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Product Details
PA5-51325
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length fusion protein of human TNNC1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636772
Product Specific Information
The antibody detects endogenous levels of total Cardiac Troponin C protein.
Target Information
Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium-ion uptake by troponin-C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac 3; cardiac troponin C; CMD1FF; CMD2A; CMH7; MGC116817; RCM1; slow twitch skeletal/cardiac muscle troponin C; TN-C; Tn1; Tni; TNN I3; TNNC 1; TNNI3; troponin C type 1 (slow); Troponin C, slow skeletal and cardiac muscles; troponin C1, slow; Troponin I cardiac; TroponinI
Gene Aliases: AI874626; CMD1Z; CMH13; cTnC; cTnI; TN-C; TNC; Tncc; TNNC; TNNC1
UniProt ID: (Human) P63316, (Mouse) P19123
Entrez Gene ID: (Human) 7134, (Mouse) 21924
diaphragm contraction
skeletal muscle contraction
regulation of muscle contraction
response to metal ion
transition between fast and slow fiber
muscle filament sliding
regulation of muscle filament sliding speed
regulation of ATPase activity
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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