Product References
Hierarchical Topography with Tunable Micro- and Nanoarchitectonics for Highly Enhanced Cardiomyocyte Maturation via Multi-Scale Mechanotransduction.
Advanced healthcare materials
Ahn H,Cho Y,Yun GT,Jung KB,Jeong W,Kim Y,Son MY,Lee E,Im SG,Jung HT
MA5-12960 was used in Immunocytochemistry-immunofluorescence to demonstrate how a large family of hierarchical structures is used for cardiac maturation.
Mon May 01 00:00:00 EDT 2023
Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.
Cell reports methods
Dark N,Cosson MV,Tsansizi LI,Owen TJ,Ferraro E,Francis AJ,Tsai S,Bouissou C,Weston A,Collinson L,Abi-Gerges N,Miller PE,MacLeod KT,Ehler E,Mitter R,Harding SE,Smith JC,Bernardo AS
MA5-12960 was used in Immunocytochemistry to show that functionally matured hPSC-LV-CMs can be obtained rapidly without exposure to current maturation regimes.
Mon Apr 24 00:00:00 EDT 2023
Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism.
Nature communications
Srivastava S,Gajwani P,Jousma J,Miyamoto H,Kwon Y,Jana A,Toth PT,Yan G,Ong SG,Rehman J
MA5-12960 was used in Western Blotting to identify nuclear translocation of mitochondrial dehydrogenases as an endogenous adaptive mechanism that can be leveraged to attenuate cardiomyocyte injury.
Wed Jul 19 00:00:00 EDT 2023
Rosmarinic acid protects against lipopolysaccharide-induced cardiac dysfunction via activating Sirt1/PGC-1α pathway to alleviate mitochondrial impairment.
Clinical and experimental pharmacology & physiology
Peng K,Yang F,Qiu C,Yang Y,Lan C
MA5-12960 was used in Immunohistochemistry to show that RA attenuates LPS-induced cardiac dysfunction via activating Sirt1/PGC-1α pathway to alleviate mitochondrial impairment.
Wed Mar 01 00:00:00 EST 2023
Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation.
eLife
Galdos FX,Lee C,Lee S,Paige S,Goodyer W,Xu S,Samad T,Escobar GV,Darsha A,Beck A,Bak RO,Porteus MH,Wu SM
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Wed Jun 07 00:00:00 EDT 2023
Utilizing human induced pluripotent stem cells to study atrial arrhythmias in the short QT syndrome.
Journal of molecular and cellular cardiology
Shiti A,Arbil G,Shaheen N,Huber I,Setter N,Gepstein L
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2023
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovascular research
Liu T,Meng Z,Liu J,Li J,Zhang Y,Deng Z,Luo S,Wang M,Huang Q,Zhang S,Fendt P,Devouassoux J,Li D,McKenzie ANJ,Nahrendorf M,Libby P,Guo J,Shi GP
MA5-12960 was used in Immunohistochemistry-immunofluorescence to reveal an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
Tue May 02 00:00:00 EDT 2023
Thymosin β4 and prothymosin α promote cardiac regeneration post-ischaemic injury in mice.
Cardiovascular research
Gladka MM,Johansen AKZ,van Kampen SJ,Peters MMC,Molenaar B,Versteeg D,Kooijman L,Zentilin L,Giacca M,van Rooij E
MA5-12960 was used in Immunohistochemistry-immunofluorescence to indicate that in addition to activating cardiomyocyte proliferation, a supportive environment is a key for regeneration to occur.
Tue May 02 00:00:00 EDT 2023
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs.
Proceedings of the National Academy of Sciences of the United States of America
Eguchi A,Gonzalez AFGS,Torres-Bigio SI,Koleckar K,Birnbaum F,Zhang JZ,Wang VY,Wu JC,Artandi SE,Blau HM
MA5-12960 was used in Flow Cytometry to provide evidence that preventing telomere attrition ameliorates deficits in cell morphology, activation of the DNA damage response, and premature cell death, suggesting that TRF2 is a key player in DMD-associated cardiac failure.
Tue Feb 07 00:00:00 EST 2023
FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes.
Frontiers in cardiovascular medicine
Murganti F,Derks W,Baniol M,Simonova I,Trus P,Neumann K,Khattak S,Guan K,Bergmann O
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sat Jul 16 00:00:00 EDT 2022
Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure.
Frontiers in cardiovascular medicine
Wu P,Li Y,Cai M,Ye B,Geng B,Li F,Zhu H,Liu J,Wang X
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Fri Apr 29 00:00:00 EDT 2022
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.
Journal of cardiovascular pharmacology
Wang Y,Li X,Xu X,Qu X,Yang Y
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Sep 01 00:00:00 EDT 2022
CD47 antibody protects mice from doxorubicin-induced myocardial damage by suppressing cardiomyocyte apoptosis.
Experimental and therapeutic medicine
Hao Y,Chen L,Jiang Z
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sun May 01 00:00:00 EDT 2022
CD47 antibody protects mice from doxorubicin-induced myocardial damage by suppressing cardiomyocyte apoptosis.
Experimental and therapeutic medicine
Hao Y,Chen L,Jiang Z
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sun May 01 00:00:00 EDT 2022
Persistent fibrosis and decreased cardiac function following cardiac injury in the Ctenopharyngodon idella (grass carp).
Anatomical record (Hoboken, N.J. : 2007)
Long DW,Webb CH,Wang Y
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sat Jan 01 00:00:00 EST 2022
CIEGAN: A Deep Learning Tool for Cell Image Enhancement.
Frontiers in genetics
Sun Q,Yang X,Guo J,Zhao Y,Liu Y
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Jul 26 00:00:00 EDT 2022
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates.
NPJ Regenerative medicine
Birnbaum F,Eguchi A,Pardon G,Chang ACY,Blau HM
MA5-12960 was used in Immunocytochemistry to examine the effects of chronic 4-hydroxytamoxifen treatment.
Fri Mar 18 00:00:00 EDT 2022
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates.
NPJ Regenerative medicine
Birnbaum F,Eguchi A,Pardon G,Chang ACY,Blau HM
MA5-12960 was used in Immunocytochemistry to examine the effects of chronic 4-hydroxytamoxifen treatment.
Fri Mar 18 00:00:00 EDT 2022
Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo.
Communications biology
Miller JM,Meki MH,Elnakib A,Ou Q,Abouleisa RRE,Tang XL,Salama ABM,Gebreil A,Lin C,Abdeltawab H,Khalifa F,Hill BG,Abi-Gerges N,Bolli R,El-Baz AS,Giridharan GA,Mohamed TMA
MA5-12960 was used in Immunohistochemistry to conclude that CTCM can emulate cardiac physiology and pathophysiology in culture for an extended time, thereby enabling reliable drug screening.
Fri Sep 09 00:00:00 EDT 2022
Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo.
Communications biology
Miller JM,Meki MH,Elnakib A,Ou Q,Abouleisa RRE,Tang XL,Salama ABM,Gebreil A,Lin C,Abdeltawab H,Khalifa F,Hill BG,Abi-Gerges N,Bolli R,El-Baz AS,Giridharan GA,Mohamed TMA
MA5-12960 was used in Immunohistochemistry to conclude that CTCM can emulate cardiac physiology and pathophysiology in culture for an extended time, thereby enabling reliable drug screening.
Fri Sep 09 00:00:00 EDT 2022
Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period.
Frontiers in synaptic neuroscience
Haburčák M,Harrison J,Buyukozturk MM,Sona S,Bates S,Birren SJ
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Feb 09 00:00:00 EST 2023
Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period.
Frontiers in synaptic neuroscience
Haburčák M,Harrison J,Buyukozturk MM,Sona S,Bates S,Birren SJ
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Feb 09 00:00:00 EST 2023
Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes.
iScience
Acharya A,Nemade H,Papadopoulos S,Hescheler J,Neumaier F,Schneider T,Rajendra Prasad K,Khan K,Hemmersbach R,Gusmao EG,Mizi A,Papantonis A,Sachinidis A
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Fri Jul 15 00:00:00 EDT 2022
A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues.
Journal of personalized medicine
Ribeiro MC,Rivera-Arbeláez JM,Cofiño-Fabres C,Schwach V,Slaats RH,Ten Den SA,Vermeul K,van den Berg A,Pérez-Pomares JM,Segerink LI,Guadix JA,Passier R
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry (PFA fixed)
Fri Feb 04 00:00:00 EST 2022
Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction.
EBioMedicine
Lan C,Chen C,Qu S,Cao N,Luo H,Yu C,Wang N,Xue Y,Xia X,Fan C,Ren H,Yang Y,Jose PA,Xu Z,Wu G,Zeng C
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Sample Prep to reveal a significant role of DYRK1A in cardiac repair and suggest a drug target with translational potential for treating cardiomyopathy.
Mon Aug 01 00:00:00 EDT 2022
Human in vitro neurocardiac coculture (ivNCC) assay development for evaluating cardiac contractility modulation.
Physiological reports
Narkar A,Feaster TK,Casciola M,Blinova K
MA5-12960 was used in Immunocytochemistry-immunofluorescence to provides novel characterization of cardiac contractility modulation effects on hiPSC-derived neurocardiac cocultures.
Tue Nov 01 00:00:00 EDT 2022
devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data.
Nature communications
Galdos FX,Xu S,Goodyer WR,Duan L,Huang YV,Lee S,Zhu H,Lee C,Wei N,Lee D,Wu SM
MA5-12960 was used in Flow cytometry/Cell sorting to present devCellPy a highly accurate and precise machine learning-enabled tool that enables automated prediction of cell types across complex annotation hierarchies.
Wed Sep 07 00:00:00 EDT 2022
devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data.
Nature communications
Galdos FX,Xu S,Goodyer WR,Duan L,Huang YV,Lee S,Zhu H,Lee C,Wei N,Lee D,Wu SM
MA5-12960 was used in Flow cytometry/Cell sorting to present devCellPy a highly accurate and precise machine learning-enabled tool that enables automated prediction of cell types across complex annotation hierarchies.
Wed Sep 07 00:00:00 EDT 2022
GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy.
Journal of cellular and molecular medicine
Volani C,Pagliaro A,Rainer J,Paglia G,Porro B,Stadiotti I,Foco L,Cogliati E,Paolin A,Lagrasta C,Frati C,Corradini E,Falco A,Matzinger T,Picard A,Ermon B,Piazza S,De Bortoli M,Tondo C,Philippe R,Medici A,Lavdas AA,Blumer MJF,Pompilio G,Sommariva E,Pramstaller PP,Troppmair J,Meraviglia V,Rossini A
MA5-12960 was used in Immunohistochemistry-immunofluorescence to suggest that GCN5 inhibition reduces fat accumulation in ACM CStCs, partially by modulating intracellular redox balance pathways.
Fri Jul 01 00:00:00 EDT 2022
DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal.
Nature communications
Cattaneo P,Hayes MGB,Baumgarten N,Hecker D,Peruzzo S,Aslan GS,Kunderfranco P,Larcher V,Zhang L,Contu R,Fonseca G,Spinozzi S,Chen J,Condorelli G,Dimmeler S,Schulz MH,Heinz S,Guimarães-Camboa N,Evans SM
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to reveal that H3K79me2 regulates highly specific transcriptional networks during embryonic cardiogenesis and postnatal cardiomyocyte cell cycle withdrawal.
Fri Dec 02 00:00:00 EST 2022
Artificial Intelligence Based Framework to Quantify the Cardiomyocyte Structural Integrity in Heart Slices.
Cardiovascular engineering and technology
Abdeltawab H,Khalifa F,Hammouda K,Miller JM,Meki MM,Ou Q,El-Baz A,Mohamed TMA
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to propose an image-based deep learning pipeline for the automated quantification of drug induced structural deteriorations using a 3D heart slice culture model.
Tue Feb 01 00:00:00 EST 2022
Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity.
Frontiers in cardiovascular medicine
Tsuruda T,Sato Y,Tomita M,Tanaka H,Hatakeyama K,Otsu M,Kawano A,Nagatomo K,Yoshikawa N,Ikeda R,Asada Y,Kaikita K
MA5-12960 was used in Immunohistochemistry to evaluate the expression of TNNT2 in neoplastic tissues.
Sat Apr 30 00:00:00 EDT 2022
Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes.
Cell reports
Afzal J,Liu Y,Du W,Suhail Y,Zong P,Feng J,Ajeti V,Sayyad WA,Nikolaus J,Yankova M,Deymier AC,Yue L
MA5-12960 was used in Flow cytometry/Cell sorting to present a method to accelerate hiPSC-CM maturation on a substrate, cardiac mimetic matrix (CMM), mimicking adult human heart matrix ligand chemistry, rigidity, and submicron ultrastructure, which synergistically mature hiPSC-CMs rapidly within 30 days.
Tue Jul 26 00:00:00 EDT 2022
BNIP3L/NIX regulates both mitophagy and pexophagy.
The EMBO journal
Wilhelm LP,Zapata-Muñoz J,Villarejo-Zori B,Pellegrin S,Freire CM,Toye AM,Boya P,Ganley IG
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to uncover a dual role for NIX, not only in mitophagy but also in pexophagy, thus illustrating the interconnection between selective autophagy pathways.
Thu Dec 15 00:00:00 EST 2022
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xu H,Liu G,Gong J,Zhang Y,Gu S,Wan Z,Yang P,Nie Y,Wang Y,Huang ZP,Luo G,Chen Z,Zhang D,Cao N
MA5-12960 was used in Immunocytochemistry-immunofluorescence to demonstrate that four antiviral drugs, namely, apilimod, remdesivir, ritonavir, and lopinavir, exhibit cardiotoxicity in terms of inducing cell death, sarcomere disarray, and dysregulation of calcium handling and contraction, at clinically relevant concentrations, using human pluripotent stem cell-derived cardiomyocytes (hCMs).
Sat Oct 01 00:00:00 EDT 2022
Modeling long QT syndrome type 2 on-a-chip via in-depth assessment of isogenic gene-edited 3D cardiac tissues.
Science advances
Veldhuizen J,Mann HF,Karamanova N,Van Horn WD,Migrino RQ,Brafman D,Nikkhah M
MA5-12960 was used in Immunohistochemistry-immunofluorescence to develop a LQTS2-diseased tissue-on-a-chip model, using 3D coculture of isogenic stem cell-derived cardiomyocytes (CMs) and cardiac fibroblasts (CFs) within an organotypic microfluidic chip technology.
Fri Dec 16 00:00:00 EST 2022
An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates.
Cell reports methods
Tischler J,Swank Z,Hsiung HA,Vianello S,Lutolf MP,Maerkl SJ
MA5-12960 was used in Immunocytochemistry-immunoflourescence to demonstrate a highly versatile and scalable tool that can be adapted to specific research questions, experimental demands, and model systems.
Mon Jul 18 00:00:00 EDT 2022
Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
eLife
Jiang FQ,Liu K,Chen JX,Cao Y,Chen WY,Zhao WL,Song GH,Liang CQ,Zhou YM,Huang HL,Huang RJ,Zhao H,Park KS,Ju Z,Cai D,Qi XF
MA5-12960 was used in In vitro experiments to demonstrate that Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m6A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
Fri Nov 18 00:00:00 EST 2022
Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
eLife
Jiang FQ,Liu K,Chen JX,Cao Y,Chen WY,Zhao WL,Song GH,Liang CQ,Zhou YM,Huang HL,Huang RJ,Zhao H,Park KS,Ju Z,Cai D,Qi XF
MA5-12960 was used in In vitro experiments to demonstrate that Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m6A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
Fri Nov 18 00:00:00 EST 2022
Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway.
BMC biology
Shen X,Li M,Wang C,Liu Z,Wu K,Wang A,Bi C,Lu S,Long H,Zhu G
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Wed Oct 05 00:00:00 EDT 2022
A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-edited rat model with Duchenne muscular dystrophy.
Scientific reports
Fujikura Y,Kimura K,Yamanouchi K,Sugihara H,Hatakeyama M,Zhuang H,Abe T,Daimon M,Morita H,Komuro I,Oishi K
MA5-12960 was used in Immunohistochemistry to clarify whether medium-chain triglyceride containing ketogenic diet also improves the cardiomyopathy in these rats.
Fri Jul 08 00:00:00 EDT 2022
PD1 Deficiency Modifies Cardiac Immunity during Baseline Conditions and in Reperfused Acute Myocardial Infarction.
International journal of molecular sciences
Michel L,Korste S,Spomer A,Hendgen-Cotta UB,Rassaf T,Totzeck M
MA5-12960 was used in Immunohistochemistry to highlight the risk for adverse outcomes from acute myocardial infarction in the growing group of patients receiving immune checkpoint inhibitor therapy.
Thu Jul 07 00:00:00 EDT 2022
Human heart-forming organoids recapitulate early heart and foregut development.
Nature biotechnology
Drakhlis L,Biswanath S,Farr CM,Lupanow V,Teske J,Ritzenhoff K,Franke A,Manstein F,Bolesani E,Kempf H,Liebscher S,Schenke-Layland K,Hegermann J,Nolte L,Meyer H,de la Roche J,Thiemann S,Wahl-Schott C,Martin U,Zweigerdt R
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Jun 01 00:00:00 EDT 2021
Human heart-forming organoids recapitulate early heart and foregut development.
Nature biotechnology
Drakhlis L,Biswanath S,Farr CM,Lupanow V,Teske J,Ritzenhoff K,Franke A,Manstein F,Bolesani E,Kempf H,Liebscher S,Schenke-Layland K,Hegermann J,Nolte L,Meyer H,de la Roche J,Thiemann S,Wahl-Schott C,Martin U,Zweigerdt R
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Jun 01 00:00:00 EDT 2021
Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo.
Circulation
El-Nachef D,Bugg D,Beussman KM,Steczina S,Martinson AM,Murry CE,Sniadecki NJ,Davis J
MA5-12960 was used in Immunocytochemistry to genetically engineer a cardiomyocyte-specific fluorescent barcoding system into an hPSC line.
Tue Apr 20 00:00:00 EDT 2021
Capturing Cardiogenesis in Gastruloids.
Cell stem cell
Rossi G,Broguiere N,Miyamoto M,Boni A,Guiet R,Girgin M,Kelly RG,Kwon C,Lutolf MP
MA5-12960 was used in Immunohistochemistry to unveil the surprising morphogenetic potential of mESCs to execute key aspects of organogenesis through the coordinated development of multiple tissues.
Thu Feb 04 00:00:00 EST 2021
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling.
Cardiovascular research
Ebeid DE,Khalafalla FG,Broughton KM,Monsanto MM,Esquer CY,Sacchi V,Hariharan N,Korski KI,Moshref M,Emathinger J,Cottage CT,Quijada PJ,Nguyen JH,Alvarez R,Völkers M,Konstandin MH,Wang BJ,Firouzi F,Navarrete JM,Gude NA,Goumans MJ,Sussman MA
MA5-12960 was used in Immunohistochemistry to delineate the mechanism of telomere length regulation by the interplay between Pim1 and components of TGFβ signaling pathways.
Fri Jan 01 00:00:00 EST 2021
Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices.
Biomaterials science
DePalma SJ,Davidson CD,Stis AE,Helms AS,Baker BM
MA5-12960 was used in Immunocytochemistry to demonstrate the importance of recapitulating the fibrous myocardial ECM in engineering structurally organized and functional iPSC-CM tissues.
Tue Jan 05 00:00:00 EST 2021
Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
Molecular medicine (Cambridge, Mass.)
Fu J,Tang Y,Zhang Z,Tong L,Yue R,Cai L
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Thu Aug 19 00:00:00 EDT 2021
Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
Molecular medicine (Cambridge, Mass.)
Fu J,Tang Y,Zhang Z,Tong L,Yue R,Cai L
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Thu Aug 19 00:00:00 EDT 2021
Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury.
Frontiers in cell and developmental biology
Zhao H,Zhang Y,Xu X,Sun Q,Yang C,Wang H,Yang J,Yang Y,Yang X,Liu Y,Zhao Y
MA5-12960 was used in Immunocytochemistry to develop genetic cocktails that induce cardiac reprogramming directly in cultured cardiac fibroblasts isolated from adult mice with myocardial infarction (MICFs), which could be more relevant to heart diseases.
Tue Sep 19 00:00:00 EDT 2023
Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury.
Frontiers in cell and developmental biology
Zhao H,Zhang Y,Xu X,Sun Q,Yang C,Wang H,Yang J,Yang Y,Yang X,Liu Y,Zhao Y
MA5-12960 was used in Immunocytochemistry to develop genetic cocktails that induce cardiac reprogramming directly in cultured cardiac fibroblasts isolated from adult mice with myocardial infarction (MICFs), which could be more relevant to heart diseases.
Tue Sep 19 00:00:00 EDT 2023
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.
PeerJ
Salerno JA,Torquato T,Temerozo JR,Goto-Silva L,Karmirian K,Mendes MA,Sacramento CQ,Fintelman-Rodrigues N,Souza LRQ,Ornelas IM,Veríssimo CP,Aragão LGHS,Vitória G,Pedrosa CSG,da Silva Gomes Dias S,Cardoso Soares V,Puig-Pijuan T,Salazar V,Dariolli R,Biagi D,Furtado DR,Barreto Chiarini L,Borges HL,Bozza PT,Zaluar P Guimarães M,Souza TML,Rehen SK
MA5-12960 was used in Flow Cytometry, Immunocytochemistry to investigated the consequences of the inhibition of the Sigma-1 receptor, a ubiquitously expressed chaperone that plays a central role in cardiomyocyte function, in iPSC-derived human cardiomyocytes on the basis that it may affect SARS-CoV-2 replication.
Wed Nov 08 00:00:00 EST 2023
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.
PeerJ
Salerno JA,Torquato T,Temerozo JR,Goto-Silva L,Karmirian K,Mendes MA,Sacramento CQ,Fintelman-Rodrigues N,Souza LRQ,Ornelas IM,Veríssimo CP,Aragão LGHS,Vitória G,Pedrosa CSG,da Silva Gomes Dias S,Cardoso Soares V,Puig-Pijuan T,Salazar V,Dariolli R,Biagi D,Furtado DR,Barreto Chiarini L,Borges HL,Bozza PT,Zaluar P Guimarães M,Souza TML,Rehen SK
MA5-12960 was used in Flow Cytometry, Immunocytochemistry to investigated the consequences of the inhibition of the Sigma-1 receptor, a ubiquitously expressed chaperone that plays a central role in cardiomyocyte function, in iPSC-derived human cardiomyocytes on the basis that it may affect SARS-CoV-2 replication.
Wed Nov 08 00:00:00 EST 2023
Non-permissive SARS-CoV-2 infection in human neurospheres.
Stem cell research
Pedrosa CDSG,Goto-Silva L,Temerozo JR,Souza LRQ,Vitória G,Ornelas IM,Karmirian K,Mendes MA,Gomes IC,Sacramento CQ,Fintelman-Rodrigues N,Cardoso Soares V,Silva Gomes Dias SD,Salerno JA,Puig-Pijuan T,Oliveira JT,Aragão LGHS,Torquato TCQ,Veríssimo C,Biagi D,Cruvinel EM,Dariolli R,Furtado DR,Borges HL,Bozza PT,Rehen S,Moreno L Souza T,Guimarães MZP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Jul 01 00:00:00 EDT 2021
Non-permissive SARS-CoV-2 infection in human neurospheres.
Stem cell research
Pedrosa CDSG,Goto-Silva L,Temerozo JR,Souza LRQ,Vitória G,Ornelas IM,Karmirian K,Mendes MA,Gomes IC,Sacramento CQ,Fintelman-Rodrigues N,Cardoso Soares V,Silva Gomes Dias SD,Salerno JA,Puig-Pijuan T,Oliveira JT,Aragão LGHS,Torquato TCQ,Veríssimo C,Biagi D,Cruvinel EM,Dariolli R,Furtado DR,Borges HL,Bozza PT,Rehen S,Moreno L Souza T,Guimarães MZP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Jul 01 00:00:00 EDT 2021
Non-permissive SARS-CoV-2 infection in human neurospheres.
Stem cell research
Pedrosa CDSG,Goto-Silva L,Temerozo JR,Souza LRQ,Vitória G,Ornelas IM,Karmirian K,Mendes MA,Gomes IC,Sacramento CQ,Fintelman-Rodrigues N,Cardoso Soares V,Silva Gomes Dias SD,Salerno JA,Puig-Pijuan T,Oliveira JT,Aragão LGHS,Torquato TCQ,Veríssimo C,Biagi D,Cruvinel EM,Dariolli R,Furtado DR,Borges HL,Bozza PT,Rehen S,Moreno L Souza T,Guimarães MZP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Jul 01 00:00:00 EDT 2021
Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors.
Stem cell research & therapy
Borys BS,Dang T,So T,Rohani L,Revay T,Walsh T,Thompson M,Argiropoulos B,Rancourt DE,Jung S,Hashimura Y,Lee B,Kallos MS
MA5-12960 was used in Immunocytochemistry to develop a scalable, single-cell inoculation protocol for the culture of hiPSCs as aggregates in vertical-wheel bioreactors, achieving over 30-fold expansion in 6 days without sacrificing cell quality.
Wed Jan 13 00:00:00 EST 2021
Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors.
Stem cell research & therapy
Borys BS,Dang T,So T,Rohani L,Revay T,Walsh T,Thompson M,Argiropoulos B,Rancourt DE,Jung S,Hashimura Y,Lee B,Kallos MS
MA5-12960 was used in Immunocytochemistry to develop a scalable, single-cell inoculation protocol for the culture of hiPSCs as aggregates in vertical-wheel bioreactors, achieving over 30-fold expansion in 6 days without sacrificing cell quality.
Wed Jan 13 00:00:00 EST 2021
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Scientific reports
Francisco J,Zhang Y,Nakada Y,Jeong JI,Huang CY,Ivessa A,Oka S,Babu GJ,Del Re DP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue May 18 00:00:00 EDT 2021
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Scientific reports
Francisco J,Zhang Y,Nakada Y,Jeong JI,Huang CY,Ivessa A,Oka S,Babu GJ,Del Re DP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue May 18 00:00:00 EDT 2021
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Scientific reports
Francisco J,Zhang Y,Nakada Y,Jeong JI,Huang CY,Ivessa A,Oka S,Babu GJ,Del Re DP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue May 18 00:00:00 EDT 2021
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Scientific reports
Francisco J,Zhang Y,Nakada Y,Jeong JI,Huang CY,Ivessa A,Oka S,Babu GJ,Del Re DP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue May 18 00:00:00 EDT 2021
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Scientific reports
Francisco J,Zhang Y,Nakada Y,Jeong JI,Huang CY,Ivessa A,Oka S,Babu GJ,Del Re DP
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue May 18 00:00:00 EDT 2021
High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias.
Frontiers in pharmacology
Honda Y,Li J,Hino A,Tsujimoto S,Lee JK
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sat Aug 21 00:00:00 EDT 2021
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes.
Stem cell reports
Nakamura K,Neidig LE,Yang X,Weber GJ,El-Nachef D,Tsuchida H,Dupras S,Kalucki FA,Jayabalu A,Futakuchi-Tsuchida A,Nakamura DS,Marchianò S,Bertero A,Robinson MR,Cain K,Whittington D,Tian R,Reinecke H,Pabon L,Knollmann BC,Kattman S,Thies RS,MacLellan WR,Murry CE
MA5-12960 was used in Immunohistochemistry to show that pharmacologic treatment of EA may be a viable strategy to improve safety and allow further clinical development of cardiac remuscularization therapy.
Tue Oct 12 00:00:00 EDT 2021
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes.
Stem cell reports
Nakamura K,Neidig LE,Yang X,Weber GJ,El-Nachef D,Tsuchida H,Dupras S,Kalucki FA,Jayabalu A,Futakuchi-Tsuchida A,Nakamura DS,Marchianò S,Bertero A,Robinson MR,Cain K,Whittington D,Tian R,Reinecke H,Pabon L,Knollmann BC,Kattman S,Thies RS,MacLellan WR,Murry CE
MA5-12960 was used in Immunohistochemistry to show that pharmacologic treatment of EA may be a viable strategy to improve safety and allow further clinical development of cardiac remuscularization therapy.
Tue Oct 12 00:00:00 EDT 2021
Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice.
Frontiers in immunology
Okajima T,Shigemori S,Namai F,Ogita T,Sato T,Shimosato T
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Fri Dec 17 00:00:00 EST 2021
Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice.
Frontiers in immunology
Okajima T,Shigemori S,Namai F,Ogita T,Sato T,Shimosato T
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Fri Dec 17 00:00:00 EST 2021
Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.
International journal of molecular sciences
Jang JH,Kim MS,Antao AM,Jo WJ,Kim HJ,Kim SJ,Choi MJ,Ramakrishna S,Kim KS
MA5-12960 was used in Immunocytochemistry to identify cP1P as a novel factor that significantly enhances the differentiation potential of hESCs into cardiomyocytes.
Tue Jun 29 00:00:00 EDT 2021
Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.
International journal of molecular sciences
Jang JH,Kim MS,Antao AM,Jo WJ,Kim HJ,Kim SJ,Choi MJ,Ramakrishna S,Kim KS
MA5-12960 was used in Immunocytochemistry to identify cP1P as a novel factor that significantly enhances the differentiation potential of hESCs into cardiomyocytes.
Tue Jun 29 00:00:00 EDT 2021
Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.
International journal of molecular sciences
Jang JH,Kim MS,Antao AM,Jo WJ,Kim HJ,Kim SJ,Choi MJ,Ramakrishna S,Kim KS
MA5-12960 was used in Immunocytochemistry to identify cP1P as a novel factor that significantly enhances the differentiation potential of hESCs into cardiomyocytes.
Tue Jun 29 00:00:00 EDT 2021
Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids.
International journal of molecular sciences
Souidi M,Sleiman Y,Acimovic I,Pribyl J,Charrabi A,Baecker V,Scheuermann V,Pesl M,Jelinkova S,Skladal P,Dvorak P,Lacampagne A,Rotrekl V,Meli AC
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Mon Jan 11 00:00:00 EST 2021
Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids.
International journal of molecular sciences
Souidi M,Sleiman Y,Acimovic I,Pribyl J,Charrabi A,Baecker V,Scheuermann V,Pesl M,Jelinkova S,Skladal P,Dvorak P,Lacampagne A,Rotrekl V,Meli AC
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Mon Jan 11 00:00:00 EST 2021
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.
JCI insight
Cohen ED,Yee M,Porter GA,Ritzer E,McDavid AN,Brookes PS,Pryhuber GS,O'Reilly MA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry (PFA fixed)
Mon Mar 08 00:00:00 EST 2021
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.
JCI insight
Cohen ED,Yee M,Porter GA,Ritzer E,McDavid AN,Brookes PS,Pryhuber GS,O'Reilly MA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry (PFA fixed)
Mon Mar 08 00:00:00 EST 2021
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.
JCI insight
Cohen ED,Yee M,Porter GA,Ritzer E,McDavid AN,Brookes PS,Pryhuber GS,O'Reilly MA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry (PFA fixed)
Mon Mar 08 00:00:00 EST 2021
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels.
Nature communications
Daly AC,Davidson MD,Burdick JA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Feb 02 00:00:00 EST 2021
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels.
Nature communications
Daly AC,Davidson MD,Burdick JA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Feb 02 00:00:00 EST 2021
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels.
Nature communications
Daly AC,Davidson MD,Burdick JA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Feb 02 00:00:00 EST 2021
Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation.
Scientific reports
Xing S,Tian JZ,Yang SH,Huang XT,Ding YF,Lu QY,Yang JS,Yang WJ
MA5-12960 was used in Immunohistochemistry to show that Setd4 epigenetically controls c-Kit+ cell quiescence in the adult heart by facilitating heterochromatin formation via H4K20me3.
Wed Jun 02 00:00:00 EDT 2021
Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation.
Scientific reports
Xing S,Tian JZ,Yang SH,Huang XT,Ding YF,Lu QY,Yang JS,Yang WJ
MA5-12960 was used in Immunohistochemistry to show that Setd4 epigenetically controls c-Kit+ cell quiescence in the adult heart by facilitating heterochromatin formation via H4K20me3.
Wed Jun 02 00:00:00 EDT 2021
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Nature communications
Cui M,Atmanli A,Morales MG,Tan W,Chen K,Xiao X,Xu L,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Mon Sep 06 00:00:00 EDT 2021
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Nature communications
Cui M,Atmanli A,Morales MG,Tan W,Chen K,Xiao X,Xu L,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Mon Sep 06 00:00:00 EDT 2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
The Journal of experimental medicine
Li J,Conrad C,Mills TW,Berg NK,Kim B,Ruan W,Lee JW,Zhang X,Yuan X,Eltzschig HK
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry to show that netrin-1 levels are elevated in the blood of patients with myocardial infarction, as well as in mice exposed to myocardial ischemia-reperfusion.
Mon Jun 07 00:00:00 EDT 2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
The Journal of experimental medicine
Li J,Conrad C,Mills TW,Berg NK,Kim B,Ruan W,Lee JW,Zhang X,Yuan X,Eltzschig HK
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry to show that netrin-1 levels are elevated in the blood of patients with myocardial infarction, as well as in mice exposed to myocardial ischemia-reperfusion.
Mon Jun 07 00:00:00 EDT 2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
The Journal of experimental medicine
Li J,Conrad C,Mills TW,Berg NK,Kim B,Ruan W,Lee JW,Zhang X,Yuan X,Eltzschig HK
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry to show that netrin-1 levels are elevated in the blood of patients with myocardial infarction, as well as in mice exposed to myocardial ischemia-reperfusion.
Mon Jun 07 00:00:00 EDT 2021
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes.
Nature communications
Miki K,Deguchi K,Nakanishi-Koakutsu M,Lucena-Cacace A,Kondo S,Fujiwara Y,Hatani T,Sasaki M,Naka Y,Okubo C,Narita M,Takei I,Napier SC,Sugo T,Imaichi S,Monjo T,Ando T,Tamura N,Imahashi K,Nishimoto T,Yoshida Y
MA5-12960 was used in Immunocytochemistry to study mature sub-populations of cardiomyocytes during cardiac differentiation using human induced pluripotent stem cells.
Mon Jun 21 00:00:00 EDT 2021
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Cell reports
Pettinato AM,Yoo D,VanOudenhove J,Chen YS,Cohn R,Ladha FA,Yang X,Thakar K,Romano R,Legere N,Meredith E,Robson P,Regnier M,Cotney JL,Murry CE,Hinson JT
MA5-12960 was used in Western Blotting to show that cardiomyocyte engraftment in infarcted rat hearts is enhanced 4-fold by the increased proliferation of troponin-knockout cardiomyocytes.
Tue May 04 00:00:00 EDT 2021
Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.
Cells
Jeż M,Martyniak A,Andrysiak K,Mucha O,Szade K,Kania A,Chrobok Ł,Palus-Chramiec K,Sanetra AM,Lewandowski MH,Pośpiech E,Stępniewski J,Dulak J
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis.
NPJ Regenerative medicine
Wu HY,Zhou YM,Liao ZQ,Zhong JW,Liu YB,Zhao H,Liang CQ,Huang RJ,Park KS,Feng SS,Zheng L,Cai DQ,Qi XF
MA5-12960 was used in Immunohistochemistry to demonstrate that cardiomyocyte proliferation greatly contributes to heart regeneration in adult X. tropicalis upon apex resection.
Tue Jun 29 00:00:00 EDT 2021
Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity.
Scientific reports
Sapp V,Aguirre A,Mainkar G,Ding J,Adler E,Liao R,Sharma S,Jain M
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to provide a technical framework for genome-wide functional screening in iPS derived cells and identify new targets to mitigate doxorubicin-cardiotoxicity in humans.
Tue Jul 06 00:00:00 EDT 2021
Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density.
Scientific reports
Le MNT,Takahi M,Ohnuma K
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density.
Scientific reports
Le MNT,Takahi M,Ohnuma K
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction.
NPJ Regenerative medicine
Peng H,Shindo K,Donahue RR,Gao E,Ahern BM,Levitan BM,Tripathi H,Powell D,Noor A,Elmore GA,Satin J,Seifert AW,Abdel-Latif A
MA5-12960 was used in Immunohistochemistry-immunofluorescence to demonstrate augmented myocardial preservation in spiny mice post-MI and establish Acomys as a new adult mammalian model for cardiac research.
Wed Nov 17 00:00:00 EST 2021
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.
Cell death discovery
Qian B,Wang P,Zhang D,Wu L
MA5-12960 was used in Immunocytochemistry to investigate the relationship between N6-methyladenosine and miRNA repression during heart development and hypertrophy.
Sat Jun 26 00:00:00 EDT 2021
Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling.
Journal of molecular and cellular cardiology
Shen S,Sewanan LR,Campbell SG
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to provide a mechanistic rationale for designing potential therapies to encourage reverse remodeling in patient hearts.
Wed Sep 01 00:00:00 EDT 2021
Molecular-scale visualization of sarcomere contraction within native cardiomyocytes.
Nature communications
Burbaum L,Schneider J,Scholze S,Böttcher RT,Baumeister W,Schwille P,Plitzko JM,Jasnin M
MA5-12960 was used in Immunocytochemistry to provide direct evidence for thin filament sliding during muscle contraction and may serve as a basis for structural understanding of thin filament activation and actomyosin interactions inside unperturbed cellular environments.
Fri Jul 02 00:00:00 EDT 2021
Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies.
JCI insight
Chour T,Tian L,Lau E,Thomas D,Itzhaki I,Malak O,Zhang JZ,Qin X,Wardak M,Liu Y,Chandy M,Black KE,Lam MP,Neofytou E,Wu JC
MA5-12960 was used in Flow cytometry/Cell sorting to overcome the risk of teratoma formation after cell transplantation due to the proliferative capacity of residual undifferentiated human pluripotent stem cells in differentiation batches.
Thu Apr 08 00:00:00 EDT 2021
Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.
The FEBS journal
Rozier R,Paul R,Madji Hounoum B,Villa E,Mhaidly R,Chiche J,Verhoeyen E,Marchetti S,Vandenberghe A,Raucoules M,Carles M,Ricci JE
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to identify a signaling pathway allowing APc of cardiac injuries as well as a rational for the use of MET as a pharmacological preconditioning agent to prevent I/R injuries.
Tue Jun 01 00:00:00 EDT 2021
Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing.
Developmental cell
Cui M,Wang Z,Chen K,Shah AM,Tan W,Duan L,Sanchez-Ortiz E,Li H,Xu L,Liu N,Bassel-Duby R,Olson EN
MA5-12960 was used in Immunohistochemistry to identify immature cardiomyocytes that enter the cell cycle following injury and disappear as the heart loses the ability to regenerate.
Mon Apr 06 00:00:00 EDT 2020
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity.
Cardiovascular research
Tsai SY,Ghazizadeh Z,Wang HJ,Amin S,Ortega FA,Badieyan ZS,Hsu ZT,Gordillo M,Kumar R,Christini DJ,Evans T,Chen S
MA5-12960 was used in Immunocytochemistry-immunoflourescence to create two MYH6:mCherry hESC reporter lines and documented the application of these lines for disease modelling relevant to cardiomyocyte biology.
Sun Mar 01 00:00:00 EST 2020
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.
Cell proliferation
Lan C,Cao N,Chen C,Qu S,Fan C,Luo H,Zeng A,Yu C,Xue Y,Ren H,Li L,Wang H,Jose PA,Xu Z,Zeng C
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sun Nov 01 00:00:00 EDT 2020
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.
Cell proliferation
Lan C,Cao N,Chen C,Qu S,Fan C,Luo H,Zeng A,Yu C,Xue Y,Ren H,Li L,Wang H,Jose PA,Xu Z,Zeng C
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sun Nov 01 00:00:00 EDT 2020
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.
Cell proliferation
Lan C,Cao N,Chen C,Qu S,Fan C,Luo H,Zeng A,Yu C,Xue Y,Ren H,Li L,Wang H,Jose PA,Xu Z,Zeng C
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sun Nov 01 00:00:00 EDT 2020
Tissue-engineered human embryonic stem cell-containing cardiac patches: evaluating recellularization of decellularized matrix.
Journal of tissue engineering
Hochman-Mendez C,Pereira de Campos DB,Pinto RS,Mendes BJDS,Rocha GM,Monnerat G,Weissmuller G,Sampaio LC,Carvalho AB,Taylor DA,de Carvalho ACC
MA5-12960 was used in Flow cytometry/Cell sorting to describe a unique combination of biochemical, biomechanical, histological, and physiological parameters for quantifying recellularization efficiency of tissue-engineered cardiac patches compared with native cardiac tissue.
Mon Sep 28 00:00:00 EDT 2020
An Aurora Kinase B-Based Mouse System to Efficiently Identify and Analyze Proliferating Cardiomyocytes.
Frontiers in cell and developmental biology
Fu W,Liao Q,Li L,Shi Y,Zeng A,Zeng C,Wang WE
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry (PFA fixed)
Fri Oct 30 00:00:00 EDT 2020
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells.
Stem cells (Dayton, Ohio)
Liang W,Han P,Kim EH,Mak J,Zhang R,Torrente AG,Goldhaber JI,Marbán E,Cho HC
MA5-12960 was used in Flow Cytometry to investigate the mechanisms for nodal pacemaker cell commitment.
Sun Mar 01 00:00:00 EST 2020
Misoprostol attenuates neonatal cardiomyocyte proliferation through Bnip3, perinuclear calcium signaling, and inhibition of glycolysis.
Journal of molecular and cellular cardiology
Martens MD,Field JT,Seshadri N,Day C,Chapman D,Keijzer R,Doucette CA,Hatch GM,West AR,Ivanco TL,Gordon JW
MA5-12960 was used in Immunocytochemistry-immunoflourescence to demonstrate how hypoxia-induced neonatal cardiomyocyte proliferation can be modulated using misoprostol treatment.
Tue Sep 01 00:00:00 EDT 2020
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity.
Toxicology and applied pharmacology
Miller JM,Meki MH,Ou Q,George SA,Gams A,Abouleisa RRE,Tang XL,Ahern BM,Giridharan GA,El-Baz A,Hill BG,Satin J,Conklin DJ,Moslehi J,Bolli R,Ribeiro AJS,Efimov IR,Mohamed TMA
MA5-12960 was used in Immunocytochemistry to indicate that heart slice culture models have the potential to become a reliable platform for testing and elucidating mechanisms of drug cardiotoxicity.
Sun Nov 01 00:00:00 EDT 2020
Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing.
Stem cell research
Merkert S,Jaboreck MC,Engels L,Malik MNH,Göhring G,Pessler F,Martin U,Olmer R
MA5-12960 was used in Immunocytochemistry, Flow Cytometry to generate ISG15 knockout clones from human iPSCs, which provide useful cell resources to study mechanisms of ISG15 deficiency and gain more insight into the biological function of ISG15.
Tue Dec 22 00:00:00 EST 2020
Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing.
Stem cell research
Merkert S,Jaboreck MC,Engels L,Malik MNH,Göhring G,Pessler F,Martin U,Olmer R
MA5-12960 was used in Immunocytochemistry, Flow Cytometry to generate ISG15 knockout clones from human iPSCs, which provide useful cell resources to study mechanisms of ISG15 deficiency and gain more insight into the biological function of ISG15.
Tue Dec 22 00:00:00 EST 2020
Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart.
Genes
Lee S,Hesse R,Tamaki S,Garland C,Pomerantz JH
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Thu Jun 18 00:00:00 EDT 2020
Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart.
Genes
Lee S,Hesse R,Tamaki S,Garland C,Pomerantz JH
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Thu Jun 18 00:00:00 EDT 2020
Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling.
MethodsX
Aalders J,Léger L,Tuerlings T,Ledda S,van Hengel J
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sat Oct 03 00:00:00 EDT 2020
Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling.
MethodsX
Aalders J,Léger L,Tuerlings T,Ledda S,van Hengel J
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Sat Oct 03 00:00:00 EDT 2020
Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes.
Scientific reports
Testa G,Russo M,Di Benedetto G,Barbato M,Parisi S,Pirozzi F,Tocchetti CG,Abete P,Bonaduce D,Russo T,Passaro F
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Apr 28 00:00:00 EDT 2020
Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes.
Scientific reports
Testa G,Russo M,Di Benedetto G,Barbato M,Parisi S,Pirozzi F,Tocchetti CG,Abete P,Bonaduce D,Russo T,Passaro F
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Apr 28 00:00:00 EDT 2020
Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution.
Cell reports
Wang Z,Cui M,Shah AM,Tan W,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Dec 08 00:00:00 EST 2020
Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution.
Cell reports
Wang Z,Cui M,Shah AM,Tan W,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Tue Dec 08 00:00:00 EST 2020
Differences in Mitochondrial Membrane Potential Identify Distinct Populations of Human Cardiac Mesenchymal Progenitor Cells.
International journal of molecular sciences
Gambini E,Martinelli I,Stadiotti I,Vinci MC,Scopece A,Eramo L,Sommariva E,Resta J,Benaouadi S,Cogliati E,Paolin A,Parini A,Pompilio G,Savagner F
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Western Blot
Sat Oct 10 00:00:00 EDT 2020
Differences in Mitochondrial Membrane Potential Identify Distinct Populations of Human Cardiac Mesenchymal Progenitor Cells.
International journal of molecular sciences
Gambini E,Martinelli I,Stadiotti I,Vinci MC,Scopece A,Eramo L,Sommariva E,Resta J,Benaouadi S,Cogliati E,Paolin A,Parini A,Pompilio G,Savagner F
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Western Blot
Sat Oct 10 00:00:00 EDT 2020
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Cell stress
Zhao JF,Rodger CE,Allen GFG,Weidlich S,Ganley IG
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Wed Mar 04 00:00:00 EST 2020
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Cell stress
Zhao JF,Rodger CE,Allen GFG,Weidlich S,Ganley IG
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Wed Mar 04 00:00:00 EST 2020
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Cell stress
Zhao JF,Rodger CE,Allen GFG,Weidlich S,Ganley IG
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Wed Mar 04 00:00:00 EST 2020
NOTCH1 is critical for fibroblast-mediated induction of cardiomyocyte specialization into ventricular conduction system-like cells in vitro.
Scientific reports
Ribeiro da Silva A,Neri EA,Turaça LT,Dariolli R,Fonseca-Alaniz MH,Santos-Miranda A,Roman-Campos D,Venturini G,Krieger JE
MA5-12960 was used in Immunocytochemistry-immunoflourescence to develop culture models of rat cardiac cells to assess the role of cardiac fibroblasts on myocytes.
Wed Sep 30 00:00:00 EDT 2020
NOTCH1 is critical for fibroblast-mediated induction of cardiomyocyte specialization into ventricular conduction system-like cells in vitro.
Scientific reports
Ribeiro da Silva A,Neri EA,Turaça LT,Dariolli R,Fonseca-Alaniz MH,Santos-Miranda A,Roman-Campos D,Venturini G,Krieger JE
MA5-12960 was used in Immunocytochemistry-immunoflourescence to develop culture models of rat cardiac cells to assess the role of cardiac fibroblasts on myocytes.
Wed Sep 30 00:00:00 EDT 2020
Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells.
Communications biology
Rohani L,Borys BS,Razian G,Naghsh P,Liu S,Johnson AA,Machiraju P,Holland H,Lewis IA,Groves RA,Toms D,Gordon PMK,Li JW,So T,Dang T,Kallos MS,Rancourt DE
MA5-12960 was used in Immunocytochemistry-immunoflourescence to investigate if conversion of hPSCs, from the conventional "primed" pluripotent state towards the "naïve" state prevalent in mPSCs, could be used to enhance hPSC production.
Mon Sep 07 00:00:00 EDT 2020
Heart-derived fibroblasts express LYPD-1 and negatively regulate angiogenesis in rat.
Regenerative therapy
Sakamoto S,Matsuura K,Masuda S,Hagiwara N,Shimizu T
MA5-12960 was used in Immunocytochemistry to study the anti-angiogenic effect of LYPD-1 expression with neonatal and adult rat heart fibroblasts.
Tue Dec 01 00:00:00 EST 2020
Co-culture of induced pluripotent stem cells with cardiomyocytes is sufficient to promote their differentiation into cardiomyocytes.
PloS one
Chu AJ,Zhao EJ,Chiao M,Lim CJ
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2020
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Cell reports
Feyen DAM,McKeithan WL,Bruyneel AAN,Spiering S,Hörmann L,Ulmer B,Zhang H,Briganti F,Schweizer M,Hegyi B,Liao Z,Pölönen RP,Ginsburg KS,Lam CK,Serrano R,Wahlquist C,Kreymerman A,Vu M,Amatya PL,Behrens CS,Ranjbarvaziri S,Maas RGC,Greenhaw M,Bernstein D,Wu JC,Bers DM,Eschenhagen T,Metallo CM,Mercola M
MA5-12960 was used in Western Blotting to describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs.
Tue Jul 21 00:00:00 EDT 2020
Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes.
STAR protocols
Kleinsorge M,Cyganek L
MA5-12960 was used in Immunocytochemistry to describe a simple, robust, and efficient monolayer-based differentiation of hiPSCs into defined atrial and ventricular cardiomyocytes.
Fri Jun 19 00:00:00 EDT 2020
Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors.
Molecular therapy. Methods & clinical development
Kraszewska I,Tomczyk M,Andrysiak K,Biniecka M,Geisler A,Fechner H,Zembala M,Stępniewski J,Dulak J,Jaźwa-Kusior A
MA5-12960 was used in Flow Cytometry to generate miRNA-122- and miRNA-206-regulated AAV9 vector for a therapeutic, heart-specific overexpression of heme oxygenase-1 (HO-1).
Fri Jun 12 00:00:00 EDT 2020
Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations.
Cancers
Royer-Pokora B,Busch MA,Tenbusch S,Schmidt M,Beier M,Woods AD,Thiele H,Mora J
MA5-12960 was used in Immunocytochemistry-immunoflourescence to represent an important new tool to study WT1 mutant Wilms tumors, potentially leading to new treatment approaches.
Mon Dec 28 00:00:00 EST 2020
Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
Cell stem cell
Hashimoto H,Wang Z,Garry GA,Malladi VS,Botten GA,Ye W,Zhou H,Osterwalder M,Dickel DE,Visel A,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Wed Jul 03 00:00:00 EDT 2019
Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
Cell stem cell
Hashimoto H,Wang Z,Garry GA,Malladi VS,Botten GA,Ye W,Zhou H,Osterwalder M,Dickel DE,Visel A,Liu N,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Wed Jul 03 00:00:00 EDT 2019
Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues.
Cardiovascular research
Guilbeau-Frugier C,Cauquil M,Karsenty C,Lairez O,Dambrin C,Payré B,Cassard H,Josse C,Seguelas MH,Allart S,Branchereau M,Heymes C,Mandel F,Delisle MB,Pathak A,Dague E,Sénard JM,Galés C
MA5-12960 was used in Immunohistochemistry-immunofluorescence to provide evidence for the existence of differential cardiomyocyte surface crests in the cardiac tissue as well as the existence of CM-CM direct physical contacts at their lateral face through crest-crest interactions.
Wed May 01 00:00:00 EDT 2019
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
Cell systems
Wang H,Sheehan RP,Palmer AC,Everley RA,Boswell SA,Ron-Harel N,Ringel AE,Holton KM,Jacobson CA,Erickson AR,Maliszewski L,Haigis MC,Sorger PK
MA5-12960 was used in Immunocytochemistry-immunoflourescence to show anti-cancer tyrosine kinase inhibitors induce adaptive responses in human cardiomyocytes similar to drug resistant tumours.
Wed May 22 00:00:00 EDT 2019
Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.
The Journal of cell biology
Bertero A,Fields PA,Smith AST,Leonard A,Beussman K,Sniadecki NJ,Kim DH,Tse HF,Pabon L,Shendure J,Noble WS,Murry CE
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Mon Sep 02 00:00:00 EDT 2019
Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis.
Acta pharmacologica Sinica
Liao Q,Qu S,Tang LX,Li LP,He DF,Zeng CY,Wang WE
MA5-12960 was used in Immunocytochemistry-Immunofluorescence to study the underlying mechanism and effects of myokine irisin on an acute myocardial infarction mouse model.
Tue Oct 01 00:00:00 EDT 2019
miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart.
Stem cells international
Xuan W,Wang L,Xu M,Weintraub NL,Ashraf M
MA5-12960 was used in Immunohistochemistry to report that extracellular vesicles (EV) secreted by ISX-9-induced CPCs (EV-CPCISX-9) faithfully recapitulate the beneficial effects of their parent CPCs with regard to postinfarction remodeling.
Sat Sep 24 00:00:00 EDT 2022
Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner.
American journal of physiology. Heart and circulatory physiology
Durham KK,Kluck G,Mak KC,Deng YD,Trigatti BL
MA5-12960 was used in Immunohistochemistry to demonstrate that SR-B1 deficiency increases the sensitivity of mice with endogenously expressed ApoA1 to DOX-induced myocardial apoptosis.
Sat Jun 01 00:00:00 EDT 2019
Long-Term Engraftment of Human Cardiomyocytes Combined with Biodegradable Microparticles Induces Heart Repair.
The Journal of pharmacology and experimental therapeutics
Saludas L,Garbayo E,Mazo M,Pelacho B,Abizanda G,Iglesias-Garcia O,Raya A,Prósper F,Blanco-Prieto MJ
MA5-12960 was used in Flow cytometry/Cell sorting to explore the potential for biodegradable microparticles as a platform for delivery of therapeutic human cardiomyocytes intended for cardiac repair.
Sun Sep 01 00:00:00 EDT 2019
Generation of human iPS cell line CBTCi001-A from dermal fibroblasts obtained from a healthy donor.
Stem cell research
Martins GLS,Paredes BD,Sampaio GLA,Nonaka CKV,da Silva KN,Allahdadi KJ,França LSA,Soares MBP,Dos Santos RR,Souza BSF
MA5-12960 was used in Immunocytochemistry, Flow Cytometry to show that expression of typical markers of pluripotency and differentiation potential in vitro.
Sun Dec 01 00:00:00 EST 2019
Generation of human iPS cell line CBTCi001-A from dermal fibroblasts obtained from a healthy donor.
Stem cell research
Martins GLS,Paredes BD,Sampaio GLA,Nonaka CKV,da Silva KN,Allahdadi KJ,França LSA,Soares MBP,Dos Santos RR,Souza BSF
MA5-12960 was used in Immunocytochemistry, Flow Cytometry to show that expression of typical markers of pluripotency and differentiation potential in vitro.
Sun Dec 01 00:00:00 EST 2019
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.
Stem cell research
Mura M,Lee YK,Pisano F,Ginevrino M,Boni M,Calabrò F,Crotti L,Valente EM,Schwartz PJ,Tse HF,Gnecchi M
MA5-12960 was used in Immunocytochemistry to generate human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene.
Wed May 01 00:00:00 EDT 2019
Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues.
Stem cell research & therapy
Murphy JF,Mayourian J,Stillitano F,Munawar S,Broughton KM,Agullo-Pascual E,Sussman MA,Hajjar RJ,Costa KD,Turnbull IC
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Wed Dec 04 00:00:00 EST 2019
A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
eLife
Ward MC,Gilad Y
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunofluorescence
Mon Apr 08 00:00:00 EDT 2019
A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
eLife
Ward MC,Gilad Y
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunofluorescence
Mon Apr 08 00:00:00 EDT 2019
The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.
The Journal of biological chemistry
Francisco J,Byun J,Zhang Y,Kalloo OB,Mizushima W,Oka S,Zhai P,Sadoshima J,Del Re DP
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, ELISA to indicate that myeloid RASSF1A antagonizes I/R-induced myocardial inflammation and suggest that RASSF1A may be a promising target in immunomodulatory therapy for the management of acute heart injury.
Fri Aug 30 00:00:00 EDT 2019
Multifactorial Modeling Reveals a Dominant Role of Wnt Signaling in Lineage Commitment of Human Pluripotent Stem Cells.
Bioengineering (Basel, Switzerland)
Dias TP,Fernandes TG,Diogo MM,Cabral JMS
MA5-12960 was used in Flow cytometry/Cell sorting to predict a dominant role of Wnt signaling over FGF and TGF signaling in a dry-signaling culture system using a multifactorial, multiparameter modeling approach.
Thu Aug 15 00:00:00 EDT 2019
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction.
Nature communications
Park SJ,Kim RY,Park BW,Lee S,Choi SW,Park JH,Choi JJ,Kim SW,Jang J,Cho DW,Chung HM,Moon SH,Ban K,Park HJ
MA5-12960 was used in Immunohistochemistry to provide a dual stem cell therapy approach to enhance cardiac repair on myocardial infarction hearts.
Tue Jul 16 00:00:00 EDT 2019
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction.
Nature communications
Park SJ,Kim RY,Park BW,Lee S,Choi SW,Park JH,Choi JJ,Kim SW,Jang J,Cho DW,Chung HM,Moon SH,Ban K,Park HJ
MA5-12960 was used in Immunohistochemistry to provide a dual stem cell therapy approach to enhance cardiac repair on myocardial infarction hearts.
Tue Jul 16 00:00:00 EDT 2019
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction.
Nature communications
Park SJ,Kim RY,Park BW,Lee S,Choi SW,Park JH,Choi JJ,Kim SW,Jang J,Cho DW,Chung HM,Moon SH,Ban K,Park HJ
MA5-12960 was used in Immunohistochemistry to provide a dual stem cell therapy approach to enhance cardiac repair on myocardial infarction hearts.
Tue Jul 16 00:00:00 EDT 2019
Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming.
Scientific reports
Zhang Z,Zhang W,Nam YJ
MA5-12960 was used in Flow cytometry/Cell sorting to demonstrate the stoichiometric requirement of GHMT expression for structural and functional progresses of cardiomyocyte reprogramming.
Fri Oct 18 00:00:00 EDT 2019
Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.
Cell
Mohamed TMA,Ang YS,Radzinsky E,Zhou P,Huang Y,Elfenbein A,Foley A,Magnitsky S,Srivastava D
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunofluorescence
Thu Mar 22 00:00:00 EDT 2018
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
Cell stem cell
Friedman CE,Nguyen Q,Lukowski SW,Helfer A,Chiu HS,Miklas J,Levy S,Suo S,Han JJ,Osteil P,Peng G,Jing N,Baillie GJ,Senabouth A,Christ AN,Bruxner TJ,Murry CE,Wong ES,Ding J,Wang Y,Hudson J,Ruohola-Baker H,Bar-Joseph Z,Tam PPL,Powell JE,Palpant NJ
MA5-12960 was used in Flow cytometry/Cell sorting to provide a key transcriptional roadmap of in vitro cardiac differentiation at single-cell resolution, revealing fundamental mechanisms underlying heart development and differentiation of hPSC-derived cardiomyocytes.
Thu Oct 04 00:00:00 EDT 2018
Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Nakashima Y,Miyagi-Shiohira C,Noguchi H,Omasa T
MA5-12960 was used in Immunocytochemistry-immunoflourescence to suggest that the addition of atorvastatin to hiPSC cultures reduces the survival of pluripotent cells by suppressing the HIF1α-PPAR axis.
Thu Jul 05 00:00:00 EDT 2018
Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity.
Stem cells international
Du G,Yu M,Wang L,Hu W,Song L,Lu C,Wang X
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Oct 01 00:00:00 EDT 2020
High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2.
The Biochemical journal
Durham KK,Chathely KM,Trigatti BL
MA5-12960 was used in Immunocytochemistry-immunoflourescence to identify a role of SR-B1 in mediating the protective effects of HDL against necrosis in cardiomyocytes, and to identify AKT activation downstream of SR-B1 in cardiomyocytes.
Thu Apr 05 00:00:00 EDT 2018
Endocardial Hippo signaling regulates myocardial growth and cardiogenesis.
Developmental biology
Artap S,Manderfield LJ,Smith CL,Poleshko A,Aghajanian H,See K,Li L,Jain R,Epstein JA
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Wed Aug 01 00:00:00 EDT 2018
Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.
International heart journal
Sakai T,Naito AT,Kuramoto Y,Ito M,Okada K,Higo T,Nakagawa A,Shibamoto M,Yamaguchi T,Sumida T,Nomura S,Umezawa A,Miyagawa S,Sawa Y,Morita H,Lee JK,Shiojima I,Sakata Y,Komuro I
MA5-12960 was used in Immunocytochemistry-immunoflourescence to study the pathophysiology of infantile hypertrophic cardiomyopathy.
Wed Sep 26 00:00:00 EDT 2018
Low-temperature culturing improves survival rate of tissue-engineered cardiac cell sheets.
Biochemistry and biophysics reports
Sakaguchi K,Hinata Y,Kagawa Y,Iwasaki K,Tsuneda S,Shimizu T,Umezu M
MA5-12960 was used in Immunohistochemistry-immunofluorescence to indicate that the low-temperature process is effective for fabricating 3D tissues from high-functioning cells such as heart cells.
Sun Jul 01 00:00:00 EDT 2018
HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.
American journal of physiology. Heart and circulatory physiology
Durham KK,Chathely KM,Mak KC,Momen A,Thomas CT,Zhao YY,MacDonald ME,Curtis JM,Husain M,Trigatti BL
MA5-12960 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to assess whether increased HDL levels protect against doxorubicin-induced cardiotoxicity in vivo and in cardiomyocytes in culture and explored the intracellular signaling mechanisms involved, particularly the role of SR-B1.
Mon Jan 01 00:00:00 EST 2018
The microRNA regulatory landscape of MSC-derived exosomes: a systems view.
Scientific reports
Ferguson SW,Wang J,Lee CJ,Liu M,Neelamegham S,Canty JM,Nguyen J
MA5-12960 was used in Immunocytochemistry-immunoflourescence to study the molecular mechanisms and miRNA complement underlying mesenchymal stem cell exosomes.
Tue Jan 23 00:00:00 EST 2018
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene.
Stem cell research
Mura M,Lee YK,Ginevrino M,Zappatore R,Pisano F,Boni M,Dagradi F,Crotti L,Valente EM,Schwartz PJ,Tse HF,Gnecchi M
MA5-12960 was used in Immunocytochemistry to report the generation of human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a female patient carrier of the two compound heterozygous mutations c.568 C>T p.R190W (maternal allele), and c.1781 G>A p.R594Q.
Tue May 01 00:00:00 EDT 2018
Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.
Nature biotechnology
Protze SI,Liu J,Nussinovitch U,Ohana L,Backx PH,Gepstein L,Keller GM
MA512960 was used in flow cytometry and immunohistochemistry - frozen section to describe a protocol to generate sinoatrial node-like pacemaker cells
Sun Jan 01 00:00:00 EST 2017
Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells.
Nature protocols
Palpant NJ,Pabon L,Friedman CE,Roberts M,Hadland B,Zaunbrecher RJ,Bernstein I,Zheng Y,Murry CE
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.
Genes & development
Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Fri Sep 01 00:00:00 EDT 2017
ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.
Genes & development
Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Fri Sep 01 00:00:00 EDT 2017
Circadian networks in human embryonic stem cell-derived cardiomyocytes.
EMBO reports
Dierickx P,Vermunt MW,Muraro MJ,Creyghton MP,Doevendans PA,van Oudenaarden A,Geijsen N,Van Laake LW
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Circadian networks in human embryonic stem cell-derived cardiomyocytes.
EMBO reports
Dierickx P,Vermunt MW,Muraro MJ,Creyghton MP,Doevendans PA,van Oudenaarden A,Geijsen N,Van Laake LW
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3',5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Frontiers in endocrinology
Lin B,Lin X,Stachel M,Wang E,Luo Y,Lader J,Sun X,Delmar M,Bu L
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Wed Aug 09 00:00:00 EDT 2023
Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhou L,Dai H,Wu J,Zhou M,Yuan H,Du J,Yang L,Wu X,Xu H,Hua Y,Xu J,Zheng L,Shen B
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sun Jan 01 00:00:00 EST 2017
Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhou L,Dai H,Wu J,Zhou M,Yuan H,Du J,Yang L,Wu X,Xu H,Hua Y,Xu J,Zheng L,Shen B
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunohistochemistry
Sun Jan 01 00:00:00 EST 2017
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity.
Stem cell reports
Abad M,Hashimoto H,Zhou H,Morales MG,Chen B,Bassel-Duby R,Olson EN
MA512960 was used in immunocytochemistry to test the ability of the Notch inhibitor DAPT to convert murine fibroblasts into cardiomyocytes
Tue Mar 14 00:00:00 EDT 2017
Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells.
Scientific reports
Hong SP,Song S,Cho SW,Lee S,Koh BI,Bae H,Kim KH,Park JS,Do HS,Im I,Heo HJ,Ko TH,Park JH,Youm JB,Kim SJ,Kim I,Han J,Han YM,Koh GY
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Mon Feb 06 00:00:00 EST 2017
MED12 regulates a transcriptional network of calcium-handling genes in the heart.
JCI insight
Baskin KK,Makarewich CA,DeLeon SM,Ye W,Chen B,Beetz N,Schrewe H,Bassel-Duby R,Olson EN
MA5-12960 was used in Immunohistochemistry to reveal, using a mouse model, the function of MED12 in the heart.
Thu Jul 20 00:00:00 EDT 2017
Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.
PloS one
Miake J,Notsu T,Higaki K,Hidaka K,Morisaki T,Yamamoto K,Hisatome I
MA5-12960 was used in Immunocytochemistry-immunoflourescence to investigate the expression patterns and functional roles of the Cited4 gene during in vitro cardiogenesis.
Mon Oct 16 00:00:00 EDT 2017
A transcribed enhancer dictates mesendoderm specification in pluripotency.
Nature communications
Alexanian M,Maric D,Jenkinson SP,Mina M,Friedman CE,Ting CC,Micheletti R,Plaisance I,Nemir M,Maison D,Kernen J,Pezzuto I,Villeneuve D,Burdet F,Ibberson M,Leib SL,Palpant NJ,Hernandez N,Ounzain S,Pedrazzini T
MA5-12960 was used in Flow cytometry/Cell sorting to evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification.
Mon Nov 27 00:00:00 EST 2017
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Nature medicine
Burridge PW,Li YF,Matsa E,Wu H,Ong SG,Sharma A,Holmström A,Chang AC,Coronado MJ,Ebert AD,Knowles JW,Telli ML,Witteles RM,Blau HM,Bernstein D,Altman RB,Wu JC
MA5-12960 was used in immunocytochemistry to study the recapitulation of the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity due to human induced pluripotent stem cell-derived cardiomyocytes
Sun May 01 00:00:00 EDT 2016
Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.
Cell
Ang YS,Rivas RN,Ribeiro AJS,Srivas R,Rivera J,Stone NR,Pratt K,Mohamed TMA,Fu JD,Spencer CI,Tippens ND,Li M,Narasimha A,Radzinsky E,Moon-Grady AJ,Yu H,Pruitt BL,Snyder MP,Srivastava D
MA512960 was used in flow cytometry and immunocytochemistry to demonstrate that iPS-derived cardiomyocytes with a heterozygous GATA4-G296S missense mutation show impaired contractility, calcium handling, and metabolic activity
Thu Dec 15 00:00:00 EST 2016
Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons.
Cell stem cell
Oh Y,Cho GS,Li Z,Hong I,Zhu R,Kim MJ,Kim YJ,Tampakakis E,Tung L,Huganir R,Dong X,Kwon C,Lee G
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunocytochemistry
Thu Jul 07 00:00:00 EDT 2016
Poly(Limonene Thioether) Scaffold for Tissue Engineering.
Advanced healthcare materials
Fischer KM,Morgan KY,Hearon K,Sklaviadis D,Tochka ZL,Fenton OS,Anderson DG,Langer R,Freed LE
MA5-12960 was used in immunocytochemistry to study tissue engineering and poly(limonene thioether) scaffold
Wed Apr 06 00:00:00 EDT 2016
Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration.
The Journal of cell biology
Chiapparo G,Lin X,Lescroart F,Chabab S,Paulissen C,Pitisci L,Bondue A,Blanpain C
MA5-12960 was used in immunocytochemistry to investigate the contribution of Mesp1 in cardiovascular progenitor specification and cell migration
Mon May 23 00:00:00 EDT 2016
Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice.
Development, growth & differentiation
Nakamura R,Koshiba-Takeuchi K,Tsuchiya M,Kojima M,Miyazawa A,Ito K,Ogawa H,Takeuchi JK
MA512960 was used in immunohistochemistry - paraffin section to propose that Baf60c plays contributes to heart development and regeneration in young mice
Sun May 01 00:00:00 EDT 2016
Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene.
Biology open
Fuchs C,Gawlas S,Heher P,Nikouli S,Paar H,Ivankovic M,Schultheis M,Klammer J,Gottschamel T,Capetanaki Y,Weitzer G
MA5-12960 was used in immunocytochemistry to study modulation of Nkx2.5 expression by participating in transcription factor complexes that interact with nkx2.5 after desmin enters the nucleus of cardiac stem cells
Tue Jan 19 00:00:00 EST 2016
Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays.
Scientific reports
Titmarsh DM,Glass NR,Mills RJ,Hidalgo A,Wolvetang EJ,Porrello ER,Hudson JE,Cooper-White JJ
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays.
Scientific reports
Titmarsh DM,Glass NR,Mills RJ,Hidalgo A,Wolvetang EJ,Porrello ER,Hudson JE,Cooper-White JJ
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.
Stem cell reports
Josowitz R,Mulero-Navarro S,Rodriguez NA,Falce C,Cohen N,Ullian EM,Weiss LA,Rauen KA,Sobie EA,Gelb BD
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Tue Sep 13 00:00:00 EDT 2016
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.
Stem cell reports
Josowitz R,Mulero-Navarro S,Rodriguez NA,Falce C,Cohen N,Ullian EM,Weiss LA,Rauen KA,Sobie EA,Gelb BD
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Tue Sep 13 00:00:00 EDT 2016
Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.
Cell reports
Passer D,van de Vrugt A,Atmanli A,Domian IJ
MA5-12960 was used in immunohistochemistry - frozen section to elucidate the requirement for atypical protein kinase c-dependent polarized cell division in myocardial trabeculation
Tue Feb 23 00:00:00 EST 2016
Postnatal Development of Right Ventricular Myofibrillar Biomechanics in Relation to the Sarcomeric Protein Phenotype in Pediatric Patients with Conotruncal Heart Defects.
Journal of the American Heart Association
Elhamine F,Iorga B,Krüger M,Hunger M,Eckhardt J,Sreeram N,Bennink G,Brockmeier K,Pfitzer G,Stehle R
MA5-12960 was used in western blot to characterize the sarcomeric protein phenotype in relation to postnatal development of right ventricular myofibrillar biomechanics in pediatric patients with conotruncal heart defects
Mon Jun 27 00:00:00 EDT 2016
Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome.
Scientific reports
Okata S,Yuasa S,Suzuki T,Ito S,Makita N,Yoshida T,Li M,Kurokawa J,Seki T,Egashira T,Aizawa Y,Kodaira M,Motoda C,Yozu G,Shimojima M,Hayashiji N,Hashimoto H,Kuroda Y,Tanaka A,Murata M,Aiba T,Shimizu W,Horie M,Kamiya K,Furukawa T,Fukuda K
MA5-12960 was used in immunocytochemistry study the timing of disease manifestation for Brugada syndrome
Wed Sep 28 00:00:00 EDT 2016
Simple Monolayer Differentiation of Murine Cardiomyocytes via Nutrient Deprivation-Mediated Activation of β-Catenin.
Stem cell reviews and reports
Hofbauer P,Jung JP,McArdle TJ,Ogle BM
MA512960 was used in immunocytochemistry to optimize the generation of murine cardiomyocytes from pluripotent stem cells
Thu Dec 01 00:00:00 EST 2016
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.
Nature communications
Eng G,Lee BW,Protas L,Gagliardi M,Brown K,Kass RS,Keller G,Robinson RB,Vunjak-Novakovic G
MA5-12960 was used in flow cytometry to determine the autonomouse beating rate adaptation in cardiomyocytes from human stem cells
Tue Jan 19 00:00:00 EST 2016
Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
Methods in molecular biology (Clifton, N.J.)
van den Berg CW,Elliott DA,Braam SR,Mummery CL,Davis RP
MA5-12960 was used in flow cytometry to develop protocol for cardiomyocytes differentiation from human pluripotent stem cells
Thu Aug 18 00:00:00 EDT 2016
Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.
Nature communications
Langer D,Martianov I,Alpern D,Rhinn M,Keime C,Dollé P,Mengus G,Davidson I
MA5-12960 was used in immunocytochemistry to determine that a core TFIID TATA-binding protein-associated factor is essential in differentiation events during mammalian embryogenesis
Wed Mar 30 00:00:00 EDT 2016
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells.
Nature communications
Kempf H,Olmer R,Haase A,Franke A,Bolesani E,Schwanke K,Robles-Diaz D,Coffee M,Göhring G,Dräger G,Pötz O,Joos T,Martinez-Hackert E,Haverich A,Buettner FFR,Martin U,Zweigerdt R
MA512960 was used in flow cytometry to report that cell density deterministically alters anteroposterior patterning of primitive streak-like priming
Fri Dec 09 00:00:00 EST 2016
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Nature
Kimura W,Xiao F,Canseco DC,Muralidhar S,Thet S,Zhang HM,Abderrahman Y,Chen R,Garcia JA,Shelton JM,Richardson JA,Ashour AM,Asaithamby A,Liang H,Xing C,Lu Z,Zhang CC,Sadek HA
MA5-12960 was used in immunohistochemistry - frozen section to report fate mapping of hypoxic cells in the heart using transgenic mice.
Thu Jul 09 00:00:00 EDT 2015
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
EMBO molecular medicine
Clarke JR,Lyra E Silva NM,Figueiredo CP,Frozza RL,Ledo JH,Beckman D,Katashima CK,Razolli D,Carvalho BM,Frazão R,Silveira MA,Ribeiro FC,Bomfim TR,Neves FS,Klein WL,Medeiros R,LaFerla FM,Carvalheira JB,Saad MJ,Munoz DP,Velloso LA,Ferreira ST,De Felice FG
MA5-12960 was used in immunohistochemistry - paraffin section and western blot to characterize how peripheral metabolic deregulation is induced by Alzheimer-associated A-beta oligomers that impact the central nervous system
Sun Feb 01 00:00:00 EST 2015
Brg1 modulates enhancer activation in mesoderm lineage commitment.
Development (Cambridge, England)
Alexander JM,Hota SK,He D,Thomas S,Ho L,Pennacchio LA,Bruneau BG
MA5-12960 was used in western blot to report that Brg1 is required for enhancer activation in mesoderm induction.
Wed Apr 15 00:00:00 EDT 2015
A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes.
Frontiers in cell and developmental biology
Jones AR,Edwards DH,Cummins MJ,Williams AJ,George CH
MA5-12960 was used in Immunocytochemistry to investigate the effect of maturation in embryoid bodies (EB) vs. "on plate" culture on spontaneous activity and regional Ca(2+) synchronization in IPS-CM clusters.
Thu Jan 21 00:00:00 EST 2016
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling.
Stem cell reports
Tsai SY,Maass K,Lu J,Fishman GI,Chen S,Evans T
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunofluorescence
Tue Jun 09 00:00:00 EDT 2015
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling.
Stem cell reports
Tsai SY,Maass K,Lu J,Fishman GI,Chen S,Evans T
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Immunofluorescence
Tue Jun 09 00:00:00 EDT 2015
Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion.
Nature protocols
Zhu S,Wang H,Ding S
MA5-12960 was used in immunocytochemistry to develop techniques to generate cardiomyocytes, neural stem cells, and hepatocytes from fibroblasts
Wed Jul 01 00:00:00 EDT 2015
An integrated statistical model for enhanced murine cardiomyocyte differentiation via optimized engagement of 3D extracellular matrices.
Scientific reports
Jung JP,Hu D,Domian IJ,Ogle BM
MA5-12960 was used in immunocytochemistry to study a 3D extracellulalr matrix as an integrated statistical model for enhanced murine cardiomyocyte differentiation
Mon Dec 21 00:00:00 EST 2015
Cyclosporin A induces cardiac differentiation but inhibits hemato-endothelial differentiation of P19 cells.
PloS one
Choi SC,Lee H,Choi JH,Kim JH,Park CY,Joo HJ,Park JH,Hong SJ,Yu CW,Lim DS
MA5-12960 was used in immunocytochemistry to examine the effects of cyclosporin A on the fate of stem cells and cardiomyogenic differentiation
Thu Feb 04 00:00:00 EST 2016
PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart.
PloS one
Quan C,Xie B,Wang HY,Chen S
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Western Blot
Mon Feb 08 00:00:00 EST 2016
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
PloS one
Kim MS,Horst A,Blinka S,Stamm K,Mahnke D,Schuman J,Gundry R,Tomita-Mitchell A,Lough J
MA5-12960 was used in flow cytometry to examine the effects of CHIR inductionin in stem cells to determine if it enhances development of the cardiomyogenic lineage
Thu Dec 03 00:00:00 EST 2015
Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes.
PloS one
Palpant NJ,Hofsteen P,Pabon L,Reinecke H,Murry CE
MA5-12960 was used in immunocytochemistry to characterize zebrafish and human embryonic stem cells and inhibition of cardiac development with exposure to e-cigarettes and tobacco cigarettes
Mon Apr 18 00:00:00 EDT 2016
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.
Genome biology
Szabo L,Morey R,Palpant NJ,Wang PL,Afari N,Jiang C,Parast MM,Murry CE,Laurent LC,Salzman J
MA5-12960 was used in flow cytometry to discuss methods to study the function of circular RNA.
Tue Jun 16 00:00:00 EDT 2015
Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4.
Stem cell reports
Ban K,Wile B,Cho KW,Kim S,Song MK,Kim SY,Singer J,Syed A,Yu SP,Wagner M,Bao G,Yoon YS
MA5-12960 was used in flow cytometry and immunocytochemistry to study differentiating embryonic stem cells through molecular beacons targeting IRX-4 after non-genetic purification of ventricular cardiomyocytes
Tue Dec 08 00:00:00 EST 2015
An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis.
PloS one
Busser BW,Lin Y,Yang Y,Zhu J,Chen G,Michelson AM
MA5-12960 was used in flow cytometry to characterize regulators of cardiogenesis by use of an orthologous epigenetic gene expression signature created from differentiating embryonic stem cells
Tue Jun 07 00:00:00 EDT 2016
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Nature communications
Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K
MA5-12960 was used in flow cytometry and immunocytochemistry to investigate how reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signaling
Thu Sep 10 00:00:00 EDT 2015
A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes.
Journal of biomolecular screening
Lewis KJ,Silvester NC,Barberini-Jammaers S,Mason SA,Marsh SA,Lipka M,George CH
MA5-12960 was used in immunocytochemistry to describe a new analytical framework to profile the amplitude and temporal patterning of intra- and intercellular calcium signals in human stem cell-derived cardiomyocytes
Sun Mar 01 00:00:00 EST 2015
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.
Cell
Puente BN,Kimura W,Muralidhar SA,Moon J,Amatruda JF,Phelps KL,Grinsfelder D,Rothermel BA,Chen R,Garcia JA,Santos CX,Thet S,Mori E,Kinter MT,Rindler PM,Zacchigna S,Mukherjee S,Chen DJ,Mahmoud AI,Giacca M,Rabinovitch PS,Aroumougame A,Shah AM,Szweda LI,Sadek HA
MA5-12960 was used in immunohistochemistry and western blot to study the role of the DNA damage response in the mechanism by which oxygen-rich post-natal conditions induce cardiomyocytes to enter cell cycle arrest
Thu Apr 24 00:00:00 EDT 2014
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
MA5-12960 was used in flow cytometry and immunocytochemistry to analyze the chemical profile of generation of human cardiomyocytes
Fri Aug 01 00:00:00 EDT 2014
PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.
The Journal of clinical investigation
Kim EE,Shekhar A,Lu J,Lin X,Liu FY,Zhang J,Delmar M,Fishman GI
MA5-12960 was used in immunohistochemistry - frozen section to investigate the role of PCP4 in Purkinje cell excitability and cardiac rhythmicity
Sat Nov 01 00:00:00 EDT 2014
Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
Nature protocols
Wile BM,Ban K,Yoon YS,Bao G
MA5-12960 was used in immunocytochemistry to describe how to isolate a specific cell population from differentiating pluripotent stem cells
Wed Oct 01 00:00:00 EDT 2014
Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.
Development (Cambridge, England)
Nam YJ,Lubczyk C,Bhakta M,Zang T,Fernandez-Perez A,McAnally J,Bassel-Duby R,Olson EN,Munshi NV
MA5-12960 was used in immunocytochemistry to characterize the reprogramming of fibroblasts with cardiac transcription factors by induction of diverse cardiac cell types
Sat Nov 01 00:00:00 EDT 2014
Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells.
Stem cells (Dayton, Ohio)
Xie Y,Ibrahim A,Cheng K,Wu Z,Liang W,Malliaras K,Sun B,Liu W,Shen D,Cheol Cho H,Li T,Lu L,Lu G,Marbán E
MA5-12960 was used in flow cytometry to study the role of beta1-integrins in the cell-cell contact dependency of the regenerative effects of cardiosphere-derived cells following myocardial infarction
Mon Sep 01 00:00:00 EDT 2014
Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm.
Stem cells (Dayton, Ohio)
Engels MC,Rajarajan K,Feistritzer R,Sharma A,Nielsen UB,Schalij MJ,de Vries AA,Pijnappels DA,Wu SM
MA5-12960 was used in flow cytometry to study the role of IGF family ligands in mesodermal expansion and promotion of differentiation towards a cardiac lineage
Sun Jun 01 00:00:00 EDT 2014
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Turnbull IC,Karakikes I,Serrao GW,Backeris P,Lee JJ,Xie C,Senyei G,Gordon RE,Li RA,Akar FG,Hajjar RJ,Hulot JS,Costa KD
MA5-12960 was used in immunohistochemistry to evaluate human engineered cardiac tissues
Sat Feb 01 00:00:00 EST 2014
Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development.
Developmental dynamics : an official publication of the American Association of Anatomists
Nelson DO,Jin DX,Downs KM,Kamp TJ,Lyons GE
MA5-12960 was used in immunohistochemistry to study the role of a population of Irx4-positive cells in the development of the ventral myocardium
Sat Mar 01 00:00:00 EST 2014
Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin.
Stem cell research
Mallon BS,Hamilton RS,Kozhich OA,Johnson KR,Fann YC,Rao MS,Robey PG
MA5-12960 was used in immunocytochemistry to study two pluripotent stem cell populations in regards to a neural precurson cell population
Sat Mar 01 00:00:00 EST 2014
Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A.
Stem cell research
Wolchinsky Z,Shivtiel S,Kouwenhoven EN,Putin D,Sprecher E,Zhou H,Rouleau M,Aberdam D
MA5-12960 was used in flow cytometry and immunocytochemistry to investigate the role of angiomodulin in the cardiogenesis of embryonic stem cells
Wed Jan 01 00:00:00 EST 2014
Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.
Journal of the American Heart Association
Cho SW,Park JS,Heo HJ,Park SW,Song S,Kim I,Han YM,Yamashita JK,Youm JB,Han J,Koh GY
MA5-12960 was used in flow cytometry and immunocytochemistry to study the effects of Cyclosporin A -mediated inhibition of the mitochondrial permeability transition pore on the cardiomyocyte differentiation of pluripotent stem cells
Thu Mar 13 00:00:00 EDT 2014
Mutations in Alström protein impair terminal differentiation of cardiomyocytes.
Nature communications
Shenje LT,Andersen P,Halushka MK,Lui C,Fernandez L,Collin GB,Amat-Alarcon N,Meschino W,Cutz E,Chang K,Yonescu R,Batista DA,Chen Y,Chelko S,Crosson JE,Scheel J,Vricella L,Craig BD,Marosy BA,Mohr DW,Hetrick KN,Romm JM,Scott AF,Valle D,Naggert JK,Kwon C,Doheny KF,Judge DP
MA5-12960 was used in flow cytometry to identify proteins involved in postnatal cardiomyocyte cell cycle arrest
Tue Mar 04 00:00:00 EST 2014
Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression.
PloS one
Josowitz R,Lu J,Falce C,D'Souza SL,Wu M,Cohen N,Dubois NC,Zhao Y,Sobie EA,Fishman GI,Gelb BD
Published figure using Cardiac Troponin T monoclonal antibody (Product # MA5-12960) in Flow Cytometry
Tue Mar 03 00:00:00 EST 2015
Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.
PloS one
Kowno M,Watanabe-Susaki K,Ishimine H,Komazaki S,Enomoto K,Seki Y,Wang YY,Ishigaki Y,Ninomiya N,Noguchi TA,Kokubu Y,Ohnishi K,Nakajima Y,Kato K,Intoh A,Takada H,Yamakawa N,Wang PC,Asashima M,Kurisaki A
MA5-12960 was used in immunocytochemistry to study mouse embryonic stem cells in mitochondria and how Prohibitin 2 regulates lineage-specific differentiation and proliferation
Thu Jun 11 00:00:00 EDT 2015
Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function.
Nature communications
Traister A,Li M,Aafaqi S,Lu M,Arab S,Radisic M,Gross G,Guido F,Sherret J,Verma S,Slorach C,Mertens L,Hui W,Roy A,Delgado-Olguín P,Hannigan G,Maynes JT,Coles JG
MA5-12960 was used in Immunohistochemistry to show that integrin-linked kinase (ILK) mediates cardiomyocyte force transduction through regulation of sarcoplasmic/endoplasmic reticulum Ca(2+)ATPase isoform 2a (SERCA-2a) and phosphorylation of phospholamban (PLN) in the human heart.
Thu Sep 11 00:00:00 EDT 2014
Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient-derived cardiomyocytes.
Molecular therapy. Methods & clinical development
Zatti S,Martewicz S,Serena E,Uno N,Giobbe G,Kazuki Y,Oshimura M,Elvassore N
MA5-12960 was used in immunocytochemistry and western blot to show that the human artificial chromosome carrying the whole dystrophin genomic sequence is stably maintained throughout the cardiac differentiation process and demonstrate that the dystrophin
Wed May 27 00:00:00 EDT 2015
Combined biophysical and soluble factor modulation induces cardiomyocyte differentiation from human muscle derived stem cells.
Scientific reports
Tchao J,Han L,Lin B,Yang L,Tobita K
MA5-12960 was used in immunohistochemistry to determine how cardiomyocyte differentiation from human muscle derived stem cells due to combined soluble and biophysical factor modulation
Tue Oct 14 00:00:00 EDT 2014
Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes.
PloS one
Ifkovits JL,Addis RC,Epstein JA,Gearhart JD
MA5-12960 was used in immunocytochemistry to analyze the conversion increase of fibroblasts to induced cardiomyocytes through inhibition of TGFbeta signaling
Tue Jan 20 00:00:00 EST 2015
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.
Nature medicine
Maejima Y,Kyoi S,Zhai P,Liu T,Li H,Ivessa A,Sciarretta S,Del Re DP,Zablocki DK,Hsu CP,Lim DS,Isobe M,Sadoshima J
MA5-12960 was used in immunohistochemistry to elucidate the mechanisms by which Mst1 regulates autophagy
Fri Nov 01 00:00:00 EDT 2013
A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.
Nature cell biology
Später D,Abramczuk MK,Buac K,Zangi L,Stachel MW,Clarke J,Sahara M,Ludwig A,Chien KR
MA5-12960 was used in immunocytochemistry and immunohistochemistry to study the utility of HCN4 as a marker of first heart field-derived cells of cardiomyogenic lineage
Sun Sep 01 00:00:00 EDT 2013
Efficient generation of human iPSCs by a synthetic self-replicative RNA.
Cell stem cell
Yoshioka N,Gros E,Li HR,Kumar S,Deacon DC,Maron C,Muotri AR,Chi NC,Fu XD,Yu BD,Dowdy SF
MA5-12960 was used in immunohistochemistry to develop a synthetic self-replicating RNA replicon expressing reprogramming factors that enables the efficient generation of induced pluripotent stem cells
Thu Aug 01 00:00:00 EDT 2013
HCN4 dynamically marks the first heart field and conduction system precursors.
Circulation research
Liang X,Wang G,Lin L,Lowe J,Zhang Q,Bu L,Chen Y,Chen J,Sun Y,Evans SM
MA5-12960 was used in immunohistochemistry to study the value of HCN4 protein expression as a marker of precursors of the first heart field and the cardiac conduction system
Fri Aug 02 00:00:00 EDT 2013
Specification of chondrocytes and cartilage tissues from embryonic stem cells.
Development (Cambridge, England)
Craft AM,Ahmed N,Rockel JS,Baht GS,Alman BA,Kandel RA,Grigoriadis AE,Keller GM
MA5-12960 was used in immunocytochemistry to develop methods for the generation of chondrocytes and cartilage-like tissue from embryonic stem cells
Sat Jun 01 00:00:00 EDT 2013
Hippo signaling impedes adult heart regeneration.
Development (Cambridge, England)
Heallen T,Morikawa Y,Leach J,Tao G,Willerson JT,Johnson RL,Martin JF
MA5-12960 was used in immunohistochemistry to study the repression of adult heart regeneration by Hippo signaling
Sun Dec 01 00:00:00 EST 2013
zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.
Development (Cambridge, England)
Chen CH,Durand E,Wang J,Zon LI,Poss KD
MA5-12960 was used in immunohistochemistry to develop biluminescent zebrafish lines to enable the in vivo imaging of stem cells in adult fish
Sun Dec 01 00:00:00 EST 2013
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.
Journal of molecular and cellular cardiology
Addis RC,Ifkovits JL,Pinto F,Kellam LD,Esteso P,Rentschler S,Christoforou N,Epstein JA,Gearhart JD
MA5-12960 was used in immunocytochemistry to evaluate the method for measuring fibroblast reprogramming to cardiomyocytes
Mon Jul 01 00:00:00 EDT 2013
Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a.
Stem cells and development
Moyes KW,Sip CG,Obenza W,Yang E,Horst C,Welikson RE,Hauschka SD,Folch A,Laflamme MA
MA5-12960 was used in immunocytochemistry to identify the promigatory effects of FN and Wnt5a in human embryonic stem cell-derived cardiomyocytes
Thu Aug 15 00:00:00 EDT 2013
Mouse embryonic stem cells irradiated with γ-rays differentiate into cardiomyocytes but with altered contractile properties.
Mutation research
Rebuzzini P,Fassina L,Mulas F,Bellazzi R,Redi CA,Di Liberto R,Magenes G,Adjaye J,Zuccotti M,Garagna S
MA5-12960 was used in immunohistochemistry to study the effects of gamma-irradiation of murine embryonic stem cells on the gene expression profile and contractile properties following cardiomyocytic differentiation
Fri Aug 30 00:00:00 EDT 2013
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.
Developmental biology
Liu Y,Jin Y,Li J,Seto E,Kuo E,Yu W,Schwartz RJ,Blazo M,Zhang SL,Peng X
MA5-12960 was used in immunohistochemistry to study the role of Cdc42 in craniofacial and cardiovascular morphogenesis
Fri Nov 15 00:00:00 EST 2013
Embryonic stem cells facilitate the isolation of persistent clonal cardiovascular progenitor cell lines and leukemia inhibitor factor maintains their self-renewal and myocardial differentiation potential in vitro.
Cells, tissues, organs
Hoebaus J,Heher P,Gottschamel T,Scheinast M,Auner H,Walder D,Wiedner M,Taubenschmid J,Miksch M,Sauer T,Schultheis M,Kuzmenkin A,Seiser C,Hescheler J,Weitzer G
MA5-12960 was used in immunohistochemistry to develop a protocol for the isolation and long-term maintenance of clonal cardiovascular progenitor cell lines
Mon Sep 23 00:00:00 EDT 2013
Wharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction.
Coronary artery disease
Zhang W,Liu XC,Yang L,Zhu DL,Zhang YD,Chen Y,Zhang HY
MA5-12960 was used in immunohistochemistry to use a miniswine model of acute myocardial infarction to study the therapeutic effects of Wharton's jelly-derived mesenchymal stem cells on cardiac repair and performance
Fri Nov 01 00:00:00 EDT 2013
The ROSA26-iPSC mouse: a conditional, inducible, and exchangeable resource for studying cellular (De)differentiation.
Cell reports
Haenebalcke L,Goossens S,Dierickx P,Bartunkova S,D'Hont J,Haigh K,Hochepied T,Wirth D,Nagy A,Haigh JJ
MA5-12960 was used in immunohistochemistry to develop a ROSA26-iPSC mouse strain as a model for studying cellular differentiation and dedifferentiation
Thu Feb 21 00:00:00 EST 2013
Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells.
PloS one
Lehmann M,Nguemo F,Wagh V,Pfannkuche K,Hescheler J,Reppel M
MA5-12960 was used in immunocytochemistry to study the cardiomyocytic differentiation of murine embryonic stem cells and the key role of catecholamines
Mon Apr 28 00:00:00 EDT 2014
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury.
The Journal of biological chemistry
Del Re DP,Yang Y,Nakano N,Cho J,Zhai P,Yamamoto T,Zhang N,Yabuta N,Nojima H,Pan D,Sadoshima J
MA5-12960 was used in immunohistochemistry to study the role of Yap1 in basal cardiac maintenance and in protecting against myocardial infarction-induced injury
Fri Feb 08 00:00:00 EST 2013
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Nature
Song K,Nam YJ,Luo X,Qi X,Tan W,Huang GN,Acharya A,Smith CL,Tallquist MD,Neilson EG,Hill JA,Bassel-Duby R,Olson EN
MA5-12960 was used in immunocytochemistry and immunohistochemistry to study the ability of the GATA4, HAND2, MEF2C and TBX5 cardiac transcrition factors to reprogram cardiac fibroblasts into functional cardiomyocyte-like cells with cardiac repair potential
Sun May 13 00:00:00 EDT 2012
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.
EMBO molecular medicine
Jung CB,Moretti A,Mederos y Schnitzler M,Iop L,Storch U,Bellin M,Dorn T,Ruppenthal S,Pfeiffer S,Goedel A,Dirschinger RJ,Seyfarth M,Lam JT,Sinnecker D,Gudermann T,Lipp P,Laugwitz KL
MA5-12960 was used in western blot to study an arrhythmia causing RYR2 mutation in cardiomyocytes derived from induced pluripotent stem cells obtained from a catecholaminergic polymorphic ventricular tachycardia patient
Thu Mar 01 00:00:00 EST 2012
Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin.
EMBO reports
van den Ameele J,Tiberi L,Bondue A,Paulissen C,Herpoel A,Iacovino M,Kyba M,Blanpain C,Vanderhaeghen P
MA5-12960 was used in flow cytometry to study the induction of Mesp1 and cardiac differentiation by transient expression of eosodermin in embryonic stem cells
Sun Apr 01 00:00:00 EDT 2012
Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency.
American journal of physiology. Cell physiology
Mastri M,Shah Z,McLaughlin T,Greene CJ,Baum L,Suzuki G,Lee T
MA5-12960 was used in immunohistochemistry to study the effect of TLR-3 activation on mesenchymal stem cell trophic factors and therapeutic potency
Thu Nov 15 00:00:00 EST 2012
Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development.
Developmental biology
Opitz R,Maquet E,Huisken J,Antonica F,Trubiroha A,Pottier G,Janssens V,Costagliola S
MA5-12960 was used in immunohistochemistry to study the dynamics of thyroid development and its relationship to the development of the cardiovascular system using a novel transgenic zebrafish model
Sat Dec 15 00:00:00 EST 2012
Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells.
Stem cell reviews and reports
Pieters T,Haenebalcke L,Hochepied T,D'Hont J,Haigh JJ,van Roy F,van Hengel J
MA5-12960 was used in immunocytochemistry to develop an efficient method for the derivation of murine embryonic stem cells using pluripotin
Sat Sep 01 00:00:00 EDT 2012
Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells.
International journal of cell biology
Hazeltine LB,Simmons CS,Salick MR,Lian X,Badur MG,Han W,Delgado SM,Wakatsuki T,Crone WC,Pruitt BL,Palecek SP
MA5-12960 was used in flow cytometry to study the effects of substrate mechanics on contractility of cardiomyocytes derived from human pluripotent stem cells
Thu Aug 23 00:00:00 EDT 2012
ILK induces cardiomyogenesis in the human heart.
PloS one
Traister A,Aafaqi S,Masse S,Dai X,Li M,Hinek A,Nanthakumar K,Hannigan G,Coles JG
MA5-12960 was used in immunohistochemistry to study the role of integrin-linked kinase in cardiomyogenesis
Mon Oct 29 00:00:00 EDT 2012
Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.
The Journal of biological chemistry
Wei WJ,Sun HY,Ting KY,Zhang LH,Lee HC,Li GR,Yue J
MA5-12960 was used in flow cytometry and immunohistochemistry to investigate the role of CD38-cADPR-Ca(2+) in the cardiomyogenesis of mouse embryonic stem cells
Fri Oct 12 00:00:00 EDT 2012
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.
Nature biotechnology
Dubois NC,Craft AM,Sharma P,Elliott DA,Stanley EG,Elefanty AG,Gramolini A,Keller G
MA5-12960 was used in flow cytometry to study SIRPA as a specifc cell surface marker for isolating cardiomyocytes derived from human pluripotent stem cells
Sun Oct 23 00:00:00 EDT 2011
Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway.
Acta pharmacologica Sinica
Lee YK,Ng KM,Lai WH,Man C,Lieu DK,Lau CP,Tse HF,Siu CW
MA5-12960 was used in immunocytochemistry to investigate the effect of ouabain on cardiac differentiation
Sat Jan 01 00:00:00 EST 2011
Cardiac origin of smooth muscle cells in the inflow tract.
Journal of molecular and cellular cardiology
Nakano H,Williams E,Hoshijima M,Sasaki M,Minamisawa S,Chien KR,Nakano A
MA5-12960 was used in immunohistochemistry to study the developmental origin of cardiac and smooth muscle cells in the cardiac inflow tract
Tue Feb 01 00:00:00 EST 2011
The differentiation of cardiomyocytes from mouse embryonic stem cells is altered by dioxin.
Toxicology letters
Neri T,Merico V,Fiordaliso F,Salio M,Rebuzzini P,Sacchi L,Bellazzi R,Redi CA,Zuccotti M,Garagna S
MA5-12960 was used in immunocytochemistry to study the effects of dioxin on the differentiation of mouse embryonic stem cells into cardiomyocytes
Tue May 10 00:00:00 EDT 2011
Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level.
Cellular reprogramming
Ng KM,Chan YC,Lee YK,Lai WH,Au KW,Fung ML,Siu CW,Li RA,Tse HF
MA5-12960 was used in immunohistochemistry to investigate cardiac differentiation of human embryonic stem cells induced by cobalt chloride
Thu Dec 01 00:00:00 EST 2011
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression.
PloS one
Uosaki H,Fukushima H,Takeuchi A,Matsuoka S,Nakatsuji N,Yamanaka S,Yamashita JK
MA5-12960 was used in flow cytometry to characterize cell surface markers for human cardiomyocytes derived from human embryonic and induced pluripotent stem cells
Fri Dec 30 00:00:00 EST 2011
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.
Toxicological sciences : an official journal of the Society of Toxicology
Guo L,Abrams RM,Babiarz JE,Cohen JD,Kameoka S,Sanders MJ,Chiao E,Kolaja KL
MA5-12960 was used in immunocytochemistry to develop a new method for evaluating drug-induced proarrhythmic risk
Thu Sep 01 00:00:00 EDT 2011
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.
Cell stem cell
Kattman SJ,Witty AD,Gagliardi M,Dubois NC,Niapour M,Hotta A,Ellis J,Keller G
MA5-12960 was used in flow cytometry to study the role of activin/nodal and BMP signaling in promoting cardiac differentiation of pluripotent stem cell lines
Fri Feb 04 00:00:00 EST 2011
Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
PloS one
Kim EY,Chen L,Ma Y,Yu W,Chang J,Moskowitz IP,Wang J
MA5-12960 was used in immunohistochemistry to study the role of sumoylation in regulating the function of the cardiac specific homeobox gene Nkx2.5
Mon Oct 17 00:00:00 EDT 2011
Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.
Cytotherapy
Gaur M,Ritner C,Sievers R,Pedersen A,Prasad M,Bernstein HS,Yeghiazarians Y
MA5-12960 was used in immunocytochemistry to investigate the differentiation human embryonic stem cells into cardiomyocytes
Fri Oct 01 00:00:00 EDT 2010
Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Moretti A,Bellin M,Jung CB,Thies TM,Takashima Y,Bernshausen A,Schiemann M,Fischer S,Moosmang S,Smith AG,Lam JT,Laugwitz KL
MA5-12960 was used in immunohistochemistry to study mouse and human induced pluripotent stem cells as a source of multipotent Isl1+ cardiovascular progenitors
Mon Mar 01 00:00:00 EST 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
MA5-12960 was used in immunocytochemistry to study role of mesenchymal cells in cardiac differential and calcium homeostasis
Thu Apr 01 00:00:00 EDT 2010
Icariin-mediated differentiation of mouse adipose-derived stem cells into cardiomyocytes.
Molecular and cellular biochemistry
Jin MS,Shi S,Zhang Y,Yan Y,Sun XD,Liu W,Liu HW
MA5-12960 was used in immunocytochemistry to investigate the differentiation of mouse fat-derived stem cells into heart cells
Mon Nov 01 00:00:00 EDT 2010
Isolation and functional characterization of alpha-smooth muscle actin expressing cardiomyocytes from embryonic stem cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Potta SP,Liang H,Winkler J,Doss MX,Chen S,Wagh V,Pfannkuche K,Hescheler J,Sachinidis A
MA5-12960 was used in immunocytochemistry to isolate and characterize Acta2-positive cardiomyocytes
Wed Sep 22 00:00:00 EDT 2010
Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar.
BMC developmental biology
Gupta MK,Illich DJ,Gaarz A,Matzkies M,Nguemo F,Pfannkuche K,Liang H,Classen S,Reppel M,Schultze JL,Hescheler J,Sarić T
MA5-12960 was used in immunocytochemistry to study the global transcriptomes of beating clusters isolated from human induced pluripotent stem cells cells and embryonic stem cells
Wed Sep 15 00:00:00 EDT 2010
Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway.
Molecular endocrinology (Baltimore, Md.)
Lee YK,Ng KM,Chan YC,Lai WH,Au KW,Ho CY,Wong LY,Lau CP,Tse HF,Siu CW
MA5-12960 was used in immunocytochemistry to investigate the effect of triiodothyronine on cardiac differentiation and maturation of embryonic stem cells
Wed Sep 01 00:00:00 EDT 2010
Effects of iron oxide nanoparticles on cardiac differentiation of embryonic stem cells.
Biochemical and biophysical research communications
Au KW,Liao SY,Lee YK,Lai WH,Ng KM,Chan YC,Yip MC,Ho CY,Wu EX,Li RA,Siu CW,Tse HF
MA5-12960 was used in immunohistochemistry to evaluate superparamagnetic iron oxide nanoparticle labeling of embryonic stem cells during myocardial transplant and differentiation
Fri Feb 20 00:00:00 EST 2009
A myocardial lineage derives from Tbx18 epicardial cells.
Nature
Cai CL,Martin JC,Sun Y,Cui L,Wang L,Ouyang K,Yang L,Bu L,Liang X,Zhang X,Stallcup WB,Denton CP,McCulloch A,Chen J,Evans SM
MA5-12960 was used in immunohistochemistry to study a myocardial lineage derived from Tbx18 epicardial cells
Thu Jul 03 00:00:00 EDT 2008
Generation of functional murine cardiac myocytes from induced pluripotent stem cells.
Circulation
Mauritz C,Schwanke K,Reppel M,Neef S,Katsirntaki K,Maier LS,Nguemo F,Menke S,Haustein M,Hescheler J,Hasenfuss G,Martin U
MA5-12960 was used in immunocytochemistry to examine the myocardic differentiation of induced pluripotent murine stem cells
Tue Jul 29 00:00:00 EDT 2008
A high-efficiency system for the generation and study of human induced pluripotent stem cells.
Cell stem cell
Maherali N,Ahfeldt T,Rigamonti A,Utikal J,Cowan C,Hochedlinger K
MA5-12960 was used in immunohistochemistry to develop a high-efficiency lentiviral system for the generation and study of human induced pluripotent stem cells
Thu Sep 11 00:00:00 EDT 2008
Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban).
Critical care medicine
van der Hoorn JW,Jukema JW,Bekkers ME,Princen HM,Corda S,Emeis JJ,Steendijk P
MA5-12960 was used in immunohistochemistry to study the ability of a thromboxane prostanoid receptor antagonist to protect against the negative cardiac effects of a selective Cox-2 inhibitor
Mon Sep 01 00:00:00 EDT 2008
Electrostimulation induces cardiomyocyte predifferentiation of fibroblasts.
Biochemical and biophysical research communications
Genovese JA,Spadaccio C,Langer J,Habe J,Jackson J,Patel AN
MA5-12960 was used in western blot to investigate the effect of electrostimulation on fibroblast pre-commitment into cardiomyocytes
Fri Jun 06 00:00:00 EDT 2008
Gremlin enhances the determined path to cardiomyogenesis.
PloS one
Kami D,Shiojima I,Makino H,Matsumoto K,Takahashi Y,Ishii R,Naito AT,Toyoda M,Saito H,Watanabe M,Komuro I,Umezawa A
MA5-12960 was used in immunocytochemistry to examine the role of gremlin in cardiomyogenesis
Wed Jun 11 00:00:00 EDT 2008
Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.
Cell stem cell
Bondue A,Lapouge G,Paulissen C,Semeraro C,Iacovino M,Kyba M,Blanpain C
MA5-12960 was used in flow cytometry and immunocytochemistry to study the role of Mesp1 as a master regulator of multipotent cardiovascular progenitor specification
Thu Jul 03 00:00:00 EDT 2008
Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma.
PloS one
Yamanaka S,Zahanich I,Wersto RP,Boheler KR
MA5-12960 was used in immunocytochemistry to develop an in vitro model of cardiac cell cycle progression in vitro using monolayer cultures of highly proliferative embryonic stem cell-derived cardiomyocytes
Wed Apr 08 00:00:00 EDT 2009
New cell lines from mouse epiblast share defining features with human embryonic stem cells.
Nature
Tesar PJ,Chenoweth JG,Brook FA,Davies TJ,Evans EP,Mack DL,Gardner RL,McKay RD
MA5-12960 was used in immunocytochemistry to examine the totipotency of mouse epiblast
Thu Jul 12 00:00:00 EDT 2007
Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration.
Journal of cell science
Tateishi K,Ashihara E,Takehara N,Nomura T,Honsho S,Nakagami T,Morikawa S,Takahashi T,Ueyama T,Matsubara H,Oh H
MA5-12960 was used in immunohistochemistry to study the role of Sca-1 signaling in regulating efficient cardiovascular regeneration by clonally amplified cardiac stem cells
Tue May 15 00:00:00 EDT 2007
Coexpression of platelet-derived growth factor receptor alpha and fetal liver kinase 1 enhances cardiogenic potential in embryonic stem cell differentiation in vitro.
Journal of bioscience and bioengineering
Hirata H,Kawamata S,Murakami Y,Inoue K,Nagahashi A,Tosaka M,Yoshimura N,Miyamoto Y,Iwasaki H,Asahara T,Sawa Y
MA5-12960 was used in immunocytochemistry to examine the cardiogenic differentiation of embryonic stem cells in vitro
Tue May 01 00:00:00 EDT 2007
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis.
The Journal of experimental medicine
Kuhlmann MT,Kirchhof P,Klocke R,Hasib L,Stypmann J,Fabritz L,Stelljes M,Tian W,Zwiener M,Mueller M,Kienast J,Breithardt G,Nikol S
MA5-12960 was used in immunohistochemistry to investigate the electrophysiological effects of granulocyte colony-stimulating factor/stem cell factor on infarcted hearts
Mon Jan 23 00:00:00 EST 2006
ALCAM (CD166) is a surface marker for early murine cardiomyocytes.
Cells, tissues, organs
Hirata H,Murakami Y,Miyamoto Y,Tosaka M,Inoue K,Nagahashi A,Jakt LM,Asahara T,Iwata H,Sawa Y,Kawamata S
MA5-12960 was used in immunohistochemistry to evaluate ALCAM as a surface marker for early murine cardiomyocytes
Fri May 25 00:00:00 EDT 2007
Combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells in canine hearts for ischemic cardiomyopathy.
The Journal of thoracic and cardiovascular surgery
Memon IA,Sawa Y,Miyagawa S,Taketani S,Matsuda H
MA5-12960 was used in immunohistochemistry to study the therapeutic effects of treating canine ischemic cardiomyopathy with autologous cardioplasty using skeletal myoblasts plus bone marrow cells
Thu Sep 01 00:00:00 EDT 2005
Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential.
Biochemical and biophysical research communications
Lauss M,Stary M,Tischler J,Egger G,Puz S,Bader-Allmer A,Seiser C,Weitzer G
MA5-12960 was used in immunocytochemistry to investigate the characteristics of embryonic stem cells derived from inner cell mass
Fri Jun 17 00:00:00 EDT 2005
Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage.
The Journal of cell biology
Gerhart J,Neely C,Stewart B,Perlman J,Beckmann D,Wallon M,Knudsen K,George-Weinstein M
MA5-12960 was used in immunocytochemistry to show that MyoD-positive epiblast cells recruit pluripotent cells to the skeletal muscle lineage
Mon Mar 01 00:00:00 EST 2004
Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells.
Biochemical and biophysical research communications
Shim WS,Jiang S,Wong P,Tan J,Chua YL,Tan YS,Sin YK,Lim CH,Chua T,Teh M,Liu TC,Sim E
MA5-12960 was used in immunocytochemistry to study the ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells
Fri Nov 12 00:00:00 EST 2004
The MRL mouse heart healing response shows donor dominance in allogeneic fetal liver chimeric mice.
Cloning and stem cells
Bedelbaeva K,Gourevitch D,Clark L,Chen P,Leferovich JM,Heber-Katz E
MA5-12960 was used in immunohistochemistry to study the role of fetal liver-derived stem cells in regenerative healing in mouse heart
Fri Apr 22 00:00:00 EDT 2005
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.jpg?time=20220826?time=20220826 "Cardiac Troponin T Antibody (MA5-12960) in ICC/IF")
.jpg?time=20220826?time=20220826 "Cardiac Troponin T Antibody (MA5-12960) in ICC/IF")
.jpg?time=20220826?time=20220826 "Cardiac Troponin T Antibody (MA5-12960) in IHC (P)")
