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NeoBiotechnologies
Calretinin/Calbindin 2 (Mesothelioma Marker) Recombinant Rabbit Monoclonal Antibody (CALB2/7029R)
Product Details
794-RBM12-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CALB2/7029R
Immunogen
Recombinant human Calretinin (Calbindin 2) protein fragment (around aa23-242).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: Human brain, testis or mesothelioma tissue. Cellular Localization: Cytoplasm. Nucleus.
Specificity Comments: It recognizes a protein of about 29kDa, which is identified as Calretinin (also known as Calbindin 2). Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is present in subsets of neurons throughout the brain and spinal chord, including sensory ganglia. Antibody to calretinin is useful in differentiating mesothelioma from adeno carcinomas of the lung. It also aids in differentiating adrenal cortical neoplasms from pheochromocytomas.
Target Information
Calretinin is encoded by the CALB2 gene located on chromosome 16. It is a troponin C superfamily protein having six EF-hand structural motifs. The EF motif allows the protein to bind calcium, and function in calcium signaling, calcium buffering, and modulating neuronal excitability. Calretinin is expressed in the mesothelium, mast cells, some neural cells, hair follicles, and fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 29 kDa calbindin; 29kD calretinin; 29kDa calbindin; calbindin 2, (29kD, calretinin); calbindin D29K; Calretinin; CR; testicular secretory protein Li 8
Gene Aliases: CAB29; CAL2; CALB2; CR
UniProt ID: (Human) P22676
Entrez Gene ID: (Human) 794
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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