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Invitrogen
Carbonic Anhydrase IX Recombinant Rabbit Monoclonal Antibody (005)
FIGURE: 1 / 4
Carbonic Anhydrase IX Antibody (MA5-52134) in IHC (P)
Immunohistochemistry analysis of Carbonic Anhydrase IX in formalin-fixed paraffin embedded human bladder carcinoma sections. Samples were incubated with Carbonic Anhydrase IX monoclonal antibody (Product # MA5-52134) using a dilution of 1:200.
Product Details
MA5-52134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
005
Immunogen
Recombinant Human Carbonic Anhydrase IX/CA9 protein (Gln 38-Asp414)
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CA-9; CA-IX; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; Membrane antigen MN; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Gene Aliases: CA9; CAIX; G250; MN
UniProt ID: (Human) Q16790
Entrez Gene ID: (Human) 768
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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