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Product Details
MA1-20116
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Cat,
Goat,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4C2
Immunogen
Full length, human cardiac troponin 1 protein.
Conjugate
Form
Liquid
Concentration
4.6 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
RRID
AB_561824
Product Specific Information
MA1-20116 detects cardiac troponin 1 in human, mouse, rat, bovine, feline, canine, porcine and rabbit samples.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac troponin I; cardiac troponin I isoform; cardiomyopathy, dilated 2A (autosomal recessive); cTnI; MGC116817; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); Troponin I, cardiac muscle; troponin I, cardiac muscle-like
Gene Aliases: CMD1FF; CMD2A; CMH7; Ctni; RCM1; Tn1; TnI; TNNC1; TNNI3
UniProt ID: (Cat) Q863B6, (Human) P19429, (Dog) Q8MKD5, (Bovine) P08057, (Rat) P23693, (Mouse) P48787
Entrez Gene ID: (Goat) 100860775, (Cat) 493744, (Human) 7137, (Pig) 100049696, (Dog) 403566, (Bovine) 511094, (Rat) 29248, (Mouse) 21954
actin binding
protein binding
calcium channel inhibitor activity
protein kinase binding
protein domain specific binding
troponin C binding
troponin T binding
metal ion binding
calcium-dependent protein binding
actin filament binding
magnesium ion binding
ATP binding
ATPase activity
non-motor actin binding protein
vasculogenesis
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
cellular calcium ion homeostasis
regulation of smooth muscle contraction
heart development
muscle filament sliding
negative regulation of ATPase activity
ventricular cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
regulation of cardiac conduction
regulation of cardiac muscle contraction by calcium ion signaling
regulation of muscle contraction
striated muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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