Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: NISNHQLTQ GRLGHKPMVS AFSCLAVQES HWTKTIPNHK EQEWDPQKTE KYAGIFHFRF WHFGEWTEVV IDDLLPTING DLVFSFSTSM NEFWNALLEK AYAKLLGCYE ALDGLTITDI IVDFTGTLAE TVDMQKGRYT ELVEEKYKLF GELYKTFTKG GLICCSIESP NQEEQEVETD WGLLKGHTYT MTDIRKIRLG ERLVEVFSAE KVYMVRLRNP LGRQEWSGPW SEISEEWQQL TASDRKNLGL VMSDDGEFWM SLEDFCRNFH KLNVCRNVNN PIFGRKELES VLGCW (67-360 aa encoded by B C000730)
Calpain-6, also known as calpamodulin or calpain-X, is an intracellular, calcium-dependent cysteine protease. Calpain-6 has a much more tissue-specific expression in adults than the ubiquitous calpain-1 and calpain-2, and has thus far been found primarily in the placenta, although it is expressed embryonically in a number of tissues. The classical calpain family members consist of a common small subunit (calpain-4), and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain T in calpains 5 and 6). Located on the X chromosome, the calpain-6 sequence lacks the "EF hand" calcium-binding motif found in domain-IV of the classical calpains. In addition, the canonical active site Cys, His and Asn are modified to Lys, His, Asn in human and Lys, Tyr, Asn in mouse calpain-6, making it unlikely that calpain-6 is proteolytically active.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calpain-6; Calpain-like protease X-linked; Calpamodulin; CalpM
Gene Aliases: CALPM; CANPX; Capa6; CAPN6; CAPNX; DJ914P14.1
UniProt ID: (Human) Q9UJA8, (Mouse) O35646, (Rat) O88501
Entrez Gene ID: (Human) 827, (Mouse) 12338, (Rat) 83685
Molecular Function: cysteine protease
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support