim Y,Jo JJ,Cho P,Shrestha R,Kim KM,Ki SH,Song KS,Liu KH,Song IS,Kim JH,Lee JM,Lee S
Wed Jul 01 00:00:00 EDT 2020
Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors.
Planta medica
Zhang X,Meng R,Wang H,Xing J
Sat Aug 01 00:00:00 EDT 2020
Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
Biochemical pharmacology
Hu Q,Yao N,Wu J,Liu M,Liu F,Zhang H,Xiong Y,Xia C
Tue Jan 01 00:00:00 EST 2019
Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
Biochemical pharmacology
Hu Q,Yao N,Wu J,Liu M,Liu F,Zhang H,Xiong Y,Xia C
Tue Jan 01 00:00:00 EST 2019
Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening.
Theranostics
Wang Z,Li W,Jing H,Ding M,Fu G,Yuan T,Huang W,Dai M,Tang D,Zeng M,Chen Y,Zhang H,Zhu X,Peng Y,Li Q,Yu WF,Yan HX,Zhai B
Fri Oct 23 00:00:00 EDT 2020
Integrated Metabolomics and Network Pharmacology Strategy-Driven Active Traditional Chinese Medicine Ingredients Discovery for the Alleviation of Cisplatin Nephrotoxicity.
Chemical research in toxicology
Xu L,Zhang Y,Zhang P,Dai X,Gao Y,Lv Y,Qin S,Xu F
Mon Dec 16 00:00:00 EST 2019
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
Regenerative therapy
Minami T,Ishii T,Yasuchika K,Fukumitsu K,Ogiso S,Miyauchi Y,Kojima H,Kawai T,Yamaoka R,Oshima Y,Kawamoto H,Kotaka M,Yasuda K,Osafune K,Uemoto S
Sat Jun 01 00:00:00 EDT 2019
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Cell death & disease
Wang C,Xu W,Zhang Y,Huang D,Huang K
Thu Jul 26 00:00:00 EDT 2018
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Cell death & disease
Wang C,Xu W,Zhang Y,Huang D,Huang K
Thu Jul 26 00:00:00 EDT 2018
The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte.
Biochimica et biophysica acta. Molecular basis of disease
Li N,Kong M,Zeng S,Xu Z,Li M,Hong W,Chu X,Sun X,Zhu M,Xu Y
Mon Oct 01 00:00:00 EDT 2018
Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.
British journal of pharmacology
Luo W,Xin Y,Zhao X,Zhang F,Liu C,Fan H,Xi T,Xiong J
Sat Apr 01 00:00:00 EDT 2017
Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.
British journal of pharmacology
Luo W,Xin Y,Zhao X,Zhang F,Liu C,Fan H,Xi T,Xiong J
Sat Apr 01 00:00:00 EDT 2017
Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.
Toxicological sciences : an official journal of the Society of Toxicology
Sriwattanapong K,Slocum SL,Chawanthayatham S,Fedeles BI,Egner PA,Groopman JD,Satayavivad J,Croy RG,Essigmann JM
Wed Nov 01 00:00:00 EDT 2017
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
Oncotarget
He L,Li H,Huang N,Zhou X,Tian J,Li T,Wu J,Tian Y,Yin Y,Yao K
Tue Nov 28 00:00:00 EST 2017
Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening.
Hepatology (Baltimore, Md.)
Lv L,Han Q,Chu Y,Zhang M,Sun L,Wei W,Jin C,Li W
Thu Jan 01 00:00:00 EST 2015
Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening.
Hepatology (Baltimore, Md.)
Lv L,Han Q,Chu Y,Zhang M,Sun L,Wei W,Jin C,Li W
Thu Jan 01 00:00:00 EST 2015
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions.
Xenobiotica; the fate of foreign compounds in biological systems
Wang YY,Yang J,Liu H,Lin FQ,Shi JS,Zhang F
Wed Apr 01 00:00:00 EDT 2015
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions.
Xenobiotica; the fate of foreign compounds in biological systems
Wang YY,Yang J,Liu H,Lin FQ,Shi JS,Zhang F
Wed Apr 01 00:00:00 EDT 2015
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Toxins
Zhang B,Liu Y,Li X
Mon Mar 30 00:00:00 EDT 2015
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Toxins
Zhang B,Liu Y,Li X
Mon Mar 30 00:00:00 EDT 2015
Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.
Journal of virological methods
Zhou M,Huang Y,Cheng Z,Zhao F,Li J,Zhi X,Tian X,Sun W,Hu K
Wed Oct 01 00:00:00 EDT 2014
Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.
Journal of virological methods
Zhou M,Huang Y,Cheng Z,Zhao F,Li J,Zhi X,Tian X,Sun W,Hu K
Wed Oct 01 00:00:00 EDT 2014
Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells.
Journal of virological methods
Zhou M,Zhao F,Li J,Cheng Z,Tian X,Zhi X,Huang Y,Hu K
Wed Jan 01 00:00:00 EST 2014
Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells.
Journal of virological methods
Zhou M,Zhao F,Li J,Cheng Z,Tian X,Zhi X,Huang Y,Hu K
Wed Jan 01 00:00:00 EST 2014
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
PloS one
Sliva D,Loganathan J,Jiang J,Jedinak A,Lamb JG,Terry C,Baldridge LA,Adamec J,Sandusky GE,Dudhgaonkar S
Thu May 09 00:00:00 EDT 2013
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
PloS one
Sliva D,Loganathan J,Jiang J,Jedinak A,Lamb JG,Terry C,Baldridge LA,Adamec J,Sandusky GE,Dudhgaonkar S
Thu May 09 00:00:00 EDT 2013
