Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-81535
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Mouse PPP3CA
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2788739
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse Calcineurin A/PPP3CA.
Target Information
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Calcineurin A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; Protein phosphatase 3 catalytic subunit alpha; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Aliases: 2900074D19Rik; Caln; Calna; CN; CnA; Ppp3ca
UniProt ID: (Mouse) P63328
Entrez Gene ID: (Mouse) 19055
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
protein binding
calmodulin binding
drug binding
hydrolase activity
enzyme binding
calmodulin-dependent protein phosphatase activity
metal ion binding
protein heterodimerization activity
protein dimerization activity
protein phosphatase
G1/S transition of mitotic cell cycle
protein dephosphorylation
protein import into nucleus
calcium ion transport
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcium-mediated signaling
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support