Alomone Labs, LTD

Cannabinoid Receptor 1 (extracellular) Polyclonal Antibody

View all (25) Cannabinoid Receptor 1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ACR-001-GP200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NKSLSSFKENEENIQC, corresponding to amino acid residues 84-99 of rat CB1 receptor, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Brain-type cannabinoid receptor; CANN6; Cannabinoid receptor 1; cannabinoid receptor 1 (brain); CB-R; CB1; CB1 receptor; central cannabinoid receptor; HGNC:2159; OTTHUMP00000016839; RP1-23D17.1; striatal cannabinoid receptor type 1 protein

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Gene Aliases: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR; CNR1; Skr6; SKR6R

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UniProt ID: (Human) P21554, (Mouse) P47746, (Rat) P20272

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Entrez Gene ID: (Human) 1268, (Mouse) 12801, (Rat) 25248

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Function(s)
cannabinoid receptor activity drug binding signal transducer activity G-protein coupled receptor activity protein binding G-protein coupled receptor
Process(es)
positive regulation of acute inflammatory response to antigenic stimulus G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-modulating G-protein coupled receptor signaling pathway spermatogenesis axonal fasciculation aging response to nutrient memory positive regulation of neuron projection development sensory perception of pain positive regulation of fever generation negative regulation of fatty acid beta-oxidation regulation of synaptic transmission, GABAergic response to lipopolysaccharide negative regulation of mast cell activation negative regulation of dopamine secretion response to nicotine cannabinoid signaling pathway response to cocaine glucose homeostasis positive regulation of apoptotic process negative regulation of ion transport response to morphine response to ethanol negative regulation of action potential negative regulation of blood pressure positive regulation of blood pressure regulation of insulin secretion negative regulation of nitric-oxide synthase activity regulation of synaptic transmission, glutamatergic maternal process involved in female pregnancy regulation of feeding behavior regulation of penile erection signal transduction G-protein coupled receptor signaling pathway learning or memory regulation of lipid metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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